公开(公告)号：US08003787B2

公开(公告)日：2011-08-23

申请号：US12126437

申请日：2008-05-23

申请人： Knut Eis ,  Olaf Prien ,  Ulrich Lücking ,  Judith Günther ,  Dieter Zopf ,  Dirk Brohm ,  Verena Vöhringer ,  Elisabeth Woltering ,  Hartmut Beck ,  Mario Lobell ,  Volkhart Min-Jian Li ,  Susanne Greschat

发明人： Knut Eis ,  Olaf Prien ,  Ulrich Lücking ,  Judith Günther ,  Dieter Zopf ,  Dirk Brohm ,  Verena Vöhringer ,  Elisabeth Woltering ,  Hartmut Beck ,  Mario Lobell ,  Volkhart Min-Jian Li ,  Susanne Greschat

IPC分类号： C07D239/86

CPC分类号： C07D239/86 ,  C07D215/44 ,  C07D409/04

摘要： The present invention relates to a quinoline or quinazoline derivative having the general formula (A): in which R3, R4, W, Y and Q are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).

摘要翻译： 本发明涉及具有通式（A）的喹啉或喹唑啉衍生物：其中R3，R4，W，Y和Q在说明书和权利要求中表示，通式（A）的化合物的用途， 用于治疗各种疾病，以及制备通式（A）的化合物。

公开(公告)号：US07750000B2

公开(公告)日：2010-07-06

申请号：US11514308

申请日：2006-09-01

申请人： Olaf Prien ,  Stuart James Ince ,  Knut Eis ,  Christoph Huwe ,  Ulrich Lücking ,  Rolf Jautelat ,  Ulrich Zügel ,  Judith Günther ,  Benjamin Bader ,  Manfred Husemann ,  Karina Schuck

发明人： Olaf Prien ,  Stuart James Ince ,  Knut Eis ,  Christoph Huwe ,  Ulrich Lücking ,  Rolf Jautelat ,  Ulrich Zügel ,  Judith Günther ,  Benjamin Bader ,  Manfred Husemann ,  Karina Schuck

IPC分类号： A61K31/4985 ,  A61K31/5355 ,  C07D487/04 ,  C07D413/12 ,  A61P3/10 ,  A61P11/06 ,  A61P29/00 ,  A61P17/06 ,  A61P17/00

CPC分类号： C07D487/04

摘要： The invention relates to novel inhibitors of kinases, and pharmaceutical compositions comprising them. The inhibitors are substituted imidazo[1,2b]pyridazines.

摘要翻译： 本发明涉及新型的激酶抑制剂和包含它们的药物组合物。 抑制剂是取代的咪唑并[1,2b]哒嗪。

公开(公告)号：US09499547B2

公开(公告)日：2016-11-22

申请号：US14342977

申请日：2012-09-05

申请人： Knut Eis ,  Florian Puehler ,  Ludwig Zorn ,  Arne Scholz ,  Philip Lienau ,  Mark Jean Gnoth ,  Ulf Bömer ,  Judith Günther ,  Marion Hitchcock

发明人： Knut Eis ,  Florian Puehler ,  Ludwig Zorn ,  Arne Scholz ,  Philip Lienau ,  Mark Jean Gnoth ,  Ulf Bömer ,  Judith Günther ,  Marion Hitchcock

IPC分类号： C07D487/04 ,  A61K31/5025 ,  A61K31/5377 ,  A61K45/06

CPC分类号： C07D487/04 ,  A61K31/5025 ,  A61K31/5377 ,  A61K45/06

摘要： The present invention relates to amino-substituted imidazopyridazine compounds of general formula (I): in which A, R1, R3 and n are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

公开(公告)号：US09730929B2

公开(公告)日：2017-08-15

申请号：US14123511

申请日：2012-05-30

申请人： Knut Eis ,  Florian Pühler ,  Ludwig Zorn ,  Arne Scholz ,  Philip Lienau ,  Mark Jean Gnoth ,  Ulf Bömer ,  Judith Günther ,  Jörg Fanghänel ,  Daniel Korr

发明人： Knut Eis ,  Florian Pühler ,  Ludwig Zorn ,  Arne Scholz ,  Philip Lienau ,  Mark Jean Gnoth ,  Ulf Bömer ,  Judith Günther ,  Jörg Fanghänel ,  Daniel Korr

IPC分类号： C07D487/04 ,  A61K31/5025 ,  C07D519/00 ,  A61K45/06

CPC分类号： A61K31/5025 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00

摘要： The present invention relates to substituted aminoimidazopyridazine compounds of general formula (I): in which A, R1, R2, R3 and R4 are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

公开(公告)号：US09284319B2

公开(公告)日：2016-03-15

申请号：US14129043

申请日：2012-06-21

申请人： Knut Eis ,  Florian Pühler ,  Ludwig Zorn ,  Arne Scholz ,  Philip Lienau ,  Mark Jean Gnoth ,  Ulf Bömer ,  Judith Günther ,  Jörg Fanghänel ,  Daniel Korr

