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    Method of judging leukemia, pre-leukemia or aleukemic malignant blood disease and diagnostic therefor
    1.
    发明授权
    Method of judging leukemia, pre-leukemia or aleukemic malignant blood disease and diagnostic therefor 失效
    判断白血病，白血病前或白血病恶性血液病的诊断方法

    公开(公告)号：US07479371B2

    公开(公告)日：2009-01-20

    申请号：US10510627

    申请日：2003-04-09

    申请人： Kiyoshi Ando ,  Tomomitsu Hotta ,  Chie Ito ,  Hidenao Sato ,  Akiko Furuya ,  Kenya Shitara ,  Seiji Sugimoto ,  Hiroaki Kohno

    发明人： Kiyoshi Ando ,  Tomomitsu Hotta ,  Chie Ito ,  Hidenao Sato ,  Akiko Furuya ,  Kenya Shitara ,  Seiji Sugimoto ,  Hiroaki Kohno

    IPC分类号： G01N33/53 ,  C07K16/00

    CPC分类号： C07K16/22 ,  G01N33/57426 ,  G01N2333/475

    摘要： The present invention relates to a method for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases, a method of discriminating leukemia from pre-leukemia or aleukemic malignant blood diseases, a method of discriminating aplastic anemia from myelodysplastic syndrome, a method of diagnosing delayed engraftment of the hematopoietic stem cells after transplantation of the hematopoietic stem cells, and a method of diagnosing the graft versus host disease, each of said methods comprising quantifying stem cell growth factor (SCGF). The present invention also makes it possible to provide an agent for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases and an agent for diagnosing delayed engraftment of the hematopoietic stem cells after transplantation of the hematopoietic stem cells or an agent for diagnosing graft versus host disease (GVHD), each containing as an active ingredient an antibody reacting with stem cell growth factor (SCGF).

    摘要翻译： 本发明涉及白血病，白血病前或白血病恶性血液病诊断方法，白血病与白血病前白血病恶性血液疾病的鉴别方法，再生障碍性贫血与骨髓增生异常综合征的鉴别方法，延迟诊断方法 造血干细胞移植后造血干细胞的移植，以及诊断移植物抗宿主病的方法，每种方法包括量化干细胞生长因子（SCGF）。 本发明还可以提供用于诊断白血病，白血病前或白血病恶性血液病的药剂和用于诊断造血干细胞移植后的造血干细胞的延迟植入或用于诊断移植物与宿主的试剂的试剂 疾病（GVHD），各自含有与干细胞生长因子（SCGF）反应的抗体作为活性成分。

    Antidepressants or foods and beverage for antidepression
    3.
    发明申请
    Antidepressants or foods and beverage for antidepression 审中-公开
    抗抑郁药或抗抑郁食品和饮料

    公开(公告)号：US20070021355A1

    公开(公告)日：2007-01-25

    申请号：US10558706

    申请日：2004-05-28

    申请人： Hiroaki Kohno ,  Hideaki Kusaka

    发明人： Hiroaki Kohno ,  Hideaki Kusaka

    IPC分类号： A61K31/7056

    CPC分类号： C07D405/04 ,  A23L2/52 ,  A23L33/10 ,  A61K31/404 ,  A61K31/7056 ,  C07H7/06

    摘要： An object of the present invention is to provide antidepressants or foods and drinks for antidepression. To solve the present problem, the present invention provides antidepressants or foods and drinks for antidepression comprising, as an active ingredient, a compound represented by formula (I): (wherein R1, R2, R3 and R4, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, or the like; R5 represents a hydrogen atom, hydroxy, or the like; R6 represents a hydrogen atom, or the like; R7 represents a hydrogen atom or substituted or unsubstituted lower alkyl; and R8, R9, R10 and R11, which may be the same or different, each represent a hydrogen atom or substituted or unsubstituted lower alkyl) or a salt thereof.

    摘要翻译： 本发明的目的是提供抗抑郁药或食品和饮料用于抗抑郁。 为了解决本发明的问题，本发明提供了抗抑郁药或抗抑郁药的食品和饮料，其含有作为活性成分的式（I）表示的化合物：（其中R 1，R 2，R 2， R 3，R 3和R 4可以相同或不同，各自表示氢原子，取代或未取代的低级烷基等; R 5是氢原子，羟基等; R 6表示氢原子等; R 7表示氢原子， 或取代或未取代的低级烷基;和R 8，R 9，R 10和R 11，其可以 相同或不同，各自表示氢原子或取代或未取代的低级烷基）或其盐。

    Compound 2-amino-3-[2-(&agr;-mannopyranosyl)indol-3-yl]propionic acid, process for preparing the same, and method for inspecting function of living body with the novel compound
    4.
    发明授权
    Compound 2-amino-3-[2-(&agr;-mannopyranosyl)indol-3-yl]propionic acid, process for preparing the same, and method for inspecting function of living body with the novel compound 有权
    化合物2-氨基-3- [2-（α-甘露吡喃糖基）吲哚-3-基]丙酸，其制备方法以及用新化合物检测活体功能的方法

    公开(公告)号：US06610502B1

    公开(公告)日：2003-08-26

    申请号：US09486115

    申请日：2000-02-18

    申请人： Hiroaki Kohno ,  Osamu Yonekawa ,  Yutaka Fujise ,  Kentaro Horiuchi ,  Kyoko Adachi ,  Hiroshi Sano

    发明人： Hiroaki Kohno ,  Osamu Yonekawa ,  Yutaka Fujise ,  Kentaro Horiuchi ,  Kyoko Adachi ,  Hiroshi Sano

    IPC分类号： G01N33577

    CPC分类号： C07H19/044 ,  C07K16/44 ,  G01N33/50 ,  G01N33/5308

    摘要： The present invention relates to a novel endogenous compound 2-amino-3-[2-(&agr;-mannopyranosyl)indole-3-yl]propionic acid; to a method for testing a biological function by quantitating 2-amino-3-[2-(&agr;-mannopyranosyl)indole-3-yl]propionic acid in a collected biological sample and determining the biological function based on the quantitated values; to an antibody specifically reactive with 2-amino-3-[2-(&agr;-mannopyranosyl)indole-3-yl]propionic acid; to a hybridoma that produces the antibody; to a method for immunologically quantitating 2-amino-3-[2-(&agr;-mannopyranosyl)indole-3-yl]propionic acid in a sample by using the antibody; and to a process for producing a 2-amino-3-[2-(&agr;-mannopyranosyl)indole-3-yl]propionic acid derivative.

    摘要翻译： 本发明涉及新的内源化合物2-氨基-3- [2-（α-甘桂吡喃糖基）吲哚-3-基]丙酸; 涉及通过在收集的生物样品中定量2-氨基-3- [2-（α-甘露吡喃糖基）吲哚-3-基]丙酸来测定生物学功能的方法，并基于定量值确定生物学功能; 与2-氨基-3- [2-（α-甘露吡喃糖基）吲哚-3-基]丙酸特异性反应的抗体; 产生抗体的杂交瘤; 涉及通过使用抗体免疫定量样品中2-氨基-3- [2-（α-甘露吡喃糖基）吲哚-3-基]丙酸的方法; 以及2-氨基-3- [2-（α-甘露吡喃糖基）吲哚-3-基]丙酸衍生物的制备方法。