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1.发明申请公开(公告)号：US20060189941A1
公开(公告)日：2006-08-24
申请号：US11365309
申请日：2006-02-28
申请人： Kirk Seward , Lynn Barr , Judith Wilber , Robert Cafferata
发明人： Kirk Seward , Lynn Barr , Judith Wilber , Robert Cafferata
IPC分类号： A61M5/178
CPC分类号： A61M25/10 , A61M25/0084 , A61M2025/0096 , A61M2025/1086
摘要： Methods and kits for delivering pharmaceutical agents to the adventitia and other regions outside the external elastic lamina (EEL) surrounding a blood vessel utilize a catheter having a needle. The needle is positioned in up to 5 mm beyond the EEL and delivers an amount of pharmaceutical agent sufficient to circumferentially permeate around the blood vessel and, in many cases, extend longitudinally and radially along the blood vessel. Confirmation that a delivery aperture of the needle lies beyond the EEL may be required before delivering the pharmaceutical agent.
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2.发明申请公开(公告)号：US20070106257A1
公开(公告)日：2007-05-10
申请号：US11607356
申请日：2006-12-01
申请人： Kirk Seward , Lynn Barr , Judith Wilber , Robert Cafferata
发明人： Kirk Seward , Lynn Barr , Judith Wilber , Robert Cafferata
IPC分类号： A61M31/00
CPC分类号： A61L29/16 , A61L31/16 , A61L2300/416 , A61L2300/422 , A61M25/0084 , A61M25/10 , A61M37/00 , A61M37/0015 , A61M2025/0093 , A61M2025/0096 , A61M2025/1086
摘要： Methods and kits for delivering pharmaceutical agents to the adventitia surrounding a blood vessel utilize a catheter having a microneedle. The microneedle is positioned in the perivascular space and delivers an amount of pharmaceutical agent sufficient to circumferentially permeate around the blood vessel and, in many cases, extend longitudinally along the blood vessel and in some cases to the adventitia surrounding other blood vessels.
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3.发明申请公开(公告)号：US20070106255A1
公开(公告)日：2007-05-10
申请号：US11607178
申请日：2006-12-01
申请人： Kirk Seward , Lynn Barr , Judith Wilber , Robert Cafferata
发明人： Kirk Seward , Lynn Barr , Judith Wilber , Robert Cafferata
IPC分类号： A61M31/00
CPC分类号： A61L29/16 , A61L31/16 , A61L2300/416 , A61L2300/422 , A61M25/0084 , A61M25/10 , A61M37/00 , A61M37/0015 , A61M2025/0093 , A61M2025/0096 , A61M2025/1086
摘要： Methods and kits for delivering pharmaceutical agents to the adventitia surrounding a blood vessel utilize a catheter having a microneedle. The microneedle is positioned in the perivascular space and delivers an amount of pharmaceutical agent sufficient to circumferentially permeate around the blood vessel and, in many cases, extend longitudinally along the blood vessel and in some cases to the adventitia surrounding other blood vessels.
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4.发明申请公开(公告)号：US20070106249A1
公开(公告)日：2007-05-10
申请号：US11607168
申请日：2006-12-01
申请人： Kirk Seward , Lynn Barr , Judith Wilber , Robert Cafferata
发明人： Kirk Seward , Lynn Barr , Judith Wilber , Robert Cafferata
IPC分类号： A61M31/00
CPC分类号： A61L29/16 , A61L31/16 , A61L2300/416 , A61L2300/422 , A61M25/0084 , A61M25/10 , A61M37/00 , A61M37/0015 , A61M2025/0093 , A61M2025/0096 , A61M2025/1086
摘要： Methods and kits for delivering pharmaceutical agents to the adventitia surrounding a blood vessel utilize a catheter having a microneedle. The microneedle is positioned in the perivascular space and delivers an amount of pharmaceutical agent sufficient to circumferentially permeate around the blood vessel and, in many cases, extend longitudinally along the blood vessel and in some cases to the adventitia surrounding other blood vessels.
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5.发明申请公开(公告)号：US20070106254A1
公开(公告)日：2007-05-10
申请号：US11607177
申请日：2006-12-01
申请人： Kirk Seward , Lynn Barr , Judith Wilber , Robert Cafferata
发明人： Kirk Seward , Lynn Barr , Judith Wilber , Robert Cafferata
IPC分类号： A61M31/00
CPC分类号： A61L29/16 , A61L31/16 , A61L2300/416 , A61L2300/422 , A61M25/0084 , A61M25/10 , A61M37/00 , A61M37/0015 , A61M2025/0093 , A61M2025/0096 , A61M2025/1086
摘要： Methods and kits for delivering pharmaceutical agents to the adventitia surrounding a blood vessel utilize a catheter having a microneedle. The microneedle is positioned in the perivascular space and delivers an amount of pharmaceutical agent sufficient to circumferentially permeate around the blood vessel and, in many cases, extend longitudinally along the blood vessel and in some cases to the adventitia surrounding other blood vessels.
