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公开(公告)号：US06676968B1
公开(公告)日：2004-01-13
申请号：US09889487
申请日：2001-07-18
申请人： Kiyoyuki Sakon , Masahiko Narasaki , Kentaro Fujinaga , Yoji Yamamoto , Hiroaki Mitsuhashi , Kazuoki Tsuruta , Hirofumi Tanabe , Yoshiaki Igarashi
发明人： Kiyoyuki Sakon , Masahiko Narasaki , Kentaro Fujinaga , Yoji Yamamoto , Hiroaki Mitsuhashi , Kazuoki Tsuruta , Hirofumi Tanabe , Yoshiaki Igarashi
IPC分类号： A61K922
CPC分类号： C07D211/26
摘要： A medicinal composition containing one or more compounds selected from the compounds represented by the following formula (I), salts of these compounds, solvates of these compounds and solvates of these salts and being capable of reducing the contact of the compounds with the components in the bile or pancreatic juice.
摘要翻译： 一种含有一种或多种选自下式（I）表示的化合物，这些化合物的盐，这些化合物的溶剂合物和这些盐的溶剂化物并能够减少化合物与组分的接触的药物组合物 胆汁或胰液
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公开(公告)号：US09028867B2
公开(公告)日：2015-05-12
申请号：US12063721
申请日：2006-08-17
申请人： Masahiko Narasaki , Tomoya Akutagawa , Reiko Oku
发明人： Masahiko Narasaki , Tomoya Akutagawa , Reiko Oku
IPC分类号： A61K9/20
CPC分类号： A61K9/2072 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/2086
摘要： The present invention provides a tablet comprising a plurality of drug-containing parts and at least one connecting part adhered to the drug-containing parts, and having a scored line capable of dividing the whole tablet on the connecting part; particularly, a coated tablet in which a connecting part and a coating layer have the same or different drug release controlling functions; a tablet having an insoluble coating on a drug-containing part having a scored line, wherein the drug-containing part has a structure or composition such that the drug is substantially released after the tablet is divided along the scored line and then ingested; and a tablet comprising a plurality of drug-containing parts and at least one connecting part adhered to the drug-containing parts, wherein at least two drug-containing parts have different compositions.In addition, the present invention provides a method of manufacturing a tablet, wherein a column comprising a plurality of columnar pharmaceutical composition layers having the same cross-section and laminated in the axial direction of the column is compression molded and then compression molded in a direction different from the axial direction of the column.
摘要翻译： 本发明提供了一种片剂，其包含多个药物含有部分和至少一个连接部分，所述至少一个连接部分粘附到所述药物包含部分，并且具有能够在所述连接部分上分割整个片剂的刻痕线; 特别是其中连接部分和涂层具有相同或不同的药物释放控制功能的包衣片剂; 在具有刻痕线的药物含有部分上具有不溶性涂层的片剂，其中所述药物含有部分具有使得所述药物在所述片剂沿着刻痕线分割然后摄取后基本上释放的结构或组成; 以及包含多个药物含有部分和至少一个粘附到所述药物含有部分的连接部分的片剂，其中至少两个药物含有部分具有不同的组成。 此外，本发明提供一种片剂的制造方法，其特征在于，将具有相同截面并在所述柱的轴向层叠的多个柱状药物组合物层的柱压缩成型，然后在 不同于柱的轴向。
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公开(公告)号：US20100092592A1
公开(公告)日：2010-04-15
申请号：US12527350
申请日：2008-02-19
IPC分类号： B29C43/34
CPC分类号： B30B15/30 , B30B7/04 , B30B11/007 , B30B11/027
摘要： A transfer board for transferring a columnar primary compression molded product whose two bottom faces may be bulged and which is supplied continuously one by one due to its own weight since the products continue vertically in a shooter into a mortar of a secondary tablet compression machine, for example, rotary tablet compression machine, in a state where the columnar direction is substantially horizontal, having at least an inclined portion having a plane-state inclined face, an input portion adjacent thereto, a portion for limiting drop of primary compression molded product, and a bottom plate provided at a lower part of the input portion, the inclined face being inclined so as to become lower toward the input portion, the inclined portion and the adjacent input portion performing a linear motion or rotary motion at a constant speed horizontally in a direction opposite to the input portion, and the input portion and the bottom plate being able to supply the primary compression molded product into the mortar of the secondary tablet compression machine while the columnar direction is kept substantially in a state of the horizontal direction.According to the above transfer board, the primary compression molded product forming layers in the columnar direction can be transferred for secondary compression from a direction different from that of the primary compression into a mortar of a secondary tablet compression machine by changing a direction of the primary compression molded product dropped and supplied with the columnar direction of the primary compression molded product substantially in the vertical direction so that the columnar direction is substantially horizontal and in a predetermined direction.
