公开(公告)号：US07514589B2

公开(公告)日：2009-04-07

申请号：US11794817

申请日：2005-12-28

申请人： Koji Midorikawa ,  Hiroshi Takahoso ,  Junichi Yoshida ,  Seiji Suga

发明人： Koji Midorikawa ,  Hiroshi Takahoso ,  Junichi Yoshida ,  Seiji Suga

IPC分类号： C07C17/152

CPC分类号： C07B39/00 ,  C07C17/12 ,  C07C25/18 ,  C07C25/22 ,  C07C41/22 ,  C07C2602/18 ,  C07C25/02 ,  C07C43/225

摘要： The present invention is directed to provide a means, which enables production of a product superior in color tone in high yield by using an easy-to-handle and highly safe technique, in a method for producing an aromatic iodide. The present invention relates to a method for producing an aromatic iodide, characterized in that an aromatic compound and an active iodinating agent are fed into a flow reactor equipped with a high-speed mixer and hydrogen atom on the aromatic ring of said aromatic compound is continuously substituted by iodine atom.

摘要翻译： 本发明旨在提供一种在芳香族碘化物的制造方法中，通过使用易于操作和高度安全的技术，能够以高收率生产色调优异的手段。 本发明涉及一种芳族碘化物的制造方法，其特征在于，在配置有高速混合器的流动反应器中将芳香族化合物和活性碘化剂进料到所述芳香族化合物的芳香环上的氢原子连续地 被碘原子取代。

公开(公告)号：US20080146853A1

公开(公告)日：2008-06-19

申请号：US11794817

申请日：2005-12-28

申请人： Koji Midorikawa ,  Hiroshi Takahoso ,  Junichi Yoshida ,  Seiji Suga

发明人： Koji Midorikawa ,  Hiroshi Takahoso ,  Junichi Yoshida ,  Seiji Suga

IPC分类号： C07C17/152

CPC分类号： C07B39/00 ,  C07C17/12 ,  C07C25/18 ,  C07C25/22 ,  C07C41/22 ,  C07C2602/18 ,  C07C25/02 ,  C07C43/225

摘要： The present invention is directed to provide a means, which enables production of a product superior in color tone in high yield by using an easy-to-handle and highly safe technique, in a method for producing an aromatic iodide. The present invention relates to a method for producing an aromatic iodide, characterized in that an aromatic compound and an active iodinating agent are fed into a flow reactor equipped with a high-speed mixer and hydrogen atom on the aromatic ring of said aromatic compound is continuously substituted by iodine atom.

摘要翻译： 本发明旨在提供一种在芳香族碘化物的制造方法中，通过使用易于操作和高度安全的技术，能够以高收率生产色调优异的手段。 本发明涉及一种芳族碘化物的制造方法，其特征在于，在配置有高速混合器的流动反应器中将芳香族化合物和活性碘化剂进料到所述芳香族化合物的芳香环上的氢原子连续地 被碘原子取代。

公开(公告)号：US20100105969A1

公开(公告)日：2010-04-29

申请号：US12530274

申请日：2008-03-07

申请人： Junichi Yoshida ,  Seiji Suga ,  Kazuhide Kataoka ,  Koji Midorikawa ,  Yuji Hagiwara

发明人： Junichi Yoshida ,  Seiji Suga ,  Kazuhide Kataoka ,  Koji Midorikawa ,  Yuji Hagiwara

IPC分类号： C07C17/02 ,  C25B1/24

CPC分类号： C07C17/02 ,  C07B39/00 ,  C07C17/12 ,  C07C37/62 ,  C07C41/22 ,  C07C209/74 ,  C07C253/30 ,  C25B1/24 ,  C25B3/06 ,  C07C25/18 ,  C07C25/22 ,  C07C211/52 ,  C07C255/50 ,  C07C39/27 ,  C07C43/225

摘要： A method of the present invention, for producing an iodizing agent, includes the step of electrolyzing iodine molecules in a solution by using an acid as a supporting electrolyte. This realizes (i) a method of producing an iodine cation suitable for use as an iodizing agent that does not require a sophisticated separation operation after iodizing reaction is completed, and (ii) an electrolyte used in the method. Further, a method of the present invention, for producing an aromatic iodine compound, includes the step of causing an iodizing agent, and an aromatic compound whose nucleus has one or more substituent groups and two or more hydrogen atoms, to react with each other under the presence of a certain ether compound. This realizes such a method of producing an aromatic iodine compound that position selectivity in iodizing reaction of an aromatic compound is improved.

