公开(公告)号：US20100210028A1

公开(公告)日：2010-08-19

申请号：US12668266

申请日：2008-09-25

申请人： Koji Miyoshi ,  Masahiro Aga ,  Takahiko Tanida ,  Ryosuke Yamada ,  Hideyuki Kurokawa ,  Yoko Matsuda

发明人： Koji Miyoshi ,  Masahiro Aga ,  Takahiko Tanida ,  Ryosuke Yamada ,  Hideyuki Kurokawa ,  Yoko Matsuda

IPC分类号： G01N21/00 ,  G01N33/00

CPC分类号： G01N21/78 ,  G01N21/8483

摘要： In a biosensor for measuring the concentration of an object to be analyzed by optical signal detection, when a liquid sample is supplied to a supply part (12), the liquid sample is developed in a development part (13), and color development takes place in a reaction part (14) depending upon the concentration of the object to be analyzed. The absorbance of the reaction part (14) is read. In this case, the amount of the liquid sample supplied into the supply part (12) can be measured by reading the development speed.

摘要翻译： 在用于通过光信号检测来测量待分析物体的浓度的生物传感器中，当液体样品被供应到供应部分（12）时，液体样品在显影部分（13）中显影，并且发生颜色显现 在反应部分（14）中，取决于待分析物体的浓度。 读取反应部分（14）的吸光度。 在这种情况下，可以通过读取显影速度来测量供应部件（12）中供应的液体样品的量。

公开(公告)号：US08447084B2

公开(公告)日：2013-05-21

申请号：US12740447

申请日：2008-10-14

申请人： Masahiro Aga ,  Koji Miyoshi ,  Mie Takahashi ,  Hideyuki Kurokawa ,  Takahiko Tanida ,  Ryosuke Yamada ,  Yoko Matsuda

发明人： Masahiro Aga ,  Koji Miyoshi ,  Mie Takahashi ,  Hideyuki Kurokawa ,  Takahiko Tanida ,  Ryosuke Yamada ,  Yoko Matsuda

IPC分类号： G06K9/00 ,  G01N21/84 ,  G01N33/543

CPC分类号： G01N21/8483 ,  G01N30/95 ,  G01N33/54386 ,  G01N33/558 ,  G01N2201/1242

摘要： By measuring a luminance difference between predetermined two points or a luminance variation in a predetermined region in a state in which a liquid sample is developed in a chromatography specimen 1, and comparing the luminance difference or the luminance variation with a preset reference value, it is possible to automatically detect degradation such as a decrease in hydrophilicity in the lower portion of a liquid-impermeable sheet material 8 during a chromatography inspection, thereby enabling an accurate inspection.

摘要翻译： 通过在色谱试样1中测定液体样品的显色状态，将亮度差或亮度变化与预先设定的基准值进行比较，测定预定的两点之间的亮度差或者在规定区域的亮度变化， 可以自动检测色谱检查时的不透液性片材8的下部的亲水性降低的劣化，能够进行准确的检查。

公开(公告)号：US20100260411A1

公开(公告)日：2010-10-14

申请号：US12740447

申请日：2008-10-14

申请人： Masahiro Aga ,  Koji Miyoshi ,  Mie Takahashi ,  Hideyuki Kurokawa ,  Takahiko Tanida ,  Ryosuke Yamada ,  Yoko Matsuda

发明人： Masahiro Aga ,  Koji Miyoshi ,  Mie Takahashi ,  Hideyuki Kurokawa ,  Takahiko Tanida ,  Ryosuke Yamada ,  Yoko Matsuda

IPC分类号： G06K9/00

CPC分类号： G01N21/8483 ,  G01N30/95 ,  G01N33/54386 ,  G01N33/558 ,  G01N2201/1242

摘要： By measuring a luminance difference between predetermined two points or a luminance variation in a predetermined region in a state in which a liquid sample is developed in a chromatography specimen 1, and comparing the luminance difference or the luminance variation with a preset reference value, it is possible to automatically detect degradation such as a decrease in hydrophilicity in the lower portion of a liquid-impermeable sheet material 8 during a chromatography inspection, thereby enabling an accurate inspection.

