公开(公告)号：US20060076515A1

公开(公告)日：2006-04-13

申请号：US11239073

申请日：2005-09-30

申请人： Koji Matsuda ,  Kazuo Hiramoto ,  Kunio Moriyama

发明人： Koji Matsuda ,  Kazuo Hiramoto ,  Kunio Moriyama

IPC分类号： G21K5/10

CPC分类号： A61N5/1048 ,  A61N5/1043 ,  A61N5/1079 ,  A61N2005/1074 ,  A61N2005/1087

摘要： To ensure irradiation accuracy and safety, even when an irradiation device employing a different irradiation method is used, disclosed is herein a charged particle beam irradiation apparatus that irradiates an irradiation target with charged particle beams includes: a charged particle beam generator for generating the charged particle beams; a passive scattering irradiation device and a scanning irradiation device, both for irradiating the irradiation target with the charged particle beams; a beam transport system for transporting the charged particles beam extracted from the charged particle beam generator, to selected one of the two irradiation devices; and a central controller that modifies operating parameters on the charged particle beam generator, according to the irradiation method adopted for the selected irradiation device.

摘要翻译： 为了确保照射精度和安全性，即使使用采用不同的照射方式的照射装置，在此公开了一种带电粒子束照射被照射靶的带电粒子束照射装置，包括：带电粒子束发生器，用于产生带电粒子 梁; 被动散射照射装置和扫描照射装置，用于向照射目标照射带电粒子束; 用于将从带电粒子束发生器提取的带电粒子束传送到两个照射装置中的一个的光束传输系统; 以及根据所选择的照射装置采用的照射方法修改带电粒子束发生器的工作参数的中央控制器。

公开(公告)号：US20100171047A1

公开(公告)日：2010-07-08

申请号：US12729662

申请日：2010-03-23

申请人： Koji Matsuda ,  Kazuo Hiramoto ,  Kunio Moriyama

发明人： Koji Matsuda ,  Kazuo Hiramoto ,  Kunio Moriyama

IPC分类号： A61N5/10 ,  H01J37/04 ,  H05H13/04 ,  H05H13/00

CPC分类号： A61N5/1048 ,  A61N5/1043 ,  A61N5/1079 ,  A61N2005/1074 ,  A61N2005/1087

摘要： To ensure irradiation accuracy and safety, even when an irradiation device employing a different irradiation method is used, disclosed is herein a charged particle beam irradiation apparatus that irradiates an irradiation target with charged particle beams includes:a charged particle beam generator for generating the charged particle beams; a passive scattering irradiation device and a scanning irradiation device, both for irradiating the irradiation target with the charged particle beams; a beam transport system for transporting the charged particles beam extracted from the charged particle beam generator, to selected one of the two irradiation devices; and a central controller that modifies operating parameters on the charged particle beam generator, according to the irradiation method adopted for the selected irradiation device.

摘要翻译： 为了确保照射精度和安全性，即使使用采用不同的照射方式的照射装置，在此公开了一种带电粒子束照射被照射靶的带电粒子束照射装置，包括：带电粒子束发生器，用于产生带电粒子 梁; 被动散射照射装置和扫描照射装置，用于向照射目标照射带电粒子束; 用于将从带电粒子束发生器提取的带电粒子束传送到两个照射装置中的一个的光束传输系统; 以及根据所选择的照射装置采用的照射方法修改带电粒子束发生器的工作参数的中央控制器。

公开(公告)号：US07709818B2

公开(公告)日：2010-05-04

申请号：US11239073

申请日：2005-09-30

申请人： Koji Matsuda ,  Kazuo Hiramoto ,  Kunio Moriyama

发明人： Koji Matsuda ,  Kazuo Hiramoto ,  Kunio Moriyama

IPC分类号： A61N5/10

CPC分类号： A61N5/1048 ,  A61N5/1043 ,  A61N5/1079 ,  A61N2005/1074 ,  A61N2005/1087

摘要： To ensure irradiation accuracy and safety, even when an irradiation device employing a different irradiation method is used, disclosed is herein a charged particle beam irradiation apparatus that irradiates an irradiation target with charged particle beams includes: a charged particle beam generator for generating the charged particle beams; a passive scattering irradiation device and a scanning irradiation device, both for irradiating the irradiation target with the charged particle beams; a beam transport system for transporting the charged particles beam extracted from the charged particle beam generator, to selected one of the two irradiation devices; and a central controller that modifies operating parameters on the charged particle beam generator, according to the irradiation method adopted for the selected irradiation device.

