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公开(公告)号:US20050054678A1
公开(公告)日:2005-03-10
申请号:US10398485
申请日:2001-10-05
申请人: Kosuke Yasuda , Hiroshi Morimoto , Saburo Kawanami , Masataka Hikota , Takeshi Matsumoto , Kenji Arakawa
发明人: Kosuke Yasuda , Hiroshi Morimoto , Saburo Kawanami , Masataka Hikota , Takeshi Matsumoto , Kenji Arakawa
IPC分类号: A61P3/10 , A61P43/00 , C07D207/16 , C07D207/40 , C07D207/404 , C07D207/416 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D513/04 , A61K31/454 , A61K31/401 , A61K31/426 , C07D417/02 , C07D43/02
CPC分类号: C07D207/404 , A61K31/40 , A61K31/425 , A61K31/44 , A61K31/4965 , A61K31/497 , A61K31/5375 , C07D207/16 , C07D207/416 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
摘要: The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein symbols in the formula have the following meanings; A: —CH2— or —S—, B: CH or N, R1: H, a lower alkyl group, etc., X: a single bonding arm, —CO—, -Alk-CO—, —COCH2—, -Alk-O—, —O—CH2—, —SO2—, —S—, —COO—, —CON(R3)—, -Alk-CON(R3)—, —CON(R3)CH2—, —NHCH2—, etc., R3: hydrogen atom or a lower alkyl group, Alk: a lower alkylene group, and R2: (1) a cyclic group which may be substituted, (2) a substituted amino group, etc., provided that when X is —CO—, then B is N, or a pharmaceutically acceptable salt thereof.
摘要翻译: 本发明提供由式[I]表示的脂族含氮的五元环化合物:其中式中的符号具有以下含义: A:-CH 2 - 或-S-,B:CH或N,R 1:H,低级烷基等; X:单键键,-CO-,-Alk-CO-,-COCH2 - , - Alk-O-,-O-CH 2 - , - SO 2 - , - S - , - COO - , - CON(R 3) - ,-Alk-CON(R 3) (R 3)CH 2 - , - NHCH 2 - 等,R 3:氢原子或低级烷基,Alk:低级亚烷基和R 2:(1)环状基团, (2)取代氨基等,条件是当X是-CO-时,B是N,或其药学上可接受的盐。
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公开(公告)号:US20080153821A1
公开(公告)日:2008-06-26
申请号:US12000024
申请日:2007-12-07
申请人: Kosuke Yasuda , Hiroshi Morimoto , Saburo Kawanami , Masataka Hikota , Takeshi Matsumoto , Kenji Arakawa
发明人: Kosuke Yasuda , Hiroshi Morimoto , Saburo Kawanami , Masataka Hikota , Takeshi Matsumoto , Kenji Arakawa
IPC分类号: A61K31/5375 , A61P3/10 , A61K31/425 , A61K31/4965 , A61K31/44 , A61K31/497 , A61K31/40
CPC分类号: C07D207/404 , A61K31/40 , A61K31/425 , A61K31/44 , A61K31/4965 , A61K31/497 , A61K31/5375 , C07D207/16 , C07D207/416 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
摘要: The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein symbols in the formula have the following meanings; A: —CH2— or —S—, B: CH or N, R1: H, a lower alkyl group, etc., X: a single bonding arm, —CO—, -Alk-CO—, —COCH2—, -Alk-O—, —O—CH2—, —SO2—, —S—, —COO—, —CON(R3)—, -Alk-CON(R3)—, —CON(R3)CH2—, —NHCH2—, etc., R3: hydrogen atom or a lower alkyl group, Alk: a lower alkylene group, and R2: (1) a cyclic group which may be substituted, (2) a substituted amino group, etc., provided that when X is —CO—, then B is N, or a pharmaceutically acceptable salt thereof.