摘要翻译： 通过在色谱试样1中测定液体样品的显色状态，将亮度差或亮度变化与预先设定的基准值进行比较，测定预定的两点之间的亮度差或者在规定区域的亮度变化， 可以自动检测色谱检查时的不透液性片材8的下部的亲水性降低的劣化，能够进行准确的检查。

公开(公告)号：US20100273271A1

公开(公告)日：2010-10-28

申请号：US12810391

申请日：2008-12-04

申请人： Takahiko Tanida ,  Koji Miyoshi ,  Masahiro Aga ,  Ryosuke Yamada ,  Hideyuki Kurokawa ,  Yoko Matsuda ,  Mie Takahashi

发明人： Takahiko Tanida ,  Koji Miyoshi ,  Masahiro Aga ,  Ryosuke Yamada ,  Hideyuki Kurokawa ,  Yoko Matsuda ,  Mie Takahashi

IPC分类号： G01N21/00 ,  G06K9/00

CPC分类号： G01N21/8483

摘要： A solution measurement method in which a specimen X stored in a capillary 8 is developed from the capillary 8 to the development layer of a test piece, and the amount of a substance to be measured in the specimen X is calculated by measuring the optical property of a predetermined portion to be measured, the method including: measuring the portion to be measured, in response to a reduction of the specimen X in the capillary 8 to a predetermined amount or less; and calculating the amount of the substance to be measured in the specimen X, based on the measured value. According to this method, it, is possible to detect that a certain amount of the specimen X has flown from the capillary 8 to the portion to be measured on the development layer.

摘要翻译： 存储在毛细管8中的试样X从毛细管8显影到试验片的显影层的溶液测定方法，通过测定试样X的被测定物质的光学性质， 所述方法包括：响应于毛细管8中的样本X的减少到预定量或更少的量来测量待测量部分; 并根据测定值计算样品X中待测物质的量。 根据这种方法，可以检测出一定量的试样X从显影层上的毛细管8流向待测量部分。

公开(公告)号：US20110053291A1

公开(公告)日：2011-03-03

申请号：US12863070

申请日：2009-01-09

申请人： Yoko Matsuda ,  Mie Takahashi ,  Masahiro Aga ,  Hideyuki Kurokawa ,  Takahiko Tanida ,  Ryosuke Yamada

发明人： Yoko Matsuda ,  Mie Takahashi ,  Masahiro Aga ,  Hideyuki Kurokawa ,  Takahiko Tanida ,  Ryosuke Yamada

IPC分类号： G01N33/558

CPC分类号： G01N33/558 ,  G01N33/54366 ,  G01N33/54393 ,  Y10T436/25

摘要： Disclosed is a method for analyzing a sample solution, including introducing a sample solution 50 through a sample introduction part 6 and developing the sample solution 50 to a developing layer 2 through a capillary phenomenon to analyze an analyte contained in the sample solution 50, the sample introduction part 6 being provided on one side of a test strip 100 and the developing layer 2 being provided on the other side of the test strip 100, wherein the test strip 100 is disposed in such a development posture that the downstream region of the developing layer faces downward during the development. By this method, the developing rate is less susceptible to the viscosity of the sample solution 50 and thus has a small difference even among sample solutions 50 differing in viscosity. As a result, the analytical accuracy and reliability can be improved.

摘要翻译： 公开了一种用于分析样品溶液的方法，包括通过样品引入部分6引入样品溶液50并通过毛细管现象将样品溶液50显影到显影层2，以分析样品溶液50中包含的分析物，样品 导入部6设置在测试条100的一侧，显影层2设置在测试条100的另一侧，其中测试条100以显影层的下游区域的显影姿态设置 在发展过程中面临下降。 通过该方法，显影速率对样品溶液50的粘度较不敏感，因此即使在粘度不同的样品溶液50中也具有小的差异。 因此，可以提高分析精度和可靠性。

公开(公告)号：US08481330B2

公开(公告)日：2013-07-09

申请号：US12863070

申请日：2009-01-09

申请人： Yoko Matsuda ,  Mie Takahashi ,  Masahiro Aga ,  Hideyuki Kurokawa ,  Takahiko Tanida ,  Ryosuke Yamada

发明人： Yoko Matsuda ,  Mie Takahashi ,  Masahiro Aga ,  Hideyuki Kurokawa ,  Takahiko Tanida ,  Ryosuke Yamada