摘要翻译： 为了确保照射精度和安全性，即使使用采用不同的照射方式的照射装置，在此公开了一种带电粒子束照射被照射靶的带电粒子束照射装置，包括：带电粒子束发生器，用于产生带电粒子 梁; 被动散射照射装置和扫描照射装置，用于向照射目标照射带电粒子束; 用于将从带电粒子束发生器提取的带电粒子束传送到两个照射装置中的一个的光束传输系统; 以及根据所选择的照射装置采用的照射方法修改带电粒子束发生器的工作参数的中央控制器。

公开(公告)号：US6087670A

公开(公告)日：2000-07-11

申请号：US365835

申请日：1999-08-03

申请人： Kazuo Hiramoto ,  Masumi Umezawa ,  Koji Matsuda

发明人： Kazuo Hiramoto ,  Masumi Umezawa ,  Koji Matsuda

IPC分类号： H05H7/04 ,  A61N5/10 ,  H05H7/10 ,  H05H13/04

CPC分类号： H05H13/04 ,  H05H7/10 ,  A61N2005/1087

摘要： A synchrotron type accelerator including a deflecting electromagnet arranged on a circulating orbit of a charged particle beam, four-pole divergence electromagnets and four-pole convergence electromagnets arranged on said circulating orbit. A high frequency applying unit arranged on the circulating orbit for applying a high frequency electromagnetic field to the charged particle beam circulating and for increasing an amplitude of betatron oscillation of the particle beam to a level above a stability limit of resonance. A first deflector for beam ejection arranged on the circulating orbit for deflecting the charged particle beam excited above the stability limit of the resonance by the high frequency applying unit and a second deflector for beam ejection arranged on the circulating orbit used in pairs with the first deflector for beam ejection for introducing the charged particle beam deflected by the first deflector for beam ejection into an ejected beam transporting system. The deflecting electromagnet and the second deflector for beam ejection are arranged in this order at downstream with respect to the first deflector for beam ejection, and the four-pole divergence electromagnets are arranged at downstream with respect to the first deflector for beam ejection and upstream with respect to the deflecting electromagnet and at downstream with respect to the deflecting electromagnet and upstream with respect to the second deflector for beam ejection.

摘要翻译： 包括设置在带电粒子束的循环轨道上的偏转电磁体的同步加速器型加速器，设置在所述循环轨道上的四极发散电磁体和四极收敛电磁体。 布置在循环轨道上的高频施加单元，用于将高频电磁场施加到带电粒子束循环，并将粒子束的贝塔振荡幅度提高到高于谐振稳定极限的水平。 用于射流喷射的第一偏转器，布置在循环轨道上，用于偏转由高频施加单元激发的高于谐振稳定极限的带电粒子束，以及布置在与第一偏转器成对使用的循环轨道上的用于射束的第二偏转器 用于射出用于引入由第一偏转器偏转的带电粒子束，用于射束射出到射出的束传输系统中。 用于射束的偏转电磁体和第二偏转器相对于第一偏转器在下游依次布置以用于射束，并且四极分支电磁体相对于第一偏转器布置在下游，用于射出射流，并且在上游具有 相对于偏转电磁体并且在相对于偏转电磁体的下游以及相对于第二偏转器的上游，用于射束。

公开(公告)号：US07755305B2

公开(公告)日：2010-07-13

申请号：US12129145

申请日：2008-05-29

申请人： Masumi Umezawa ,  Kazuo Hiramoto ,  Koji Matsuda

发明人： Masumi Umezawa ,  Kazuo Hiramoto ,  Koji Matsuda

IPC分类号： H05H13/04 ,  H05H7/10 ,  A61N5/10

CPC分类号： A61N5/10 ,  A61N2005/1074 ,  A61N2005/1087 ,  G21K1/043 ,  H05H7/10

摘要： A charged particle beam extraction system and method capable of shortening the irradiation time and increasing the number of patients treatable per unit time. The charged particle beam extraction system comprises a synchrotron for cyclically performing patterned operation including four steps of introducing, accelerating, extracting and decelerating an ion beam, an on/off switch for opening or closing connection between an RF knockout electrode and an RF power supply for applying RF power to the RF knockout electrode, and a timing controller for controlling on/off-timing of the on/off switch such that when extraction of the ion beam is stopped at least once during the extraction step of the synchrotron, an amount of the ion beam extracted from the synchrotron in one cycle is held substantially at a setting value.

