公开(公告)号：US09766247B2

公开(公告)日：2017-09-19

申请号：US14513774

申请日：2014-10-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun Joo Song ,  Hyunjung Lee ,  Eunmi Ban ,  Eunice EunKyeong Kim ,  Young Sook Yoo

IPC: G01N33/50 ,  G01N33/58 ,  G01N33/68

CPC classification number: G01N33/68 ,  G01N33/502 ,  G01N2500/02

Abstract: Provided are a method of analyzing ubiquitin-proteasome activity with respect to a target polypeptide and a method of screening a ubiquitin-proteasome inhibitor. According to the provided methods, the pattern of lysis of a target polypeptide by a ubiquitin-proteasome in target cells may be quantitatively analyzed in a rapid and highly sensitive way, a ubiquitin-proteasome inhibitor may be screened in a rapid and highly sensitive way, and an anticancer agent and the activity thereof may be rapidly screened.

公开(公告)号：US08748592B1

公开(公告)日：2014-06-10

申请号：US13760271

申请日：2013-02-06

Applicant: Korea Institute of Science and Technology

Inventor： Eun Joo Song ,  Hyunjung Lee

IPC: C07H21/04 ,  A61K48/00 ,  C12N15/113

CPC classification number: C12N15/1137 ,  C12N2310/14 ,  C12Y304/00

Abstract: The present invention relates to an siRNA inhibiting expression of the OTUB1 protein and a composition for preventing or treating cancer containing same as an active ingredient. In accordance with the present invention, cancer cell growth can be remarkably inhibited by inhibiting OTUB1 expression using the siRNA of the present invention.

Abstract translation: 本发明涉及抑制OTUB1蛋白的表达的siRNA和用于预防或治疗含有其的作为活性成分的癌症的组合物。 根据本发明，通过使用本发明的siRNA抑制OTUB1表达，可以显着抑制癌细胞生长。