摘要翻译： 本发明的制备碘化剂的方法包括通过使用酸作为支持电解质在溶液中电解碘分子的步骤。 这实现了（i）生产适合用作碘化剂的碘阳离子的方法，其在碘化反应完成后不需要复杂的分离操作，和（ii）该方法中使用的电解质。 此外，本发明的芳香族碘化合物的制造方法包括使碘化剂和其中具有一个以上取代基和两个以上氢原子的芳香族化合物在其下反应的工序 存在某种醚化合物。 这实现了提高芳族化合物的碘化反应中选择性的芳香族碘化合物的制造方法。

公开(公告)号：US08383868B2

公开(公告)日：2013-02-26

申请号：US12530274

申请日：2008-03-07

申请人： Junichi Yoshida ,  Seiji Suga ,  Kazuhide Kataoka ,  Koji Midorikawa ,  Yuji Hagiwara

发明人： Junichi Yoshida ,  Seiji Suga ,  Kazuhide Kataoka ,  Koji Midorikawa ,  Yuji Hagiwara

IPC分类号： C07C17/00

CPC分类号： C07C17/02 ,  C07B39/00 ,  C07C17/12 ,  C07C37/62 ,  C07C41/22 ,  C07C209/74 ,  C07C253/30 ,  C25B1/24 ,  C25B3/06 ,  C07C25/18 ,  C07C25/22 ,  C07C211/52 ,  C07C255/50 ,  C07C39/27 ,  C07C43/225

摘要： A method of the present invention, for producing an iodizing agent, includes the step of electrolyzing iodine molecules in a solution by using an acid as a supporting electrolyte. This realizes (i) a method of producing an iodine cation suitable for use as an iodizing agent that does not require a sophisticated separation operation after iodizing reaction is completed, and (ii) an electrolyte used in the method. Further, a method of the present invention, for producing an aromatic iodine compound, includes the step of causing an iodizing agent, and an aromatic compound whose nucleus has one or more substituent groups and two or more hydrogen atoms, to react with each other under the presence of a certain ether compound. This realizes such a method of producing an aromatic iodine compound that position selectivity in iodizing reaction of an aromatic compound is improved.

摘要翻译： 本发明的制备碘化剂的方法包括通过使用酸作为支持电解质在溶液中电解碘分子的步骤。 这实现了（i）生产适合用作碘化剂的碘阳离子的方法，其在碘化反应完成后不需要复杂的分离操作，和（ii）该方法中使用的电解质。 此外，本发明的芳香族碘化合物的制造方法包括使碘化剂和其中具有一个以上取代基和两个以上氢原子的芳香族化合物在其下反应的工序 存在某种醚化合物。 这实现了提高芳族化合物的碘化反应中选择性的芳香族碘化合物的制造方法。

公开(公告)号：US5179221A

公开(公告)日：1993-01-12

申请号：US727447

申请日：1991-07-09

申请人： Hiroshi Takahoso ,  Norio Takahashi ,  Koji Midorikawa ,  Toshiyasu Sato

发明人： Hiroshi Takahoso ,  Norio Takahashi ,  Koji Midorikawa ,  Toshiyasu Sato

IPC分类号： B01J31/18 ,  C07B61/00 ,  C07C253/10 ,  C07C255/46

CPC分类号： C07C253/10 ,  C07C2101/14

摘要： A method for the production of 3-cyano-3,5,5-trimethyl cyclohexanone by the reaction of isophorone with hydrogen cyanide in the presence of a quaternary ammonium salt or quaternary phosphonium salt and a basic compound as a catalyst in the form dissolved or dispersed in water or in the absence of water, which method comprises effecting said reaction by using said quaternary ammonium salt or quaternary phosphonium salt in an amount in the range of from 0.001 to 0.1 mol per mol of isophorone and said basic compound and in an amount in the range of from 0.5 to 3.0 mols per mol of said quaternary ammonium salt or quaternary phosphonium salt and, when water is used, using water in an amount in the range of 0.1 to 25% by weight based on the amount of isophorone and introducing hydrogen cyanidehydrocyanic acid at a ratio in the range of from 0.6 to 1.0 mol per mol of isophorone at a temperature in the range of from 90.degree. to 140.degree. C.

公开(公告)号：US08263796B2

公开(公告)日：2012-09-11

申请号：US12734255

申请日：2008-10-21

申请人： Naoki Fujiwara ,  Kazuya Nakagawa ,  Yuichiro Kinoshita ,  Koji Midorikawa

发明人： Naoki Fujiwara ,  Kazuya Nakagawa ,  Yuichiro Kinoshita ,  Koji Midorikawa

IPC分类号： C07C253/30 ,  C07C69/003

CPC分类号： C07C253/00 ,  C07C67/22 ,  C07C69/675 ,  C07C255/16 ,  C07C255/36

摘要： A process according to the present invention for producing a cyanohydrin compound is a process for producing a cyanohydrin compound by performing a reaction between a carbonyl compound such as an aldehyde compound and hydrogen cyanide in the presence of a catalyst, a content of the carbonyl compound in a reaction system being not more than 50 mol % with respect to the cyanohydrin compound. Thus provided is a process for producing a cyanohydrin compound in good yield from an aldehyde compound and hydrogen cyanide.