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公开(公告)号:US20060241146A1
公开(公告)日:2006-10-26
申请号:US11452923
申请日:2006-06-15
申请人: Kosuke Yasuda , Hiroshi Morimoto , Saburo Kawanami , Masataka Hikota , Takeshi Matsumoto , Kenji Arakawa
发明人: Kosuke Yasuda , Hiroshi Morimoto , Saburo Kawanami , Masataka Hikota , Takeshi Matsumoto , Kenji Arakawa
IPC分类号: A61K31/454 , A61K31/426 , A61K31/401 , C07D417/02 , C07D403/02
CPC分类号: C07D207/404 , A61K31/40 , A61K31/425 , A61K31/44 , A61K31/4965 , A61K31/497 , A61K31/5375 , C07D207/16 , C07D207/416 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
摘要: The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein symbols in the formula have the following meanings; A: —CH2— or —S—, B: CH or N, R1 H, a lower alkyl group, etc., X: a single bonding arm, —CO—, —Alk—CO—, —COCH2—, —Alk—O—, —O—CH2—, —SO2—, —S—, —COO—, —CON(R3)—, —Alk—CON(R3)—, —CON(R3)CH2—, —NHCH2—, etc., R3: hydrogen atom or a lower alkyl group, Alk: a lower alkylene group,,and. R2: (1) a cyclic group which may be substituted, (2) a substituted amino group, etc., provided that when X is —CO—, then B is N, or a pharmaceutically acceptable salt thereof.
摘要翻译: 本发明提供由式[I]表示的脂族含氮的五元环化合物:其中式中的符号具有以下含义: A:-CH 2 - 或-S-,B:CH或N,R 1 H,低级烷基等,X:单键键合, -CO-,-Alk-CO-,-COCH 2 - , - Alk-O-,-O-CH 2 - , - SO 2 - ,-S-,-COO-,-CON(R 3) - ,-Alk-CON(R 3) - , - CON(R SUP) CH 3 - , - NHCH 2 - 等,R 3:氢原子或低级烷基 ,Alk:低级亚烷基,和。 R 2:(1)可以被取代的环状基团,(2)取代氨基等,条件是当X是-CO-时,B是N,或药学上可接受的 的盐。
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公开(公告)号:US07666869B2
公开(公告)日:2010-02-23
申请号:US12000024
申请日:2007-12-07
申请人: Kosuke Yasuda , Hiroshi Morimoto , Saburo Kawanami , Masataka Hikota , Takeshi Matsumoto , Kenji Arakawa
发明人: Kosuke Yasuda , Hiroshi Morimoto , Saburo Kawanami , Masataka Hikota , Takeshi Matsumoto , Kenji Arakawa
IPC分类号: A61K31/535 , A61K31/425 , A61K31/496
CPC分类号: C07D207/404 , A61K31/40 , A61K31/425 , A61K31/44 , A61K31/4965 , A61K31/497 , A61K31/5375 , C07D207/16 , C07D207/416 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
摘要: The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein symbols in the formula have the following meanings; A: —CH2— or —S—, B: CH or N, R1: H, a lower alkyl group, etc., X: a single bonding arm, —CO—, -Alk-CO—, —COCH2—, -Alk-O—, —O—CH2—, —SO2—, —S—, —COO—, —CON(R3)—, -Alk-CON(R3)—, —CON(R3)CH2—, —NHCH2—, etc., R3: hydrogen atom or a lower alkyl group, Alk: a lower alkylene group, and R2: (1) a cyclic group which may be substituted, (2) a substituted amino group, etc., provided that when X is —CO—, then B is N, or a pharmaceutically acceptable salt thereof.
摘要翻译: 本发明提供由式[I]表示的脂族含氮的五元环化合物:其中式中的符号具有以下含义: A:-CH 2 - 或-S-,B:CH或N,R 1:H,低级烷基等,X:单键键,-CO-,-Alk-CO-,-COCH2-, AlK-O-,-O-CH 2 - , - SO 2 - , - S - , - COO-,-CON(R 3) - , - Alk-CON(R 3) - , - CON(R 3) 等等,R3:氢原子或低级烷基,Alk:低级亚烷基,R2:(1)可以被取代的环状基团,(2)取代的氨基等,条件是当X 是-CO-,则B为N,或其药学上可接受的盐。
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公开(公告)号:US07332487B2
公开(公告)日:2008-02-19
申请号:US11452923
申请日:2006-06-15
申请人: Kosuke Yasuda , Hiroshi Morimoto , Saburo Kawanami , Masataka Hikota , Takeshi Matsumoto , Kenji Arakawa
发明人: Kosuke Yasuda , Hiroshi Morimoto , Saburo Kawanami , Masataka Hikota , Takeshi Matsumoto , Kenji Arakawa
IPC分类号: A61K31/535 , A61K31/425 , C07D413/12 , C07D277/06 , C07D211/08 , C07D471/02 , C07D239/02
CPC分类号: C07D207/404 , A61K31/40 , A61K31/425 , A61K31/44 , A61K31/4965 , A61K31/497 , A61K31/5375 , C07D207/16 , C07D207/416 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
摘要: The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein symbols in the formula have the following meanings; A: —CH2— or —S—, B: CH or N, R1: H, a lower alkyl group, etc., X: a single bonding arm, —CO—, —Alk—CO—, —COCH2—, —Alk—O—, —O—CH2—, —SO2—, —S—, —COO—, —CON(R3)—, —Alk—CON(R3)—, —CON(R3)CH2—, —NHCH2—, etc., R3: hydrogen atom or a lower alkyl group, Alk: a lower alkylene group, and R2: (1) a cyclic group which may be substituted, (2) a substituted amino group, etc., provided that when X is —CO—, then B is N, or a pharmaceutically acceptable salt thereof.