IPC分类号： G01N21/03

CPC分类号： G01N33/558 ,  G01N33/54366 ,  G01N33/54393 ,  Y10T436/25

摘要： Disclosed is a method for analyzing a sample solution, including introducing a sample solution 50 through a sample introduction part 6 and developing the sample solution 50 to a developing layer 2 through a capillary phenomenon to analyze an analyte contained in the sample solution 50, the sample introduction part 6 being provided on one side of a test strip 100 and the developing layer 2 being provided on the other side of the test strip 100, wherein the test strip 100 is disposed in such a development posture that the downstream region of the developing layer faces downward during the development. By this method, the developing rate is less susceptible to the viscosity of the sample solution 50 and thus has a small difference even among sample solutions 50 differing in viscosity. As a result, the analytical accuracy and reliability can be improved.

摘要翻译： 公开了一种用于分析样品溶液的方法，包括通过样品引入部分6引入样品溶液50并通过毛细管现象将样品溶液50显影到显影层2，以分析样品溶液50中包含的分析物，样品 导入部6设置在测试条100的一侧，显影层2设置在测试条100的另一侧，其中测试条100以显影层的下游区域的显影姿态设置 在发展过程中面临下降。 通过该方法，显影速率对样品溶液50的粘度较不敏感，因此即使在粘度不同的样品溶液50中也具有小的差异。 因此，可以提高分析精度和可靠性。

公开(公告)号：US08345249B2

公开(公告)日：2013-01-01

申请号：US12935156

申请日：2009-03-26

申请人： Hideyuki Kurokawa ,  Koji Miyoshi ,  Masahiro Aga ,  Kenji Murakami ,  Takahiko Tanida ,  Ryosuke Yamada

发明人： Hideyuki Kurokawa ,  Koji Miyoshi ,  Masahiro Aga ,  Kenji Murakami ,  Takahiko Tanida ,  Ryosuke Yamada

IPC分类号： G01N33/48 ,  G01N21/00

CPC分类号： G01N30/92 ,  G01N21/8483 ,  G01N33/558

摘要： Provided is a liquid sample analyzing method for analyzing an analyte in a liquid sample by using a test piece (1) on which overflow blocking lines (7) are formed to prevent the liquid sample from flowing to the outside from a passage region (3a) of an extended layer (3). In a state in which the liquid sample is not extended in the passage region (3a) of the extended region (3), the test piece (1) is measured so as to cross the passage region (3a) of the extended layer (3) and the overflow blocking lines (7). Thus in a state in which a difference in brightness is large between the passage region (3a) of the extended region (3) and the overflow blocking lines (7), it is possible to properly recognize the boundary portions between the passage region (3a) of the extended region (3) and the overflow blocking lines (7).

摘要翻译： 提供一种液体样品分析方法，用于通过使用其上形成有溢流阻挡线（7）的试验片（1）来分析液体样品中的分析物，以防止液体样品从通道区域（3a）流到外部， 的扩展层（3）。 在液体样品未在延伸区域（3）的通道区域（3a）中延伸的状态下，测试试件（1），以便与延伸层（3）的通过区域（3a）交叉 ）和溢流阻塞线（7）。 因此，在延伸区域（3）的通过区域（3a）和溢流阻塞线（7）之间的亮度差大的状态下，可以适当地识别通过区域（3a）之间的边界部分 ）和溢出阻塞线（7）。

公开(公告)号：US20100290051A1

公开(公告)日：2010-11-18

申请号：US12864439

申请日：2009-01-22

申请人： Ryosuke Yamada ,  Masahiro Aga ,  Koji Miyoshi ,  Kenji Murakami ,  Hideyuki Kurokawa ,  Takahiko Tanida

发明人： Ryosuke Yamada ,  Masahiro Aga ,  Koji Miyoshi ,  Kenji Murakami ,  Hideyuki Kurokawa ,  Takahiko Tanida

IPC分类号： G01N21/55 ,  G01D18/00 ,  G01N21/27

CPC分类号： G01N21/253 ,  G01N21/274 ,  G01N21/8483

摘要： Provided is a device in which light from a sample 7 fixed in a test piece 1 is captured by an image sensor 5 through an optical system made up of a lens 3, a diaphragm 4, and so on and concentration information is obtained, wherein a wide-band light source 12 for illuminating the test piece 1 is combined with an optical filter 13 for optionally selecting a wavelength of the light captured by the image sensor. Thus it is possible to reduce a measurement error caused by a change of the light quantity distribution of the light source 12.

