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    Benzimidazolone carboxylic acid derivatives
    2.
    发明授权
    Benzimidazolone carboxylic acid derivatives 失效
    苯并咪唑酮羧酸衍生物

    公开(公告)号：US07595329B2

    公开(公告)日：2009-09-29

    申请号：US11153757

    申请日：2005-06-14

    申请人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    发明人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    IPC分类号： A61K31/445 ,  C07D401/12

    CPC分类号： C07D401/12 ,  C07D211/26 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14

    摘要： This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 receptor activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders such as cardiac failure and heart arrhythmia, diabetes and apnea syndrome.

    摘要翻译： 本发明涉及式（I）化合物：其中R 1，R 2，R 3，A和m各自如本文所述，或其药学上可接受的盐或溶剂化物，以及含有这些化合物的组合物和这些化合物在治疗中的用途 由5-HT4受体活性介导的病症，例如但不限于胃食管反流病，胃肠道疾病，胃动力障碍，非溃疡性消化不良，功能性消化不良，肠易激综合征（IBS），便秘，消化不良，食道炎， 胃肠疾病，恶心，中枢神经系统疾病，阿尔茨海默病，认知障碍，呕吐，偏头痛，神经系统疾病，疼痛，心血管疾病如心力衰竭和心律失常，糖尿病和呼吸暂停综合征。

    Benzimidazolone Carboxylic Acid Derivatives
    3.
    发明申请
    Benzimidazolone Carboxylic Acid Derivatives 审中-公开
    苯并咪唑酮羧酸衍生物

    公开(公告)号：US20080108660A1

    公开(公告)日：2008-05-08

    申请号：US11971265

    申请日：2008-01-09

    申请人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    发明人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    IPC分类号： A61K31/445 ,  C07D403/02 ,  A61P1/00 ,  C07D211/06 ,  A61K31/4164

    CPC分类号： C07D401/12 ,  C07D211/26 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14

    摘要： This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 receptor activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageal disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders such as cardiac failure and heart arrhythmia, diabetes and apnea syndrome.

    摘要翻译： 本发明涉及式（I）化合物：其中R 1，R 2，R 3，A和m各自如上所述 本文或其药学上可接受的盐或溶剂合物，以及含有这些化合物的组合物以及这些化合物在治疗由5-HT 4受体活性介导的病症中的用途，所述活性例如但不限于， 胃食管反流病，胃肠道疾病，胃动力障碍，非溃疡性消化不良，功能性消化不良，肠易激综合征（IBS），便秘，消化不良，食管炎，胃食管疾病，恶心，中枢神经系统疾病，阿尔茨海默病，认知障碍，呕吐， 偏头痛，神经系统疾病，疼痛，心血管疾病如心力衰竭和心律失常，糖尿病和呼吸暂停综合征。

    Benzimidazolone carboxylic acid derivatives
    4.
    发明授权
    Benzimidazolone carboxylic acid derivatives 失效
    苯并咪唑酮羧酸衍生物

    公开(公告)号：US07737163B2

    公开(公告)日：2010-06-15

    申请号：US11153766

    申请日：2005-06-14

    申请人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    发明人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    IPC分类号： A61K31/445 ,  C07D401/12

    CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14

    摘要： This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 receptor activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders such as cardiac failure and heart arrhythmia, diabetes and apnea syndrome.

    摘要翻译： 本发明涉及式（I）化合物：其中R 1，R 2，R 3，A和m各自如本文所述，或其药学上可接受的盐或溶剂化物，以及含有这些化合物的组合物和这些化合物在治疗中的用途 由5-HT4受体活性介导的病症，例如但不限于胃食管反流病，胃肠道疾病，胃动力障碍，非溃疡性消化不良，功能性消化不良，肠易激综合征（IBS），便秘，消化不良，食道炎， 胃肠疾病，恶心，中枢神经系统疾病，阿尔茨海默病，认知障碍，呕吐，偏头痛，神经系统疾病，疼痛，心血管疾病如心力衰竭和心律失常，糖尿病和呼吸暂停综合征。

    Benzimidazolone carboxylic acid derivatives
    6.
    发明申请
    Benzimidazolone carboxylic acid derivatives 失效
    苯并咪唑酮羧酸衍生物

    公开(公告)号：US20050277672A1

    公开(公告)日：2005-12-15

    申请号：US11153766

    申请日：2005-06-14

    申请人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    发明人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    IPC分类号： A61K31/4184 ,  A61K31/454 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D43/02

    CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14

    摘要： This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 receptor activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders such as cardiac failure and heart arrhythmia, diabetes and apnea syndrome.

