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    Method of treating a patient suffering from a bleeding disorder comprising administering an antibody against the A3-C1 of FVIII
    1.
    发明授权
    Method of treating a patient suffering from a bleeding disorder comprising administering an antibody against the A3-C1 of FVIII 有权
    治疗患有出血性疾病的患者的方法，包括对FVIII的A3-C1施用抗体

    公开(公告)号：US08586538B2

    公开(公告)日：2013-11-19

    申请号：US10512907

    申请日：2003-04-28

    申请人： Koenraad Mertens ,  Arend N. Bovenschen ,  Jan Voorberg ,  Manfred Rieger ,  Friedrich Scheiflinger

    发明人： Koenraad Mertens ,  Arend N. Bovenschen ,  Jan Voorberg ,  Manfred Rieger ,  Friedrich Scheiflinger

    IPC分类号： A61K38/36 ,  A61K38/37 ,  A61K39/00

    CPC分类号： C07K14/755 ,  A61K38/00 ,  A61K39/00 ,  C07K14/775 ,  C07K16/36 ,  C07K2317/622 ,  C07K2317/76

    摘要： The present invention concerns the use of peptides derived from and antibodies generated against Factor VIII and the inhibition of Factor VIII interaction with LRP. Furthermore, the present invention concerns a method to inhibit LRP interaction with Factor VIII as well as a method to decrease Factor VIII degradation and/or prolong Factor VIII half-life in a biological fluid and/or a method to treat patients suffering from a blood coagulation disorder, especially Haemophilia A. The present invention also concerns a pharmaceutical composition useful for the decrease of Factor VIII degradation in a biological fluid, the inhibition of Factor VIII interaction with LRP, and/or the prolongation of Factor VIII half-life in a biological fluid for treatment of a blood coagulation disorder, especially Haemophilia A.

    摘要翻译： 本发明涉及使用衍生自针对因子VIII产生的抗体和针对因子VIII与LRP的相互作用的抑制。 此外，本发明涉及抑制与因子VIII的LRP相互作用的方法以及降低生物流体中因子VIII降解和/或延长因子VIII半衰期的方法和/或治疗患有血液的患者的方法 凝血障碍，特别是血友病A.本发明还涉及可用于降低生物流体中因子VIII降解，抑制因子VIII与LRP的相互作用的药物组合物和/或因子VIII半衰期延长 用于治疗凝血障碍的生物流体，特别是血友病。