公开(公告)号：US09295667B2

公开(公告)日：2016-03-29

申请号：US14178090

申请日：2014-02-11

Applicant: Korea Basic Science Institute

Inventor： Gun-Hwa Kim ,  Soohyun Kim ,  Jong-Soon Choi ,  Seung Il Kim ,  Edmond Changkyun Park

IPC: A61K31/41 ,  A61K31/415 ,  A61K31/20 ,  A61K31/18 ,  A61K31/15 ,  A61K31/4192 ,  A61K31/155 ,  A61K31/201 ,  A61K31/4174

CPC classification number: A61K31/4192 ,  A61K31/15 ,  A61K31/155 ,  A61K31/18 ,  A61K31/201 ,  A61K31/4174

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating diabetes or fatty liver, and more specifically relates to a pharmaceutical composition for preventing or treating diabetes or fatty liver containing a CYP4A (cytochrome P450A) inhibitor as an active ingredient. According to the present invention, the CYP4A inhibitor suppresses endoplasmic reticulum stress, reduces the blood insulin concentration and suppresses apoptosis of liver cells, and hence exhibits effects in preventing or treating diabetes or fatty liver.

Abstract translation: 本发明涉及用于预防或治疗糖尿病或脂肪肝的药物组合物，更具体地涉及含有CYP4A（细胞色素P450A）抑制剂作为活性成分的糖尿病或脂肪肝的预防或治疗药物组合物。 根据本发明，CYP4A抑制剂抑制内质网应激，降低血胰岛素浓度，抑制肝细胞凋亡，因此具有预防或治疗糖尿病或脂肪肝的作用。

公开(公告)号：US20140275198A1

公开(公告)日：2014-09-18

申请号：US14178090

申请日：2014-02-11

Applicant: Korea Basic Science Institute

Inventor： Gun-Hwa Kim ,  Soohyun Kim ,  Jong-Soon Choi ,  Seung II Kim ,  Edmond Changkyun Park

IPC: A61K31/4192 ,  A61K31/4174 ,  A61K31/201 ,  A61K31/15 ,  A61K31/18

CPC classification number: A61K31/4192 ,  A61K31/15 ,  A61K31/155 ,  A61K31/18 ,  A61K31/201 ,  A61K31/4174

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating diabetes or fatty liver, and more specifically relates to a pharmaceutical composition for preventing or treating diabetes or fatty liver containing a CYP4A (cytochrome P450A) inhibitor as an active ingredient. According to the present invention, the CYP4A inhibitor suppresses endoplasmic reticulum stress, reduces the blood insulin concentration and suppresses apoptosis of liver cells, and hence exhibits effects in preventing or treating diabetes or fatty liver.

Abstract translation: 本发明涉及用于预防或治疗糖尿病或脂肪肝的药物组合物，更具体地涉及含有CYP4A（细胞色素P450A）抑制剂作为活性成分的糖尿病或脂肪肝的预防或治疗药物组合物。 根据本发明，CYP4A抑制剂抑制内质网应激，降低血胰岛素浓度，抑制肝细胞凋亡，因此具有预防或治疗糖尿病或脂肪肝的作用。

公开(公告)号：US10266898B2

公开(公告)日：2019-04-23

申请号：US14600419

申请日：2015-01-20

Applicant: Korea Basic Science Institute

Inventor： Gun-Hwa Kim ,  Giwon Kim ,  Soohyun Kim ,  Seung II Kim ,  Edmond Changkyun Park

IPC: C12Q1/68 ,  C12P19/34 ,  C12Q1/6886

Abstract: The present invention relates to a recurring glioblastoma multiforme marker miRNA for diagnosing recurring glioblastoma multiforme, and more specifically, to a composition for screening the miRNA marker, which is specific to the recurring glioblastoma multiforme and comprises an agent for detecting the presence of the marker, a kit, and to a method for diagnosing the recurring glioblastoma multiforme using same. The method for diagnosing the recurring glioblastoma multiforme by using the recurring glioblastoma multiforme marker miRNA, according to the present invention, provides glioblastoma markers, which can diagnose the occurrence of the recurring glioblastoma multiforme, thereby providing useful material for managing treatment and prognosis of the recurring glioblastoma multiforme. In addition, the diagnosis markers for the recurring glioblastoma multiforme can be used for development and research of an anticancer agent specific to the recurring glioblastoma multiforme.

公开(公告)号：US20150232946A1

公开(公告)日：2015-08-20

申请号：US14600419

申请日：2015-01-20

Applicant: Korea Basic Science Institute

Inventor： Gun-Hwa Kim ,  Giwon Kim ,  Soohyun Kim ,  Seung II Kim ,  Edmond Changkyun Park

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178

Abstract: The present invention relates to a recurring glioblastoma multiforme marker miRNA for diagnosing recurring glioblastoma multiforme, and more specifically, to a composition for screening the miRNA marker, which is specific to the recurring glioblastoma multiforme and comprises an agent for detecting the presence of the marker, a kit, and to a method for diagnosing the recurring glioblastoma multiforme using same. The method for diagnosing the recurring glioblastoma multiforme by using the recurring glioblastoma multiforme marker miRNA, according to the present invention, provides glioblastoma markers, which can diagnose the occurrence of the recurring glioblastoma multiforme, thereby providing useful material for managing treatment and prognosis of the recurring glioblastoma multiforme. In addition, the diagnosis markers for the recurring glioblastoma multiforme can be used for development and research of an anticancer agent specific to the recurring glioblastoma multiforme.

Abstract translation: 本发明涉及用于诊断多形性复制性成胶质细胞瘤的复发性成胶质细胞瘤多形性标志物miRNA，更具体地，涉及对多发性成胶质细胞瘤特异性的miRNA标志物的筛选用组合物，其包含用于检测标志物存在的试剂， 一种试剂盒，以及使用该方法诊断复发性多形性成胶质细胞瘤的方法。 根据本发明，通过使用复发性成胶质细胞瘤多形性标志物miRNA诊断多形性成胶质细胞瘤的方法提供了可以诊断复发性多形性成胶质细胞瘤的发生的成胶质细胞瘤标志物，从而提供用于治疗复发性成骨细胞瘤的治疗和预后的有用材料 胶质母细胞瘤多形性。 此外，复发性胶质母细胞瘤多形性的诊断标志物可用于对复发性多形性成胶质细胞瘤特异性的抗癌剂的开发和研究。