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6.发明申请公开(公告)号：US20070106253A1
公开(公告)日：2007-05-10
申请号：US11607176
申请日：2006-12-01
申请人： Kirk Seward , Lynn Barr , Judith Wilber , Robert Cafferata
发明人： Kirk Seward , Lynn Barr , Judith Wilber , Robert Cafferata
IPC分类号： A61M31/00
CPC分类号： A61L29/16 , A61L31/16 , A61L2300/416 , A61L2300/422 , A61M25/0084 , A61M25/10 , A61M37/00 , A61M37/0015 , A61M2025/0093 , A61M2025/0096 , A61M2025/1086
摘要： Methods and kits for delivering pharmaceutical agents to the adventitia surrounding a blood vessel utilize a catheter having a microneedle. The microneedle is positioned in the perivascular space and delivers an amount of pharmaceutical agent sufficient to circumferentially permeate around the blood vessel and, in many cases, extend longitudinally along the blood vessel and in some cases to the adventitia surrounding other blood vessels.
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7.发明申请公开(公告)号：US20070106252A1
公开(公告)日：2007-05-10
申请号：US11607175
申请日：2006-12-01
申请人： Kirk Seward , Lynn Barr , Judith Wilber , Robert Cafferata
发明人： Kirk Seward , Lynn Barr , Judith Wilber , Robert Cafferata
IPC分类号： A61M31/00
CPC分类号： A61L29/16 , A61L31/16 , A61L2300/416 , A61L2300/422 , A61M25/0084 , A61M25/10 , A61M37/00 , A61M37/0015 , A61M2025/0093 , A61M2025/0096 , A61M2025/1086
摘要： Methods and kits for delivering pharmaceutical agents to the adventitia surrounding a blood vessel utilize a catheter having a microneedle. The microneedle is positioned in the perivascular space and delivers an amount of pharmaceutical agent sufficient to circumferentially permeate around the blood vessel and, in many cases, extend longitudinally along the blood vessel and in some cases to the adventitia surrounding other blood vessels.
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8.发明申请公开(公告)号：US20070106248A1
公开(公告)日：2007-05-10
申请号：US11607166
申请日：2006-12-01
申请人： Kirk Seward , Lynn Barr , Judith Wilber , Robert Cafferata
发明人： Kirk Seward , Lynn Barr , Judith Wilber , Robert Cafferata
IPC分类号： A61M31/00
CPC分类号： A61L29/16 , A61L31/16 , A61L2300/416 , A61L2300/422 , A61M25/0084 , A61M25/10 , A61M37/00 , A61M37/0015 , A61M2025/0093 , A61M2025/0096 , A61M2025/1086
摘要： Methods and kits for delivering pharmaceutical agents to the adventitia surrounding a blood vessel utilize a catheter having a microneedle. The microneedle is positioned in the perivascular space and delivers an amount of pharmaceutical agent sufficient to circumferentially permeate around the blood vessel and, in many cases, extend longitudinally along the blood vessel and in some cases to the adventitia surrounding other blood vessels.
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9.发明申请公开(公告)号：US20070078620A1
公开(公告)日：2007-04-05
申请号：US11607658
申请日：2006-12-01
申请人： Kirk Seward , Lynn Barr , Judith Wilber , Robert Cafferata
发明人： Kirk Seward , Lynn Barr , Judith Wilber , Robert Cafferata
IPC分类号： G06F15/00
CPC分类号： A61M25/10 , A61B17/3478 , A61M25/0084 , A61M37/0015 , A61M2025/1086
摘要： Methods and kits for delivering pharmaceutical agents to the adventitia surrounding a blood vessel utilize a catheter having a microneedle. The microneedle is positioned in the perivascular space and delivers an amount of pharmaceutical agent sufficient to circumferentially permeate around the blood vessel and, in many cases, extend longitudinally along the blood vessel and in some cases to the adventitia surrounding other blood vessels.
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10.发明申请公开(公告)号：US20070106256A1
公开(公告)日：2007-05-10
申请号：US11607355
申请日：2006-12-01
申请人： Kirk Seward , Lynn Barr , Judith Wilber , Robert Cafferata
发明人： Kirk Seward , Lynn Barr , Judith Wilber , Robert Cafferata
IPC分类号： A61M31/00
CPC分类号： A61L29/16 , A61L31/16 , A61L2300/416 , A61L2300/422 , A61M25/0084 , A61M25/10 , A61M37/00 , A61M37/0015 , A61M2025/0093 , A61M2025/0096 , A61M2025/1086
摘要： Methods and kits for delivering pharmaceutical agents to the adventitia surrounding a blood vessel utilize a catheter having a microneedle. The microneedle is positioned in the perivascular space and delivers an amount of pharmaceutical agent sufficient to circumferentially permeate around the blood vessel and, in many cases, extend longitudinally along the blood vessel and in some cases to the adventitia surrounding other blood vessels.
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