摘要翻译： 一种用于转印柱形初级压缩成型产品的转印板，其两个底面可以是凸出的，并且由于产品在射流器中垂直延伸到二次压片机的砂浆中，所以自身重量由于其自重而一个接一个地供应， 例如，旋转片式压缩机，在柱状方向基本上水平的状态下，至少具有平面状倾斜面的倾斜部分，与其相邻的输入部分，用于限制初级压缩成型产品的下降的部分，以及 设置在所述输入部的下部的底板，所述倾斜面朝向所述输入部倾斜成向下方倾斜，所述倾斜部和所述相邻的输入部在水平方向上以一定速度进行直线运动或旋转运动 方向与输入部分相反，并且输入部分和底板能够供应初级压模 d产品进入二次压片机的砂浆中，同时柱状方向基本保持在水平方向的状态。 根据上述转印板，柱状方向上的一次压缩成型品形成层可以从副压缩机的二次压缩方向向二次压缩机的砂浆输送二次压缩， 压缩成型品基本上沿垂直方向落下并供给一次压缩成型制品的柱状方向，使得柱状方向基本上水平并且沿预定方向。
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公开(公告)号：US10300021B2
公开(公告)日：2019-05-28
申请号：US12092852
申请日：2006-11-14
IPC分类号： A61K9/50 , A61K9/16 , A61K9/00 , A61K31/131 , A61K31/137 , A61K31/375 , A61K31/426
摘要： The present invention provides an intraorally rapidly disintegrating tablet that can be formed using an ordinary apparatus, that has hardness with no practical problem and that disintegrates rapidly with good feeling in the oral cavity.The present invention is intraorally rapidly disintegrating tablet produced by compression molding of a granule coated with a disintegrant, in which the granule contains a disintegrant also inside thereof and a drug except ambroxol hydrochloride inside and/or outside thereof.
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公开(公告)号：US09078807B2
公开(公告)日：2015-07-14
申请号：US12527084
申请日：2008-02-15
CPC分类号： A61J3/10 , B30B7/04 , B30B11/027 , B30B15/065
摘要： A tablet compression machine which can manufacture a tablet having a plurality of layers by applying secondary compression molding to a columnar primary compression molded product formed by a plurality of layers and whose two bottom faces may be bulged, comprising at least a mortar, an upper pestle, and a lower pestle, in which the mortar is substantially in a shape in which a part of a flat plate is punched by a closed curve in a direction perpendicular to a plane of the flat plate, the upper and lower pestles are in a shape fitted with an inner face of the mortar, a space formed by an inner face of the mortar, a lower face of the upper pestle, and an upper face of the lower pestle is in a shape of an intended tablet in the secondary compression molding, a dent formed by the inner face of the mortar and the upper face of the lower pestle can constitute a shape suitable for receiving the primary compression molded product, and a direction of the secondary compression molding is different from the compression molding direction of the primary compression molded product. According to such a tablet compression machine, a multilayer tablet in a shape having a multilayer structure and not limited to columnar can be manufactured.