    摘要翻译： 本发明涉及式（I）化合物：其中R 1，R 2，R 3，A和m各自如上所述 本文或其药学上可接受的盐或溶剂合物，以及含有这些化合物的组合物以及这些化合物在治疗由5-HT 4受体活性介导的病症中的用途，所述活性例如但不限于， 胃食管反流病，胃肠道疾病，胃动力障碍，非溃疡性消化不良，功能性消化不良，肠易激综合征（IBS），便秘，消化不良，食管炎，胃肠疾病，恶心，中枢神经系统疾病，阿尔茨海默病，认知障碍，呕吐， 偏头痛，神经系统疾病，疼痛，心血管疾病如心力衰竭和心律失常，糖尿病和呼吸暂停综合征。

    Benzimidazolone compounds having 5-HT4 receptor agonistic activity
    8.
    发明授权
    Benzimidazolone compounds having 5-HT4 receptor agonistic activity 有权
    具有5-HT 4受体激动活性的苯并咪唑酮化合物

    公开(公告)号：US07776885B2

    公开(公告)日：2010-08-17

    申请号：US10933629

    申请日：2004-09-02

    申请人： Yasuhiro Katsu ,  Satoru Iguchi ,  Hiroki Sone ,  Chikara Uchida ,  Takashi Kojima

    发明人： Yasuhiro Katsu ,  Satoru Iguchi ,  Hiroki Sone ,  Chikara Uchida ,  Takashi Kojima

    IPC分类号： A61K31/454 ,  C07D471/04

    CPC分类号： C07D413/14 ,  C04B35/632 ,  C07D401/12 ,  C07D405/06 ,  C07D405/14

    摘要： This invention provides a compound of the formula (I): or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and the use of such compounds for the manufacture of medicament for gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders, cardiac failure, heart arrhythmia, diabetes and apnea syndrome. These compounds have 5-HT4 receptor agonistic activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans.

    摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐，以及含有这些化合物的组合物以及这些化合物在制备胃食管反流疾病，胃肠道疾病，胃动力障碍，非溃疡的药物中的用途 消化不良，功能性消化不良，肠易激综合征（IBS），便秘，消化不良，食管炎，胃食管疾病，恶心，中枢神经系统疾病，阿尔茨海默病，认知障碍，呕吐，偏头痛，神经系统疾病，疼痛，心血管疾病，心力衰竭，心脏 心律失常，糖尿病和呼吸暂停综合征。 这些化合物具有5-HT 4受体激动活性，因此可用于治疗哺乳动物特别是人类的胃食管反流病，非溃疡性消化不良，功能性消化不良，肠易激综合征等。

    Benzimidazolone Compounds Having 5-HT4 Receptor Agonistic Activity
    9.
    发明申请
    Benzimidazolone Compounds Having 5-HT4 Receptor Agonistic Activity 审中-公开
    具有5-HT4受体激动活性的苯并咪唑酮化合物

    公开(公告)号：US20100273794A1

    公开(公告)日：2010-10-28

    申请号：US12831713

    申请日：2010-07-07

    申请人： Yasuhiro Katsu ,  Satoru Iguchi ,  Hiroki Sone ,  Chikara Uchida ,  Takashi Kojima

    发明人： Yasuhiro Katsu ,  Satoru Iguchi ,  Hiroki Sone ,  Chikara Uchida ,  Takashi Kojima

    IPC分类号： A61K31/5377 ,  C07D211/26 ,  A61K31/454 ,  C07D413/14 ,  A61P1/04 ,  A61P1/00 ,  A61P9/00 ,  A61P25/06 ,  A61P25/28 ,  A61P29/00

    CPC分类号： C07D413/14 ,  C04B35/632 ,  C07D401/12 ,  C07D405/06 ,  C07D405/14

    摘要： This invention provides a compound of the formula (I): or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and the use of such compounds for the manufacture of medicament for gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders, cardiac failure, heart arrhythmia, diabetes and apnea syndrome.These compounds have 5-HT4 receptor agonistic activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans.

    摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐，以及含有这些化合物的组合物以及这些化合物在制备胃食管反流疾病，胃肠道疾病，胃动力障碍，非溃疡的药物中的用途 消化不良，功能性消化不良，肠易激综合征（IBS），便秘，消化不良，食管炎，胃食管疾病，恶心，中枢神经系统疾病，阿尔茨海默病，认知障碍，呕吐，偏头痛，神经系统疾病，疼痛，心血管疾病，心力衰竭，心脏 心律失常，糖尿病和呼吸暂停综合征。 这些化合物具有5-HT 4受体激动活性，因此可用于治疗哺乳动物特别是人类的胃食管反流病，非溃疡性消化不良，功能性消化不良，肠易激综合征等。

    Oxyindole derivatives
    10.
    发明申请
    Oxyindole derivatives 失效
    氧吲哚衍生物

    公开(公告)号：US20060194842A1

    公开(公告)日：2006-08-31

    申请号：US11360095

    申请日：2006-02-22

    申请人： Chikara Uchida ,  Hiroki Sone ,  Kiyoshi Kawamura

    发明人： Chikara Uchida ,  Hiroki Sone ,  Kiyoshi Kawamura

    IPC分类号： A61K31/454 ,  C07D417/14 ,  C07D413/14 ,  C07D403/14

    CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14

    摘要： This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: A, R1, R2, R3, R4 and R5 are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 agonistic activity such as, but not limited to, as gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageal disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders, cardiac failure, heart arrhythmia, diabetes or apnea syndrome.

    摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中：A，R 1，R 2，R 3， SUP，R 4和R 5各自如本文所述或其药学上可接受的盐，以及含有这些化合物的组合物和这些化合物在治疗病症中的用途 由5-HT 4激动剂活性介导，例如但不限于胃食管反流疾病，胃肠道疾病，胃动力障碍，非溃疡性消化不良，功能性消化不良，肠易激综合征（IBS）， 便秘，消化不良，食管炎，胃食管疾病，恶心，中枢神经系统疾病，阿尔茨海默病，认知障碍，呕吐，偏头痛，神经系统疾病，疼痛，心血管疾病，心力衰竭，心律失常，糖尿病或呼吸暂停综合征。