摘要翻译： 一种带电粒子束提取系统和方法，其能够缩短照射时间并增加每单位时间可治疗的患者数量。 带电粒子束提取系统包括用于循环执行图案化操作的同步加速器，其包括引入，加速，提取和减速离子束的四个步骤，用于打开或关闭RF击穿电极和RF电源之间的连接的开/关开关， 将RF功率施加到RF击穿电极，以及定时控制器，用于控制开/关开关的接通/断开定时，使得当在同步加速器的提取步骤期间离子束的提取停止至少一次时， 在一个周期内从同步加速器提取的离子束基本保持在设定值。

公开(公告)号：US08637837B2

公开(公告)日：2014-01-28

申请号：US12892225

申请日：2010-09-28

申请人： Takayoshi Natori ,  Kunio Moriyama ,  Koji Matsuda

发明人： Takayoshi Natori ,  Kunio Moriyama ,  Koji Matsuda

IPC分类号： G21G5/00

CPC分类号： A61N5/1048 ,  A61N5/1037 ,  A61N5/1043 ,  A61N5/1064 ,  A61N2005/1087

摘要： A beam extraction process (interruption and restart) is appropriately performed when a failure occurs during irradiation of a spot group. A charged particle irradiation system includes a synchrotron 12 and a scanning irradiation unit 15 that scans an ion beam extracted from the synchrotron over a subject. The extraction of the ion beam from the synchrotron is stopped on the basis of a beam extraction stop command. Scanning magnets 5A and 5B are controlled to change a point (spot) to be irradiated with the ion beam, while the extraction of the ion beam is stopped. The extraction of the ion beam from the synchrotron is restarted after the change of the spot to be irradiated. When a relatively minor failure in which continuous irradiation would be possible occurs during irradiation of a certain spot with the beam, the extraction of the beam is not immediately stopped.

摘要翻译： 当点组的照射期间发生故障时，适当地执行光束提取处理（中断和重新启动）。 带电粒子照射系统包括同步加速器12和扫描照射单元15，扫描照射单元15扫描从对象上的同步加速器提取的离子束。 基于光束提取停止命令停止来自同步加速器的离子束的提取。 在停止提取离子束的同时，控制扫描磁体5A和5B来改变要用离子束照射的点（点）。 离子束从同步加速器的提取在被照射点改变后重新开始。 当在用光束照射某一点时可能发生连续照射的相对较小的故障，则梁的提取不会立即停止。

公开(公告)号：US07825388B2

公开(公告)日：2010-11-02

申请号：US11678300

申请日：2007-02-23

申请人： Hideaki Nihongi ,  Koji Matsuda ,  Kazuo Hiramoto ,  Hiroshi Akiyama

发明人： Hideaki Nihongi ,  Koji Matsuda ,  Kazuo Hiramoto ,  Hiroshi Akiyama

IPC分类号： H05H9/00

CPC分类号： G21K1/10 ,  A61N5/1048 ,  A61N5/1065 ,  A61N2005/1087 ,  A61N2005/1095 ,  A61N2005/1096 ,  H05H7/10

摘要： A charged particle beam irradiation system and a charged particle beam extraction method which can prevent erroneous irradiation of a charged particle beam in the direction of advance of the charged particle beam. The system and method are featured in stopping supply of an ion beam to one or more of a plurality of angle zones in each of which a target dose is attained, the angle zones being formed by dividing an RMW in a rotating direction thereof, and in allowing the supply of the ion beam to one or more other angle zones in each of which a target dose is not yet attained. The invention can easily adjust beam doses at various positions in an affected part of the patient body in the direction of advance of the ion beam, and can greatly reduce the probability of erroneous irradiation that the beam dose becomes excessive or deficient at the various positions within the affected part of the patient body in the direction of advance of the ion beam.

摘要翻译： 带电粒子束照射系统和带电粒子束提取方法，其可以防止带电粒子束沿着带电粒子束的前进方向的错误照射。 该系统和方法的特征在于停止向多个角区域中的一个或多个角度区域供应目标剂量，其中角度区域通过沿其旋转方向分割RMW而形成，并且在 允许将离子束供应到一个或多个其他角度区域，其中每个角度区域中尚未获得目标剂量。 本发明可以容易地在离子束前进方向上调整患者身体的受影响部位的各个位置处的光束剂量，并且可以大大降低光束剂量在各种位置内过度或不足的错误照射的可能性 患者身体的受影响部分在离子束前进方向。

公开(公告)号：US06316776B1

公开(公告)日：2001-11-13

申请号：US09388437

申请日：1999-09-02

申请人： Kazuo Hiramoto ,  Hiroshi Akiyama ,  Koji Matsuda ,  Tetsuro Norimine ,  Masahiro Tadokoro

发明人： Kazuo Hiramoto ,  Hiroshi Akiyama ,  Koji Matsuda ,  Tetsuro Norimine ,  Masahiro Tadokoro

IPC分类号： H05H900

CPC分类号： A61N5/1042 ,  A61N5/1049 ,  A61N2005/1087 ,  A61N2005/1095

摘要： A method of irradiation with a charged particle beam and an irradiation apparatus wherein the charged particle beam supplied from an accelerator and extracted from the irradiation apparatus. The irradiation apparatus includes an electromagnet for scanning with the charged particle beam. The method includes the steps of stopping the extraction of the charged particle beam from the irradiation apparatus, changing an irradiation point of the charged particle beam by controlling the electromagnet under a condition when the extraction is stopped, and resuming the extraction of the charged particle beam from the irradiation apparatus after changing the irradiation point.

