公开(公告)号：US20230381226A1

公开(公告)日：2023-11-30

申请号：US18322723

申请日：2023-05-24

Applicant: SHIFTBIO INC. ,  Korea Institute of Science and Technology

Inventor： In San KIM ,  Seungyoon PARK ,  Gi-Hoon NAM ,  Inkyu LEE

IPC: A61K35/12 ,  C12N15/85 ,  C12N5/00

CPC classification number: A61K35/12 ,  C12N15/85 ,  C12N5/0006 ,  C12N2800/107

Abstract: The present invention provides surface-engineered extracelluar vesicles, compositions comprising the surface-engineered extracelluar vesicles, methods for preparing the surface-engineered extracelluar vesicles, and methods for using the surface-engineered extracelluar vesicles or the compositions.

公开(公告)号：US20140288300A1

公开(公告)日：2014-09-25

申请号：US13936768

申请日：2013-07-08

Applicant: Korea Institute of Science and Technology

Inventor： Kwang Meyung KIM ,  Ick Chan KWON ,  Sang Yoon KIM ,  Ju Hee RYU ,  Eun Sung JUN ,  In San KIM

IPC: C07D499/78 ,  C07D409/14 ,  C07D498/08 ,  C07D209/62

CPC classification number: C07D499/78 ,  C07D209/62 ,  C07D409/14 ,  C07D498/08

Abstract: Disclosed is a drug-fluorophore complex for specific detection of tumor cells. Specifically, the drug-fluorophore complex includes a tumor cell-targeting drug penetrating tumor cells and non-tumor cells at different rates or levels, and a fluorescent substance chemically bonded to the tumor cell-targeting drug. The drug-fluorophore complex enables specific imaging of tumor cells only with high accuracy in a very simple manner without causing cytotoxicity.

Abstract translation: 公开了用于特异性检测肿瘤细胞的药物 - 荧光团复合物。 具体地，药物 - 荧光团复合物包括以不同速率或水平渗透肿瘤细胞和非肿瘤细胞的肿瘤细胞靶向药物和与肿瘤细胞靶向药物化学键合的荧光物质。 药物荧光团复合物能够以非常简单的方式以高精度进行肿瘤细胞的特异性成像，而不引起细胞毒性。