公开(公告)号：US20250134989A1

公开(公告)日：2025-05-01

申请号：US18931284

申请日：2024-10-30

Applicant: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION ,  Korea National Institute of Health

Inventor： Won Jong KIM ,  Hong Lyun KIM ,  So Hee PARK ,  Soo-Min KIM ,  Jung-Ah LEE ,  Eunkyung SHIN ,  You-Jin KIM ,  Hye Sook JEONG ,  Dokeun KIM

IPC: A61K39/215 ,  A61K9/51 ,  A61K39/00 ,  A61K45/06 ,  A61P31/14 ,  C12N7/00

Abstract: The present invention relates to a novel vaccine composition for coronavirus infection-19 comprising a polymer-based mRNA carrier. Specifically, the present invention provides a vaccine composition comprising an mRNA carrier using a novel polymer capable of delivering a negatively charged genetic material such as mRNA, and the vaccine composition has excellent effects of enhanced in vivo immune activity such as high antibody formation ability and increased interferon-gamma production.

公开(公告)号：US20240316180A1

公开(公告)日：2024-09-26

申请号：US18516257

申请日：2023-11-21

Applicant: Korea National Institute of Health

Inventor： Tae-young LEE ,  Seo Yeon KIM ,  Hyeran WON ,  You-Jin KIM ,  Dokeun KIM

IPC: A61K39/165 ,  A61P31/14 ,  A61P37/04 ,  C12N7/00 ,  G01N33/569

CPC classification number: A61K39/165 ,  A61P31/14 ,  A61P37/04 ,  C12N7/00 ,  G01N33/56983 ,  A61K2039/5254 ,  C12N2760/18721 ,  C12N2760/18722 ,  C12N2760/18734 ,  G01N2333/12

Abstract: The present invention relates to an attenuated mumps virus and a live vaccine comprising the same. The attenuated mumps virus vaccine of the present invention can be effectively used for additional vaccination to control the occurrence of breakthrough infection and the epidemic of mumps due to differences in genotypes of existing vaccine strains and epidemic strains and decreased immunity.