摘要翻译： 根据本发明的用于制备氰醇化合物的方法是通过在催化剂存在下，通过在醛化合物和氰化氢等羰基化合物之间进行反应来制备氰腈化合物的方法，羰基化合物的含量 反应体系相对于氰醇化合物为50摩尔％以下。 因此提供了由醛化合物和氰化氢以良好的产率制备羟腈化合物的方法。

公开(公告)号：US08471053B2

公开(公告)日：2013-06-25

申请号：US12734258

申请日：2008-10-21

申请人： Yuichiro Kinoshita ,  Naoki Fujiwara ,  Kazuya Nakagawa ,  Koji Midorikawa

发明人： Yuichiro Kinoshita ,  Naoki Fujiwara ,  Kazuya Nakagawa ,  Koji Midorikawa

IPC分类号： C07C253/08

CPC分类号： C07C253/00 ,  C07C67/22 ,  C07C69/675 ,  C07C255/16 ,  C07C255/36

摘要： A process according to the present invention for producing a cyanohydrin compound flow-reacts a carbonyl compound with hydrogen cyanide in the presence of a catalyst, and can therefore reduce the residence time. This makes it possible to reduce the period of time over which the resulting cyanohydrin compound is exposed to an unreacted portion of the carbonyl compound. As a result, the resulting cyanohydrin compound can be prevented from reacting with the unreacted portion. This makes it possible to produce the cyanohydrin compound in good yield. That is, the process according to the present invention for producing a cyanohydrin compound produces a cyanohydrin compound in good yield from a carbonyl compound and hydrogen cyanide.

摘要翻译： 根据本发明的用于生产氰醇化合物的方法在催化剂存在下与氰化氢流动反应，因此可以减少停留时间。 这使得可以减少所得羟腈化合物暴露于羰基化合物的未反应部分的时间。 结果，可以防止所得羟腈化合物与未反应部分反应。 这使得可以以良好的产率生产羟腈化合物。 也就是说，根据本发明的用于制备羟腈化合物的方法由羰基化合物和氰化氢以良好的产率产生羟腈化合物。

公开(公告)号：US20100261929A1

公开(公告)日：2010-10-14

申请号：US12734258

申请日：2008-10-21

申请人： Yuichiro Kinoshita ,  Naoki Fujiwara ,  Kazuya Nakagawa ,  Koji Midorikawa

发明人： Yuichiro Kinoshita ,  Naoki Fujiwara ,  Kazuya Nakagawa ,  Koji Midorikawa

IPC分类号： C07C253/30 ,  C07C67/00 ,  B01J8/02

CPC分类号： C07C253/00 ,  C07C67/22 ,  C07C69/675 ,  C07C255/16 ,  C07C255/36

摘要： A process according to the present invention for producing a cyanohydrin compound flow-reacts a carbonyl compound with hydrogen cyanide in the presence of a catalyst, and can therefore reduce the residence time. This makes it possible to reduce the period of time over which the resulting cyanohydrin compound is exposed to an unreacted portion of the carbonyl compound. As a result, the resulting cyanohydrin compound can be prevented from reacting with the unreacted portion. This makes it possible to produce the cyanohydrin compound in good yield. That is, the process according to the present invention for producing a cyanohydrin compound produces a cyanohydrin compound in good yield from a carbonyl compound and hydrogen cyanide.

摘要翻译： 根据本发明的用于生产氰醇化合物的方法在催化剂存在下与氰化氢流动反应，因此可以减少停留时间。 这使得可以减少所得羟腈化合物暴露于羰基化合物的未反应部分的时间。 结果，可以防止所得羟腈化合物与未反应部分反应。 这使得可以以良好的产率生产羟腈化合物。 也就是说，根据本发明的用于制备羟腈化合物的方法由羰基化合物和氰化氢以良好的产率产生羟腈化合物。

公开(公告)号：US20100256409A1

公开(公告)日：2010-10-07

申请号：US12734255

申请日：2008-10-21

申请人： Naoki Fujiwara ,  Kazuya Nakagawa ,  Yuichiro Kinoshita ,  Koji Midorikawa

发明人： Naoki Fujiwara ,  Kazuya Nakagawa ,  Yuichiro Kinoshita ,  Koji Midorikawa

IPC分类号： C07C253/30 ,  C07C69/003

CPC分类号： C07C253/00 ,  C07C67/22 ,  C07C69/675 ,  C07C255/16 ,  C07C255/36

摘要： A process according to the present invention for producing a cyanohydrin compound is a process for producing a cyanohydrin compound by performing a reaction between a carbonyl compound such as an aldehyde compound and hydrogen cyanide in the presence of a catalyst, a content of the carbonyl compound in a reaction system being not more than 50 mol % with respect to the cyanohydrin compound. Thus provided is a process for producing a cyanohydrin compound in good yield from an aldehyde compound and hydrogen cyanide.

摘要翻译： 根据本发明的用于制备氰醇化合物的方法是通过在催化剂存在下，通过在醛化合物和氰化氢等羰基化合物之间进行反应来制备氰腈化合物的方法，羰基化合物的含量 反应体系相对于氰醇化合物为50摩尔％以下。 因此提供了由醛化合物和氰化氢以良好的产率制备羟腈化合物的方法。