公开(公告)号：US20060084122A1

公开(公告)日：2006-04-20

申请号：US10510627

申请日：2003-04-09

申请人： Kiyoshi Ando ,  Tomomitsu Hotta ,  Chie Ito ,  Hidenao Sato ,  Akiko Furuya ,  Kenya Shatara ,  Seiji Sugimoto ,  Hiroaki Kohno

发明人： Kiyoshi Ando ,  Tomomitsu Hotta ,  Chie Ito ,  Hidenao Sato ,  Akiko Furuya ,  Kenya Shatara ,  Seiji Sugimoto ,  Hiroaki Kohno

IPC分类号： G01N33/574

CPC分类号： C07K16/22 ,  G01N33/57426 ,  G01N2333/475

摘要： The present invention relates to a method for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases, a method of discriminating leukemia from pre-leukemia or aleukemic malignant blood diseases, a method of discriminating aplastic anemia from myelodysplastic syndrome, a method of diagnosing delayed engraftment of the hematopoietic stem cells after transplantation of the hematopoietic stem cells, and a method of diagnosing the graft versus host disease, each of said methods comprising quantifying stem cell growth factor (SCGF). The present invention also makes it possible to provide an agent for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases and an agent for diagnosing delayed engraftment of the hematopoietic stem cells after transplantation of the hematopoietic stem cells or an agent for diagnosing graft versus host disease (GVHD), each containing as an active ingredient an antibody reacting with stem cell growth factor (SCGF).

公开(公告)号：US07479371B2

公开(公告)日：2009-01-20

申请号：US10510627

申请日：2003-04-09

申请人： Kiyoshi Ando ,  Tomomitsu Hotta ,  Chie Ito ,  Hidenao Sato ,  Akiko Furuya ,  Kenya Shitara ,  Seiji Sugimoto ,  Hiroaki Kohno

发明人： Kiyoshi Ando ,  Tomomitsu Hotta ,  Chie Ito ,  Hidenao Sato ,  Akiko Furuya ,  Kenya Shitara ,  Seiji Sugimoto ,  Hiroaki Kohno

IPC分类号： G01N33/53 ,  C07K16/00

CPC分类号： C07K16/22 ,  G01N33/57426 ,  G01N2333/475

摘要： The present invention relates to a method for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases, a method of discriminating leukemia from pre-leukemia or aleukemic malignant blood diseases, a method of discriminating aplastic anemia from myelodysplastic syndrome, a method of diagnosing delayed engraftment of the hematopoietic stem cells after transplantation of the hematopoietic stem cells, and a method of diagnosing the graft versus host disease, each of said methods comprising quantifying stem cell growth factor (SCGF). The present invention also makes it possible to provide an agent for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases and an agent for diagnosing delayed engraftment of the hematopoietic stem cells after transplantation of the hematopoietic stem cells or an agent for diagnosing graft versus host disease (GVHD), each containing as an active ingredient an antibody reacting with stem cell growth factor (SCGF).

摘要翻译： 本发明涉及白血病，白血病前或白血病恶性血液病诊断方法，白血病与白血病前白血病恶性血液疾病的鉴别方法，再生障碍性贫血与骨髓增生异常综合征的鉴别方法，延迟诊断方法 造血干细胞移植后造血干细胞的移植，以及诊断移植物抗宿主病的方法，每种方法包括量化干细胞生长因子（SCGF）。 本发明还可以提供用于诊断白血病，白血病前或白血病恶性血液病的药剂和用于诊断造血干细胞移植后的造血干细胞的延迟植入或用于诊断移植物与宿主的试剂的试剂 疾病（GVHD），各自含有与干细胞生长因子（SCGF）反应的抗体作为活性成分。

公开(公告)号：US20070067854A1

公开(公告)日：2007-03-22

申请号：US11602446

申请日：2006-11-20

申请人： Sonoko Habu ,  Kiyoshi Ando ,  Tomomitsu Hotta

发明人： Sonoko Habu ,  Kiyoshi Ando ,  Tomomitsu Hotta

IPC分类号： A01K67/027 ,  C12P21/08

CPC分类号： C12N15/8509 ,  A01K67/0271 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/01 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/2878 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/74

摘要： Chimeric mice were constructed by transferring human CD34+ cells (hematopoietic stem cells) into a SCID mouse. In these chimeric mice, hematopoietic stem cells persistently differentiated into immune cells. Consequently, the chimeric mice can be immunized over a long time and enable one to obtain human antibodies against arbitrary antigens containing a human self-component.

摘要翻译： 通过将人CD34 +细胞（造血干细胞）转移到SCID小鼠中构建嵌合小鼠。 在这些嵌合小鼠中，造血干细胞持续分化成免疫细胞。 因此，可以长时间免疫嵌合小鼠，能够获得针对含有人自身成分的任意抗原的人抗体。

公开(公告)号：US20050079606A1

公开(公告)日：2005-04-14

申请号：US10490143

申请日：2002-09-20

申请人： Tetsuro Tamaki ,  Akira Akatsuka ,  Kiyoshi Ando ,  Yoshihiko Nakamura ,  Tomomitsu Hotta ,  Kazuhiro Sakurada

发明人： Tetsuro Tamaki ,  Akira Akatsuka ,  Kiyoshi Ando ,  Yoshihiko Nakamura ,  Tomomitsu Hotta ,  Kazuhiro Sakurada

IPC分类号： A61K35/12 ,  C12N5/077 ,  G01N33/50 ,  C12N5/08

CPC分类号： G01N33/5073 ,  A61K35/12 ,  C12N5/0668 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2503/02 ,  C12N2510/04 ,  G01N33/5008 ,  G01N33/5061

摘要： The present invention relates to multipotent stem cells derived from the interstitial tissues of skeletal muscle. The multipotent stem cell of the present invention is capable of differentiating into skeletal muscle cells, smooth muscle cells, cardiomyocytes, blood cells, vascular endothelial cells, adipocytes, osteoblasts, nervous cells, hepatocytes and pancreatic cells, and is useful for regeneration of tissues and cells and treatment for cardiac failure, hepatic insufficiency, renal insufficiency, leukemia, nerve degeneration disease, arthritis, diabetes, arteriosclerosis, and the like.

摘要翻译： 本发明涉及衍生自骨骼肌间质组织的多能干细胞。 本发明的多能干细胞能够分化为骨骼肌细胞，平滑肌细胞，心肌细胞，血细胞，血管内皮细胞，脂肪细胞，成骨细胞，神经细胞，肝细胞和胰腺细胞，并且可用于组织的再生和 细胞和心脏衰竭，肝功能不全，肾功能不全，白血病，神经变性疾病，关节炎，糖尿病，动脉硬化等的治疗。