利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

12 条记录 (耗时 0.051 秒)

    Benzimidazolone carboxylic acid derivatives
    1.
    发明授权
    Benzimidazolone carboxylic acid derivatives 失效
    苯并咪唑酮羧酸衍生物

    公开(公告)号：US07595329B2

    公开(公告)日：2009-09-29

    申请号：US11153757

    申请日：2005-06-14

    申请人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    发明人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    IPC分类号： A61K31/445 ,  C07D401/12

    CPC分类号： C07D401/12 ,  C07D211/26 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14

    摘要： This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 receptor activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders such as cardiac failure and heart arrhythmia, diabetes and apnea syndrome.

    摘要翻译： 本发明涉及式（I）化合物：其中R 1，R 2，R 3，A和m各自如本文所述，或其药学上可接受的盐或溶剂化物，以及含有这些化合物的组合物和这些化合物在治疗中的用途 由5-HT4受体活性介导的病症，例如但不限于胃食管反流病，胃肠道疾病，胃动力障碍，非溃疡性消化不良，功能性消化不良，肠易激综合征（IBS），便秘，消化不良，食道炎， 胃肠疾病，恶心，中枢神经系统疾病，阿尔茨海默病，认知障碍，呕吐，偏头痛，神经系统疾病，疼痛，心血管疾病如心力衰竭和心律失常，糖尿病和呼吸暂停综合征。

    Benzimidazolone Carboxylic Acid Derivatives
    2.
    发明申请
    Benzimidazolone Carboxylic Acid Derivatives 审中-公开
    苯并咪唑酮羧酸衍生物

    公开(公告)号：US20080108660A1

    公开(公告)日：2008-05-08

    申请号：US11971265

    申请日：2008-01-09

    申请人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    发明人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    IPC分类号： A61K31/445 ,  C07D403/02 ,  A61P1/00 ,  C07D211/06 ,  A61K31/4164

    CPC分类号： C07D401/12 ,  C07D211/26 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14

    摘要： This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 receptor activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageal disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders such as cardiac failure and heart arrhythmia, diabetes and apnea syndrome.

    摘要翻译： 本发明涉及式（I）化合物：其中R 1，R 2，R 3，A和m各自如上所述 本文或其药学上可接受的盐或溶剂合物，以及含有这些化合物的组合物以及这些化合物在治疗由5-HT 4受体活性介导的病症中的用途，所述活性例如但不限于， 胃食管反流病，胃肠道疾病，胃动力障碍，非溃疡性消化不良，功能性消化不良，肠易激综合征（IBS），便秘，消化不良，食管炎，胃食管疾病，恶心，中枢神经系统疾病，阿尔茨海默病，认知障碍，呕吐， 偏头痛，神经系统疾病，疼痛，心血管疾病如心力衰竭和心律失常，糖尿病和呼吸暂停综合征。

    Benzimidazolone carboxylic acid derivatives
    3.
    发明授权
    Benzimidazolone carboxylic acid derivatives 失效
    苯并咪唑酮羧酸衍生物

    公开(公告)号：US07737163B2

    公开(公告)日：2010-06-15

    申请号：US11153766

    申请日：2005-06-14

    申请人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    发明人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    IPC分类号： A61K31/445 ,  C07D401/12

    CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14

    摘要： This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 receptor activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders such as cardiac failure and heart arrhythmia, diabetes and apnea syndrome.

    摘要翻译： 本发明涉及式（I）化合物：其中R 1，R 2，R 3，A和m各自如本文所述，或其药学上可接受的盐或溶剂化物，以及含有这些化合物的组合物和这些化合物在治疗中的用途 由5-HT4受体活性介导的病症，例如但不限于胃食管反流病，胃肠道疾病，胃动力障碍，非溃疡性消化不良，功能性消化不良，肠易激综合征（IBS），便秘，消化不良，食道炎， 胃肠疾病，恶心，中枢神经系统疾病，阿尔茨海默病，认知障碍，呕吐，偏头痛，神经系统疾病，疼痛，心血管疾病如心力衰竭和心律失常，糖尿病和呼吸暂停综合征。

    Benzimidazolone carboxylic acid derivatives
    5.
    发明申请
    Benzimidazolone carboxylic acid derivatives 失效
    苯并咪唑酮羧酸衍生物

    公开(公告)号：US20050277672A1

    公开(公告)日：2005-12-15

    申请号：US11153766

    申请日：2005-06-14

    申请人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    发明人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    IPC分类号： A61K31/4184 ,  A61K31/454 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D43/02

    CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14

    摘要： This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 receptor activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders such as cardiac failure and heart arrhythmia, diabetes and apnea syndrome.