摘要翻译： 一种片式压缩机，其可以通过对由多层形成并且其两个底面可以隆起的柱状初级压缩成型品进行二次压缩成型制造具有多层的片剂，所述片状压片机的两个底面可以隆起，至少包括研钵，上杵 ，以及下杵，其中，所述砂浆基本上为平板的一部分在与所述平板的平面垂直的方向上由闭合曲线冲压的形状，所述上下杵为形状 装配有砂浆的内表面，由研钵的内表面形成的空间，上杵的下表面和下杵的上表面在二次压缩成型中为预期的片剂的形状， 由砂浆的内表面和下杵的上表面形成的凹陷可以构成适于接收初级压缩成型品的形状，二次压缩成型的方向不同 从初级压缩成型品的压缩成型方向。 根据这样的片压缩机，可以制造具有多层结构但不限于柱状的形状的多层片剂。
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公开(公告)号：US08029261B2
公开(公告)日：2011-10-04
申请号：US12527350
申请日：2008-02-19
IPC分类号： B29C43/34
CPC分类号： B30B15/30 , B30B7/04 , B30B11/007 , B30B11/027
摘要： A transfer board for transferring a columnar primary compression molded product which is supplied continuously one by one vertically in a shooter into a mortar of a secondary tablet compression machine, having at least an inclined portion having a plane-state inclined face, an input portion adjacent thereto, a portion for limiting drop of primary compression molded product, and a bottom plate provided at a lower part of the input portion, the inclined face being inclined so as to become lower toward the input portion, the inclined portion and the adjacent input portion performing a linear motion or rotary motion at a constant speed horizontally in a direction opposite to the input portion, and the input portion and the bottom plate being able to supply the primary compression molded product into the mortar of the secondary tablet compression machine while the columnar direction is kept substantially in a state of the horizontal direction.
摘要翻译： 一种用于转印柱形初级压缩成型产品的转印板，该柱状初级压缩成型品在射枪中垂直地连续供给到二次压片机的砂浆中，该至少一个倾斜部分具有平面状倾斜面，相邻的输入部分 用于限制一次压缩成型制品的下降的部分，以及设置在输入部的下部的底板，倾斜面朝向输入部倾斜成较低的倾斜部和相邻的输入部 在与输入部相反的方向上以恒定速度进行直线运动或旋转运动，并且输入部分和底板能够将主压缩模制产品供应到次级压片机的砂浆中，而柱状 方向基本保持在水平方向的状态。
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公开(公告)号：US20100092596A1
公开(公告)日：2010-04-15
申请号：US12527084
申请日：2008-02-15
IPC分类号： B30B11/02
CPC分类号： A61J3/10 , B30B7/04 , B30B11/027 , B30B15/065
摘要： A tablet compression machine which can manufacture a tablet having a plurality of layers by applying secondary compression molding to a columnar primary compression molded product formed by a plurality of layers and whose two bottom faces may be bulged, comprising at least a mortar, an upper pestle, and a lower pestle, in which the mortar is substantially in a shape in which a part of a flat plate is punched by a closed curve in a direction perpendicular to a plane of the flat plate, the upper and lower pestles are in a shape fitted with an inner face of the mortar, a space formed by an inner face of the mortar, a lower face of the upper pestle, and an upper face of the lower pestle is in a shape of an intended tablet in the secondary compression molding, a dent formed by the inner face of the mortar and the upper face of the lower pestle can constitute a shape suitable for receiving the primary compression molded product, and a direction of the secondary compression molding is different from the compression molding direction of the primary compression molded product. According to such a tablet compression machine, a multilayer tablet in a shape having a multilayer structure and not limited to columnar can be manufactured.