摘要翻译: 本发明提供由式[I]表示的脂族含氮的五元环化合物:其中式中的符号具有以下含义: A:-CH 2 - 或-S-,B:CH或N,R 1:H,低级烷基等; X:单键结合臂 ,-CO-,-Alk-CO-,-COCH 2 - , - Alk-O-,-O-CH 2 - , - SO 2 - ,-S-,-COO-,-CON(R 3) - ,-Alk-CON(R 3) - , - CON(R 3) OCH 3,CH 2,-NHCH 2 - 等,R 3:氢原子或低级烷基 基团,Alk:低级亚烷基和R 2:(1)可以被取代的环状基团,(2)取代的氨基等,条件是当X是-CO- ,则B为N,或其药学上可接受的盐。
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公开(公告)号:US07160877B2
公开(公告)日:2007-01-09
申请号:US10872442
申请日:2004-06-22
申请人: Kosuke Yasuda , Hiroshi Morimoto , Saburo Kawanami , Masataka Hikota , Takeshi Matsumoto , Kenji Arakawa
发明人: Kosuke Yasuda , Hiroshi Morimoto , Saburo Kawanami , Masataka Hikota , Takeshi Matsumoto , Kenji Arakawa
IPC分类号: A61K31/55 , C07D207/00
CPC分类号: C07D207/404 , A61K31/40 , A61K31/425 , A61K31/44 , A61K31/4965 , A61K31/497 , A61K31/5375 , C07D207/16 , C07D207/416 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
摘要: The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein A represents —CH2— or —S—, R1 represents hydrogen atom, a lower alkyl group, a hydroxy lower alkyl group or a lower-alkoxy lower alkyl group, X represents —N(R3)—, —O— or —CO—, where R3 represents hydrogen atom or a lower alkyl group, and R2 represents (1) a cyclic group which may be substituted, or (2) an amino group which may be substituted, or a pharmaceutically acceptable salt thereof, a method for preparing the above-mentioned compound and a pharmaceutical composition comprising the above-mentioned compound as an effective ingredient.
摘要翻译: 本发明提供由式[I]表示的脂族含氮的5元环化合物:其中A表示-CH 2 - 或-S-,R 1, SUP>表示氢原子,低级烷基,羟基低级烷基或低级烷氧基低级烷基,X表示-N(R 3 O) - , - O-或-CO-, 其中R 3表示氢原子或低级烷基,R 2表示(1)可被取代的环状基团,或(2)可以被取代的环状基团,或 取代或其药学上可接受的盐,制备上述化合物的方法和包含上述化合物作为有效成分的药物组合物。
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公开(公告)号:US07138397B2
公开(公告)日:2006-11-21
申请号:US10398485
申请日:2001-10-05
申请人: Kosuke Yasuda , Hiroshi Morimoto , Saburo Kawanami , Masataka Hikota , Takeshi Matsumoto , Kenji Arakawa
发明人: Kosuke Yasuda , Hiroshi Morimoto , Saburo Kawanami , Masataka Hikota , Takeshi Matsumoto , Kenji Arakawa
IPC分类号: C07D403/12 , A61K31/496
CPC分类号: C07D207/404 , A61K31/40 , A61K31/425 , A61K31/44 , A61K31/4965 , A61K31/497 , A61K31/5375 , C07D207/16 , C07D207/416 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
摘要: The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein symbols in the formula have the following meanings; A: —CH2— or —S—, B: CH or N, R1: H, a lower alkyl group, etc., X: a single bonding arm, —CO—, -Alk-CO—, —COCH2—, -Alk-O—, —O—CH2—, —SO2—, —S—, —COO—, —CON(R3)—, -Alk-CON(R3)—, —CON(R3)CH2—, —NHCH2—, etc., R3: hydrogen atom or a lower alkyl group, Alk: a lower alkylene group, and R2: (1) a cyclic group which may be substituted, (2) a substituted amino group, etc., provided that when X is —CO—, then B is N, or a pharmaceutically acceptable salt thereof.