    摘要翻译： 本发明涉及式（I）化合物：其中R 1，R 2，R 3，A和m各自如上所述 本文或其药学上可接受的盐或溶剂合物，以及含有这些化合物的组合物以及这些化合物在治疗由5-HT 4受体活性介导的病症中的用途，所述活性例如但不限于， 胃食管反流病，胃肠道疾病，胃动力障碍，非溃疡性消化不良，功能性消化不良，肠易激综合征（IBS），便秘，消化不良，食管炎，胃肠疾病，恶心，中枢神经系统疾病，阿尔茨海默病，认知障碍，呕吐， 偏头痛，神经系统疾病，疼痛，心血管疾病如心力衰竭和心律失常，糖尿病和呼吸暂停综合征。

    1,4-dihydropyridine compounds as bradykinin antagonists
    8.
    发明授权
    1,4-dihydropyridine compounds as bradykinin antagonists 失效
    1,4-二氢吡啶化合物作为缓激肽拮抗剂

    公开(公告)号：US06653313B2

    公开(公告)日：2003-11-25

    申请号：US09903157

    申请日：2001-07-11

    申请人： Mitsuhiro Kawamura ,  Makoto Kawai ,  Yuji Shishido ,  Tomoki Kato ,  Yasuhiro Katsu ,  Takafumi Ikeda ,  Noriaki Murase

    发明人： Mitsuhiro Kawamura ,  Makoto Kawai ,  Yuji Shishido ,  Tomoki Kato ,  Yasuhiro Katsu ,  Takafumi Ikeda ,  Noriaki Murase

    IPC分类号： A61K31496

    CPC分类号： A61K31/46 ,  A61K31/496 ,  C07D451/04 ,  Y02A50/411

    摘要： The present invention relates to compounds of the formula wherein each A is independently halo; Y is —(CH2)m—, —C(O)— or —S(O)—; R1 and R2 are independently C1-4 alkyl; R3 is substituted azacycloalkyl etc.; R4 is phenyl substituted at the 2-position with a substituent selected from substituted C1-7 alkyl, substituted C1-7 alkoxy, amine, etc; R5 is hydrogen or C1-4 alkyl; m is 0, 1 or 2; and n is 0, 1, 2, 3, 4 or 5. The present invention also relates to pharmaceutical compositions containing such compounds and to the use of such compounds in the treatment and prevention of inflammation, asthma, allergic rhinitis, pain and other disorders.

    摘要翻译： 本发明涉及各种化合物，每个A独立地是卤素; Y是 - （CH 2）m - ， - C（O） - 或-S（O） - ; R 1和R 2独立地是C 1-4烷基; R 3是取代的氮杂环烷基等; R 4是在2-位上被取代基取代的C 1-7烷基，取代的C 1-7烷氧基，胺等取代的苯基; R 5是氢或C 1-4烷基; m为0,1或2; 本发明还涉及含有这些化合物的药物组合物以及这些化合物在治疗和预防炎症，哮喘，变应性鼻炎，疼痛和其它疾病中的用途 。

    Process for preparing 1,4-dihydropyridine compounds
    9.
    发明授权
    Process for preparing 1,4-dihydropyridine compounds 失效
    制备1,4-二氢吡啶化合物的方法

    公开(公告)号：US06649767B2

    公开(公告)日：2003-11-18

    申请号：US10224928

    申请日：2002-08-20

    申请人： Kunio Satake ,  Noriaki Murase

    发明人： Kunio Satake ,  Noriaki Murase

    IPC分类号： C07D21302

    CPC分类号： C07D417/06

    摘要： A process for preparing a 1,4-dihydropyridine compound comprising contacting an enamine compound and a compound having a structure of in the presence of a base; and treating the reaction mixture thus obtained in the presence of an acid or a combination of acids under mild reaction conditions. A resulting 1,4-dihydropyridine compound is useful as an anti-inflammatory agent or the like.

    摘要翻译： 一种制备1,4-二氢吡啶化合物的方法，包括使烯胺化合物和具有在碱存在下的结构的化合物接触; 并在温和的反应条件下，在酸或酸的组合存在下处理由此得到的反应混合物。 得到的1,4-二氢吡啶化合物可用作抗炎剂等。