摘要翻译： 一种带电粒子束照射的方法和照射装置，其中从加速器提供并从照射装置中提取的带电粒子束。 照射装置包括用于用带电粒子束扫描的电磁体。 该方法包括以下步骤：停止从照射装置提取带电粒子束，通过在提取停止的条件下控制电磁体来改变带电粒子束的照射点，并恢复提取带电粒子束 改变照射点后从照射装置。

公开(公告)号：US20090283702A1

公开(公告)日：2009-11-19

申请号：US12129145

申请日：2008-05-29

申请人： Masumi Umezawa ,  Kazuo Hiramoto ,  Koji Matsuda

发明人： Masumi Umezawa ,  Kazuo Hiramoto ,  Koji Matsuda

IPC分类号： A61N5/00

CPC分类号： A61N5/10 ,  A61N2005/1074 ,  A61N2005/1087 ,  G21K1/043 ,  H05H7/10

摘要： A charged particle beam extraction system and method capable of shortening the irradiation time and increasing the number of patients treatable per unit time. The charged particle beam extraction system comprises a synchrotron for cyclically performing patterned operation including four steps of introducing, accelerating, extracting and decelerating an ion beam, an on/off switch for opening or closing connection between an RF knockout electrode and an RF power supply for applying RF power to the RF knockout electrode, and a timing controller for controlling on/off-timing of the on/off switch such that when extraction of the ion beam is stopped at least once during the extraction step of the synchrotron, an amount of the ion beam extracted from the synchrotron in one cycle is held substantially at a setting value.

摘要翻译： 一种带电粒子束提取系统和方法，其能够缩短照射时间并增加每单位时间可治疗的患者数量。 带电粒子束提取系统包括用于循环执行图案化操作的同步加速器，其包括引入，加速，提取和减速离子束的四个步骤，用于打开或关闭RF击穿电极和RF电源之间的连接的开/关开关， 将RF功率施加到RF击穿电极，以及定时控制器，用于控制开/关开关的接通/断开定时，使得当在同步加速器的提取步骤期间离子束的提取停止至少一次时， 在一个周期内从同步加速器提取的离子束基本保持在设定值。

公开(公告)号：US07394082B2

公开(公告)日：2008-07-01

申请号：US11414204

申请日：2006-05-01

申请人： Hisataka Fujimaki ,  Koji Matsuda ,  Hiroshi Akiyama ,  Masaki Yanagisawa ,  Alfred R. Smith ,  Kazuo Hiramoto

发明人： Hisataka Fujimaki ,  Koji Matsuda ,  Hiroshi Akiyama ,  Masaki Yanagisawa ,  Alfred R. Smith ,  Kazuo Hiramoto

IPC分类号： A61N5/00

CPC分类号： A61N5/1048 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K1/10 ,  G21K5/04

摘要： The invention is intended to confirm whether the SOBP (spread-out Bragg peak) width is a desired value in real time during beam irradiation, and to improve safety in treatment. Ion beam delivery equipment comprises a beam generator including a synchrotron, an RMW (range modulation wheel) device for forming an SOBP width of an ion beam extracted from the beam generator, a beam delivery nozzle including a reference dose monitor and a main dose monitor which are installed respectively upstream and downstream of the RMW device in the direction of travel of the ion beam, and an SOBP width computing unit for computing the SOBP width of the ion beam, which is formed by the RMW device, based on values detected by both the reference dose monitor and the main dose monitor.

摘要翻译： 本发明旨在确认在光束照射期间SOBP（展​​开布拉格峰）宽度是否是实时的期望值，并且提高了处理中的安全性。 离子束输送设备包括一个光束发生器，它包括同步加速器，用于形成从光束发生器提取的离子束的SOBP宽度的RMW（范围调制轮）装置，包括参考剂量监测器和主剂量监测器 分别安装在RMW装置的上游和下游沿着离子束行进的方向;以及SOBP宽度计算单元，用于根据由两个检测到的值计算由RMW装置形成的离子束的SOBP宽度 参考剂量监测仪和主剂量监测仪。