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    Benzimidazolone carboxylic acid derivatives
    2.
    发明授权
    Benzimidazolone carboxylic acid derivatives 失效
    苯并咪唑酮羧酸衍生物

    公开(公告)号：US07595329B2

    公开(公告)日：2009-09-29

    申请号：US11153757

    申请日：2005-06-14

    申请人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    发明人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    IPC分类号： A61K31/445 ,  C07D401/12

    CPC分类号： C07D401/12 ,  C07D211/26 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14

    摘要： This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 receptor activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders such as cardiac failure and heart arrhythmia, diabetes and apnea syndrome.

    摘要翻译： 本发明涉及式（I）化合物：其中R 1，R 2，R 3，A和m各自如本文所述，或其药学上可接受的盐或溶剂化物，以及含有这些化合物的组合物和这些化合物在治疗中的用途 由5-HT4受体活性介导的病症，例如但不限于胃食管反流病，胃肠道疾病，胃动力障碍，非溃疡性消化不良，功能性消化不良，肠易激综合征（IBS），便秘，消化不良，食道炎， 胃肠疾病，恶心，中枢神经系统疾病，阿尔茨海默病，认知障碍，呕吐，偏头痛，神经系统疾病，疼痛，心血管疾病如心力衰竭和心律失常，糖尿病和呼吸暂停综合征。

    Benzimidazolone carboxylic acid derivatives
    3.
    发明授权
    Benzimidazolone carboxylic acid derivatives 失效
    苯并咪唑酮羧酸衍生物

    公开(公告)号：US07737163B2

    公开(公告)日：2010-06-15

    申请号：US11153766

    申请日：2005-06-14

    申请人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    发明人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    IPC分类号： A61K31/445 ,  C07D401/12

    CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14

    摘要： This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 receptor activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders such as cardiac failure and heart arrhythmia, diabetes and apnea syndrome.

    摘要翻译： 本发明涉及式（I）化合物：其中R 1，R 2，R 3，A和m各自如本文所述，或其药学上可接受的盐或溶剂化物，以及含有这些化合物的组合物和这些化合物在治疗中的用途 由5-HT4受体活性介导的病症，例如但不限于胃食管反流病，胃肠道疾病，胃动力障碍，非溃疡性消化不良，功能性消化不良，肠易激综合征（IBS），便秘，消化不良，食道炎， 胃肠疾病，恶心，中枢神经系统疾病，阿尔茨海默病，认知障碍，呕吐，偏头痛，神经系统疾病，疼痛，心血管疾病如心力衰竭和心律失常，糖尿病和呼吸暂停综合征。

    Benzimidazolone carboxylic acid derivatives
    5.
    发明申请
    Benzimidazolone carboxylic acid derivatives 失效
    苯并咪唑酮羧酸衍生物

    公开(公告)号：US20050277672A1

    公开(公告)日：2005-12-15

    申请号：US11153766

    申请日：2005-06-14

    申请人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    发明人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    IPC分类号： A61K31/4184 ,  A61K31/454 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D43/02

    CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14

    摘要： This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 receptor activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders such as cardiac failure and heart arrhythmia, diabetes and apnea syndrome.

    摘要翻译： 本发明涉及式（I）化合物：其中R 1，R 2，R 3，A和m各自如上所述 本文或其药学上可接受的盐或溶剂合物，以及含有这些化合物的组合物以及这些化合物在治疗由5-HT 4受体活性介导的病症中的用途，所述活性例如但不限于， 胃食管反流病，胃肠道疾病，胃动力障碍，非溃疡性消化不良，功能性消化不良，肠易激综合征（IBS），便秘，消化不良，食管炎，胃肠疾病，恶心，中枢神经系统疾病，阿尔茨海默病，认知障碍，呕吐， 偏头痛，神经系统疾病，疼痛，心血管疾病如心力衰竭和心律失常，糖尿病和呼吸暂停综合征。

    Benzimidazolone Carboxylic Acid Derivatives
    7.
    发明申请
    Benzimidazolone Carboxylic Acid Derivatives 审中-公开
    苯并咪唑酮羧酸衍生物

    公开(公告)号：US20080108660A1

    公开(公告)日：2008-05-08

    申请号：US11971265

    申请日：2008-01-09

    申请人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    发明人： Koji Ando ,  Satoru Iguchi ,  Noriaki Murase ,  Yoshinori Murata ,  Toyoharu Numata ,  Hiroki Sone ,  Chikara Uchida ,  Tatsuo Ueki

    IPC分类号： A61K31/445 ,  C07D403/02 ,  A61P1/00 ,  C07D211/06 ,  A61K31/4164

    CPC分类号： C07D401/12 ,  C07D211/26 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14

    摘要： This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 receptor activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageal disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders such as cardiac failure and heart arrhythmia, diabetes and apnea syndrome.