摘要翻译: 本发明提供由式[I]表示的脂族含氮的五元环化合物:其中式中的符号具有以下含义: A:-CH 2 - 或-S-,B:CH或N,R 1:H,低级烷基等; X:单键结合臂 ,-CO-,-Alk-CO-,-COCH 2 - , - Alk-O-,-O-CH 2 - , - SO 2 - ,-S-,-COO-,-CON(R 3) - ,-Alk-CON(R 3) - , - CON(R 3) OCH 3,CH 2,-NHCH 2 - 等,R 3:氢原子或低级烷基 基团,Alk:低级亚烷基和R 2:(1)可以被取代的环状基团,(2)取代的氨基等,条件是当X是-CO- ,则B为N,或其药学上可接受的盐。
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公开(公告)号:US06849622B2
公开(公告)日:2005-02-01
申请号:US10398486
申请日:2001-10-05
申请人: Kosuke Yasuda , Hiroshi Morimoto , Saburo Kawanami , Masataka Hikota , Takeshi Matsumoto , Kenji Arakawa
发明人: Kosuke Yasuda , Hiroshi Morimoto , Saburo Kawanami , Masataka Hikota , Takeshi Matsumoto , Kenji Arakawa
IPC分类号: A61P3/10 , A61P43/00 , C07D207/16 , C07D207/40 , C07D207/404 , C07D207/416 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D513/04 , A61K31/4439
CPC分类号: C07D207/404 , A61K31/40 , A61K31/425 , A61K31/44 , A61K31/4965 , A61K31/497 , A61K31/5375 , C07D207/16 , C07D207/416 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
摘要: The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein A represents —CH2— or —S—, R1 represents hydrogen atom, a lower alkyl group, a hydroxy lower alkyl group or a lower alkoxy lower alkyl group, X represents —N(R3)—, —O— or —CO—, where R3 represents hydrogen atom or a lower alkyl group, and R2 represents (1) a cyclic group which may be substituted, or (2) an amino group which may be substituted, or a pharmaceutically acceptable salt thereof, a method for preparing the above-mentioned compound and a pharmaceutical composition comprising the above-mentioned compound as an effective ingredient.
摘要翻译: 本发明提供由式[I]表示的脂族含氮的5元环化合物:其中A表示-CH 2 - 或-S-,R 1表示氢原子,低级烷基,羟基低级 烷基或低级烷氧基低级烷基,X表示-N(R 3) - , - O-或-CO-,其中R 3表示氢原子或低级烷基,R 2表示( 1)可被取代的环状基团,或(2)可被取代的氨基或其药学上可接受的盐,制备上述化合物的方法和包含上述化合物作为 有效成分。
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公开(公告)号:US20080081817A1
公开(公告)日:2008-04-03
申请号:US11632725
申请日:2005-07-22
申请人: Iwao Takamuro , Saburo Kawanami , Yasunori Tsuboi , Toshiyuki Himiyama , Yuko Hasegawa , Hideki Mochida , Kouji Nogi
发明人: Iwao Takamuro , Saburo Kawanami , Yasunori Tsuboi , Toshiyuki Himiyama , Yuko Hasegawa , Hideki Mochida , Kouji Nogi
IPC分类号: A61K31/497 , A61K31/519 , A61P43/00 , C07D401/00 , C07D487/00
CPC分类号: C07D471/04 , C07D487/04
摘要: A novel nitrogenous fused bicyclic compound represented by the following general formula [1] or a pharmacologically acceptable salt of the compound. They have excellent SK channel blocking activity and are useful as a medicine. [I] (In the formula, R0 represents hydrogen, halogeno, etc.; R1 represents a group represented by the formula (a) or (b); A represents a group represented by the formula (X) or (Y); D1, D2 and D3 each represents N or CH; R2 represents halogeno or optionally halogenated lower alkyl, etc.; R3 represents hydrogen or lower alkyl; and Q represents lower alkylene.)
摘要翻译: 由以下通式[1]表示的新型含氮稠合双环化合物或该化合物的药理学上可接受的盐。 它们具有优异的SK通道阻断活性,可用作药物。 [I](式中,R 0表示氢,卤素等; R 1表示由式(a)或(b)表示的基团; A 表示由式(X)或(Y)表示的基团; D 1,D 2和D 3各自表示N或CH; R 2表示卤代或任选卤代的低级烷基等; R 3表示氢或低级烷基; Q表示低级亚烷基。)
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