摘要翻译： 提供了一种装置，其中固定在测试片1中的样品7的光通过由透镜3，隔膜4等构成的光学系统由图像传感器5捕获，并且获得浓度信息，其中 用于照射测试件1的宽带光源12与用于可选地选择由图像传感器捕获的光的波长的滤光器13组合。 因此，可以减少由光源12的光量分布的变化引起的测量误差。

公开(公告)号：US08310678B2

公开(公告)日：2012-11-13

申请号：US12864439

申请日：2009-01-22

申请人： Ryosuke Yamada ,  Masahiro Aga ,  Koji Miyoshi ,  Kenji Murakami ,  Hideyuki Kurokawa ,  Takahiko Tanida

发明人： Ryosuke Yamada ,  Masahiro Aga ,  Koji Miyoshi ,  Kenji Murakami ,  Hideyuki Kurokawa ,  Takahiko Tanida

IPC分类号： G01N21/55 ,  G01N21/47

CPC分类号： G01N21/253 ,  G01N21/274 ,  G01N21/8483

摘要： Provided is a device in which light from a sample 7 fixed in a test piece 1 is captured by an image sensor 5 through an optical system made up of a lens 3, a diaphragm 4, and so on and concentration information is obtained, wherein a wide-band light source 12 for illuminating the test piece 1 is combined with an optical filter 13 for optionally selecting a wavelength of the light captured by the image sensor. Thus it is possible to reduce a measurement error caused by a change of the light quantity distribution of the light source 12.

摘要翻译： 提供了一种装置，其中固定在测试片1中的样品7的光通过由透镜3，隔膜4等构成的光学系统由图像传感器5捕获，并且获得浓度信息，其中 用于照射测试件1的宽带光源12与用于可选地选择由图像传感器捕获的光的波长的滤光器13组合。 因此，可以减少由光源12的光量分布的变化引起的测量误差。

公开(公告)号：US20110032525A1

公开(公告)日：2011-02-10

申请号：US12935156

申请日：2009-03-26

申请人： Hideyuki Kurokawa ,  Koji Miyoshi ,  Masahiro Aga ,  Kenji Murakami ,  Takahiko Tanida ,  Ryosuke Yamada

发明人： Hideyuki Kurokawa ,  Koji Miyoshi ,  Masahiro Aga ,  Kenji Murakami ,  Takahiko Tanida ,  Ryosuke Yamada

IPC分类号： G01J3/46

CPC分类号： G01N30/92 ,  G01N21/8483 ,  G01N33/558

摘要： Provided is a liquid sample analyzing method for analyzing an analyte in a liquid sample by using a test piece (1) on which overflow blocking lines (7) are formed to prevent the liquid sample from flowing to the outside from a passage region (3a) of an extended layer (3). In a state in which the liquid sample is not extended in the passage region (3a) of the extended region (3), the test piece (1) is measured so as to cross the passage region (3a) of the extended layer (3) and the overflow blocking lines (7). Thus in a state in which a difference in brightness is large between the passage region (3a) of the extended region (3) and the overflow blocking lines (7), it is possible to properly recognize the boundary portions between the passage region (3a) of the extended region (3) and the overflow blocking lines (7).

摘要翻译： 提供一种液体样品分析方法，用于通过使用其上形成有溢流阻挡线（7）的试验片（1）来分析液体样品中的分析物，以防止液体样品从通道区域（3a）流到外部， 的扩展层（3）。 在液体样品未在延伸区域（3）的通道区域（3a）中延伸的状态下，测试试件（1），以便与延伸层（3）的通过区域（3a）交叉 ）和溢流阻塞线（7）。 因此，在延伸区域（3）的通过区域（3a）和溢流阻塞线（7）之间的亮度差大的状态下，可以适当地识别通过区域（3a）之间的边界部分 ）和溢出阻塞线（7）。