    摘要翻译： 本发明涉及式（I）化合物：其中R 1，R 2，R 3，A和m各自如上所述 本文或其药学上可接受的盐或溶剂合物，以及含有这些化合物的组合物以及这些化合物在治疗由5-HT 4受体活性介导的病症中的用途，所述活性例如但不限于， 胃食管反流病，胃肠道疾病，胃动力障碍，非溃疡性消化不良，功能性消化不良，肠易激综合征（IBS），便秘，消化不良，食管炎，胃食管疾病，恶心，中枢神经系统疾病，阿尔茨海默病，认知障碍，呕吐， 偏头痛，神经系统疾病，疼痛，心血管疾病如心力衰竭和心律失常，糖尿病和呼吸暂停综合征。

    Random number generating device
    9.
    发明授权
    Random number generating device 有权
    随机数生成装置

    公开(公告)号：US08521795B2

    公开(公告)日：2013-08-27

    申请号：US12452012

    申请日：2008-03-24

    申请人： Akio Fukushima ,  Hitoshi Kubota ,  Kay Yakushiji ,  Shinji Yuasa ,  Koji Ando

    发明人： Akio Fukushima ,  Hitoshi Kubota ,  Kay Yakushiji ,  Shinji Yuasa ,  Koji Ando

    IPC分类号： G06F7/58

    CPC分类号： G06F7/588

    摘要： A random number generating device is constructed such that it has improved random number generation rate and allows for construction of compact circuit with ease.The random number generating device includes a magnetoresistive element that has three layers consisting of a magnetization free layer, an interlayer, and a magnetization fixed layer, and has at least two resistance values depending on arrangement of magnetization in the magnetization free layer and the magnetization fixed layer, wherein the magnetoresistive element is subjected to be applied with a magnetization current so that the inversion probability of the magnetization free layer assumes a value between 0 and 1, through which the resistance value of the magnetoresistive element is extracted as random numbers.

    摘要翻译： 构造随机数生成装置，使其具有改善的随机数生成速率并且容易地构造紧凑电路。 该随机数生成装置包括具有由磁化自由层，中间层和磁化固定层构成的三层的磁致电阻元件，并且具有取决于磁化自由层的磁化排列和磁化固定的至少两个电阻值 层，其中磁阻元件经受施加磁化电流，使得磁化自由层的反转概率为0和1之间的值，磁阻元件的电阻值通过该值提取为随机数。

    Non-volatile memory element and method of operation therefor
    10.
    发明授权
    Non-volatile memory element and method of operation therefor 有权
    非易失性存储元件及其操作方法

    公开(公告)号：US07936631B2

    公开(公告)日：2011-05-03

    申请号：US12318823

    申请日：2009-01-09

    申请人： Vadym Zayets ,  Koji Ando

    发明人： Vadym Zayets ,  Koji Ando

    IPC分类号： G11C13/04

    CPC分类号： H01L29/66984 ,  G11C11/161 ,  G11C11/1659 ,  G11C11/1673 ,  G11C11/1675 ,  G11C13/06 ,  H01L29/868

    摘要： A very small magnetic tunnel junction is formed on a semiconductor p-i-n diode. Spin-polarized current which is generated by circular polarized light or elliptically-polarized light, is injected into a free layer of the magnetic tunnel junction so that magnetization direction (two opposite directions) in the free layer is changed based on the information, whereby information is stored in the memory element.

    摘要翻译： 在半导体p-i-n二极管上形成非常小的磁性隧道结。 由圆偏振光或椭圆偏振光产生的自旋极化电流被注入到磁性隧道结的自由层中，使得自由层中的磁化方向（两个相反的方向）基于信息而改变，由此信息 存储在存储元件中。