公开(公告)号：US5693340A

公开(公告)日：1997-12-02

申请号：US727314

申请日：1996-10-08

申请人： Klaus Harth ,  Hartmut Hibst ,  Juergen Dembowski ,  Reinhard Spengler ,  Ernst Flaig

发明人： Klaus Harth ,  Hartmut Hibst ,  Juergen Dembowski ,  Reinhard Spengler ,  Ernst Flaig

IPC分类号： A61K9/32 ,  A61K9/22 ,  A61K9/28 ,  A61K9/50 ,  A61K9/52 ,  A61K47/34 ,  A61K9/16 ,  A61K9/30

CPC分类号： A61K9/5031 ,  A61K9/5089

摘要： A novel delayed-release form for pharmaceutical active compounds, characterized by a core containing the active compound and a diffusion-inhibiting, adhesive coating layer having a thickness in the range from 0.01 to 10 .mu.m, consisting of a chemical network which has been applied to the support in a plasma-assisted chemical deposition process, and a process for its production are described.

摘要翻译： 一种用于药物活性化合物的新型延迟释放形式，其特征在于含有活性化合物的核心和具有0.01至10μm的厚度的扩散抑制性粘合剂涂层，其由已应用的化学网络组成 涉及等离子体辅助化学沉积工艺中的载体，并描述了其生产方法。

公开(公告)号：US5364635A

公开(公告)日：1994-11-15

申请号：US97057

申请日：1993-07-27

申请人： Helmut Fricke ,  Thomas Moest ,  Ernst Flaig

发明人： Helmut Fricke ,  Thomas Moest ,  Ernst Flaig

IPC分类号： A61K9/16 ,  A61K31/275

CPC分类号： A61K9/1688 ,  A61K31/275

摘要： A solid drug form containing not less than 90% by weight verapamil is produced by granulating at from 30.degree. to 55.degree. C. with a little water, drying and, where appropriate, conventional tableting or by pelleting, in which case the granules obtained as described are, after cooling, moistened once again and compacted in a granulating mixer at from 30.degree. to 55.degree. C. and are dried.

摘要翻译： 含有不少于90％（重量）维拉帕米的固体药物通过用少量水在30-55℃进行造粒，干燥和适当时通过造粒或通过造粒将其制成为 冷却后再次润湿，在30〜55℃的造粒混合机中压实，并干燥。