发明人： Knut Eis ,  Florian Pühler ,  Ludwig Zorn ,  Arne Scholz ,  Philip Lienau ,  Mark Jean Gnoth ,  Ulf Bömer ,  Judith Günther ,  Jörg Fanghänel ,  Daniel Korr

IPC分类号： A61K31/5025 ,  C07D487/04

CPC分类号： C07D487/04

摘要： The present invention relates to heterocyclyl aminoimidazopyridazine compounds of general formula (I): in which A, R1, R2, R3 and R4 are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

摘要翻译： 本发明涉及通式（I）的杂环基氨基咪唑并哒嗪化合物：其中A，R1，R2，R3和R4如权利要求中所定义，涉及制备所述化合物的方法，药物组合物和包含所述化合物的组合， 所述化合物用于制备用于治疗或预防疾病，特别是高增殖和/或血管生成障碍的药物组合物作为唯一试剂或与其它活性成分组合的用途。

公开(公告)号：US20140288069A1

公开(公告)日：2014-09-25

申请号：US14118519

申请日：2012-05-14

申请人： Knut Eis ,  Florian Pühler ,  Ludwig Zorn ,  Arne Scholz ,  Philip Lienau ,  Mark Jean Gnoth ,  Ulf Bömer ,  Judith Günther ,  Jörg Fanghänel ,  Daniel Korr

发明人： Knut Eis ,  Florian Pühler ,  Ludwig Zorn ,  Arne Scholz ,  Philip Lienau ,  Mark Jean Gnoth ,  Ulf Bömer ,  Judith Günther ,  Jörg Fanghänel ,  Daniel Korr

IPC分类号： C07D487/04 ,  A61K31/5377 ,  A61K31/5025

CPC分类号： C07D487/04 ,  A61K31/5025 ,  A61K31/5377 ,  C07D519/00

摘要： The present invention relates to amino imidazopyridazine compounds of general formula (I): in which A, R1, R2, R3 and R4 are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said 10 compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

摘要翻译： 本发明涉及通式（I）的氨基咪唑并哒嗪化合物：其中A，R 1，R 2，R 3和R 4如权利要求中所定义，涉及制备所述化合物的方法，药物组合物和包含所述10种化合物和 涉及用于制造用于治疗或预防疾病，特别是高增殖和/或血管生成障碍的药物组合物作为唯一试剂或与其它活性成分组合的用途。

公开(公告)号：US20150038485A1

公开(公告)日：2015-02-05

申请号：US14129043

申请日：2012-06-21

申请人： Knut Eis ,  Florian Pühler ,  Ludwig Zorn ,  Arne Scholz ,  Philip Lienau ,  Mark Jean Gnoth ,  Ulf Bömer ,  Judith Günther ,  Jörg Fanghänel ,  Daniel Korr

发明人： Knut Eis ,  Florian Pühler ,  Ludwig Zorn ,  Arne Scholz ,  Philip Lienau ,  Mark Jean Gnoth ,  Ulf Bömer ,  Judith Günther ,  Jörg Fanghänel ,  Daniel Korr

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： The present invention relates to heterocyclyl aminoimidazopyridazine compounds of general formula (I): in which A, R1, R2, R3 and R4 are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

摘要翻译： 本发明涉及通式（I）的杂环基氨基咪唑并哒嗪化合物：其中A，R1，R2，R3和R4如权利要求中所定义，涉及制备所述化合物的方法，药物组合物和包含所述化合物的组合， 所述化合物用于制备用于治疗或预防疾病，特别是高增殖和/或血管生成障碍的药物组合物作为唯一试剂或与其它活性成分组合的用途。

公开(公告)号：US20140194430A1

公开(公告)日：2014-07-10

申请号：US14123511

申请日：2012-05-30

申请人： Knut Eis ,  Florian Pühler ,  Ludwig Zorn ,  Arne Scholz ,  Philip Lienau ,  Mark Jean Gnoth ,  Ulf Bömer ,  Judith Günther ,  Jörg Fanghänel ,  Daniel Korr

发明人： Knut Eis ,  Florian Pühler ,  Ludwig Zorn ,  Arne Scholz ,  Philip Lienau ,  Mark Jean Gnoth ,  Ulf Bömer ,  Judith Günther ,  Jörg Fanghänel ,  Daniel Korr

IPC分类号： A61K31/5025 ,  C07D487/04 ,  C07D519/00 ,  A61K45/06

CPC分类号： A61K31/5025 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00

摘要： The present invention relates to substituted aminoimidazopyridazine compounds of general formula (I): in which A, R1, R2, R3 and R4 are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

摘要翻译： 本发明涉及通式（I）的取代的氨基咪唑并哒嗪化合物：其中A，R 1，R 2，R 3和R 4如权利要求中所定义，涉及制备所述化合物的方法，药物组合物和包含所述化合物的组合， 所述化合物用于制备用于治疗或预防疾病，特别是高增殖和/或血管生成障碍的药物组合物作为唯一试剂或与其它活性成分组合的用途。