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    1,3,6-Substituted Indole Derivatives Having Inhibitory Activity for Protein Kinase
    1.
    发明申请
    1,3,6-Substituted Indole Derivatives Having Inhibitory Activity for Protein Kinase 有权
    具有蛋白激酶抑制活性的1,3,6-取代吲哚衍生物

    公开(公告)号：US20130079343A1

    公开(公告)日：2013-03-28

    申请号：US13684507

    申请日：2012-11-24

    Applicant: Korea Institute of Science and Technology

    Inventor： Tae Bo Sim ,  Young Jin Ham ,  Hwan Geun Choi

    IPC: C07D403/04 ,  C07D403/14 ,  C07D413/14 ,  C07D401/14 ,  C07D401/04

    CPC classification number: C07D403/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14

    Abstract: Disclosed are a 1,3,6-substituted indole compound having inhibitory activity for protein kinases, a pharmaceutically acceptable thereof, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth including the compound as an active ingredient.Since the novel indole compound exhibits superior inhibitory activity for various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.

    Abstract translation: 公开了对蛋白激酶具有抑制活性的1,3,6-取代的吲哚化合物，其药学上可接受的物质，以及用于预防和治疗由异常细胞生长引起的疾病的药物组合物，包括该化合物作为活性成分。 由于新型吲哚化合物对参与生长因子信号转导的各种蛋白激酶具有优异的抑制活性，因此可用作预防或治疗由异常细胞生长引起的癌症的药剂。

    1,3,6-substituted indole derivatives having inhibitory activity for protein kinase
    2.
    发明授权
    1,3,6-substituted indole derivatives having inhibitory activity for protein kinase 有权
    具有蛋白激酶抑制活性的1,3,6-取代的吲哚衍生物

    公开(公告)号：US08648089B2

    公开(公告)日：2014-02-11

    申请号：US13684507

    申请日：2012-11-24

    Applicant: Korea Institute of Science and Technology

    Inventor： Tae Bo Sim ,  Young Jin Ham ,  Hwan Geun Choi

    IPC: A01N43/54 ,  A61K31/505

    CPC classification number: C07D403/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14

    Abstract: Disclosed are a 1,3,6-substituted indole compound having inhibitory activity for protein kinases, a pharmaceutically acceptable thereof, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth including the compound as an active ingredient.Since the novel indole compound exhibits superior inhibitory activity for various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.

    Abstract translation: 公开了对蛋白激酶具有抑制活性的1,3,6-取代的吲哚化合物，其药学上可接受的物质，以及用于预防和治疗由异常细胞生长引起的疾病的药物组合物，包括该化合物作为活性成分。 由于新型吲哚化合物对参与生长因子信号转导的各种蛋白激酶具有优异的抑制活性，因此可用作预防或治疗由异常细胞生长引起的癌症的药剂。

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