摘要翻译： 一种片式压缩机，其可以通过对由多层形成并且其两个底面可以隆起的柱状初级压缩成型品进行二次压缩成型制造具有多层的片剂，所述片状压片机的两个底面可以隆起，至少包括研钵，上杵 ，以及下杵，其中，所述砂浆基本上为平板的一部分在与所述平板的平面垂直的方向上由闭合曲线冲压的形状，所述上下杵为形状 装配有砂浆的内表面，由研钵的内表面形成的空间，上杵的下表面和下杵的上表面在二次压缩成型中为预期的片剂的形状， 由砂浆的内表面和下杵的上表面形成的凹陷可以构成适于接收初级压缩成型品的形状，二次压缩成型的方向不同 从初级压缩成型品的压缩成型方向。 根据这样的片压缩机，可以制造具有多层结构但不限于柱状的形状的多层片剂。
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公开(公告)号：US09511029B2
公开(公告)日：2016-12-06
申请号：US12562674
申请日：2009-09-18
IPC分类号： A61K9/16 , A61K9/50 , A61K9/00 , A61K31/131 , A61K31/137 , A61K31/375 , A61K31/426
CPC分类号： A61K9/5026 , A61K9/0056 , A61K9/1635 , A61K31/131 , A61K31/137 , A61K31/375 , A61K31/426
摘要： The present invention provides an intraorally rapidly disintegrating tablet that can be formed using an ordinary apparatus, that has hardness with no practical problem and that disintegrates rapidly with good feeling in the oral cavity.The present invention is intraorally rapidly disintegrating tablet produced by compression molding of a granule coated with a disintegrant, in which the granule contains a disintegrant also inside thereof and a drug except ambroxol hydrochloride inside and/or outside thereof.
摘要翻译： 本发明是通过压缩成型包覆有崩解剂的颗粒制成的口腔内快速崩解片剂，其中颗粒中还含有崩解剂，以及在其内部和/或外部含有盐酸氨溴索的药物。
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公开(公告)号：US20100009004A1
公开(公告)日：2010-01-14
申请号：US12562674
申请日：2009-09-18
CPC分类号： A61K9/5026 , A61K9/0056 , A61K9/1635 , A61K31/131 , A61K31/137 , A61K31/375 , A61K31/426
摘要： The present invention provides an intraorally rapidly disintegrating tablet that can be formed using an ordinary apparatus, that has hardness with no practical problem and that disintegrates rapidly with good feeling in the oral cavity.The present invention is intraorally rapidly disintegrating tablet produced by compression molding of a granule coated with a disintegrant, in which the granule contains a disintegrant also inside thereof and a drug except ambroxol hydrochloride inside and/or outside thereof.
摘要翻译： 本发明提供一种能够使用普通装置形成的口腔内快速崩解片，其具有没有实际问题的硬度，并且在口腔中具有良好的感觉快速崩解。 本发明是通过压缩成型包覆有崩解剂的颗粒制成的口腔内快速崩解片剂，其中颗粒中还含有崩解剂，以及在其内部和/或外部含有盐酸氨溴索的药物。
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公开(公告)号：US20090155361A1
公开(公告)日：2009-06-18
申请号：US12063951
申请日：2006-08-18
申请人： Masahiko Narasaki , Tomoya Akutagawa , Reiko Oku
发明人： Masahiko Narasaki , Tomoya Akutagawa , Reiko Oku
CPC分类号： A61K9/2072 , A61K9/209 , A61K9/2866
摘要： A tablet which is either a two-layer tablet comprising a layer A and a layer B or a three-layer tablet comprising a layer A, a layer B and a layer C in that order, wherein the layer B is a medicinal additive layer, the layer A and the layer C are drug layers that are segmented on the layer B, and the sections of the layer A and the layer C are held on the layer B and contain either the same or different drugs. Also, a scored tablet wherein splitting at one of the score lines produces two fragments with equal drug contents and splitting at the other score line produces two fragments with unequal drug contents. In addition, a scored tablet wherein splitting at the score lines exposes cross-sections with different drug release-controlling functions.
摘要翻译： 片剂，其为依次层叠A层和B层的双层片剂或包含A层，B层和C层的三层片剂，其中，B层为药用添加剂层， 层A和层C是分层在层B上的药物层，层A和层C的部分保持在层B上并含有相同或不同的药物。 另外，一个刻痕片，其中一条记分线上的分裂产生具有相同药物含量的两个片段，并且在另一个刻痕线处分裂产生具有不相等药物含量的两个片段。 另外，在刻痕线处分割的刻痕片暴露具有不同药物释放控制功能的横截面。
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