公开(公告)号：US06437146B1

公开(公告)日：2002-08-20

申请号：US09787433

申请日：2001-04-20

申请人： Kouji Hattori ,  Akira Tanaka ,  Yutaka Kono ,  Shoko Nakazato

发明人： Kouji Hattori ,  Akira Tanaka ,  Yutaka Kono ,  Shoko Nakazato

IPC分类号： C07D26336

CPC分类号： C07D413/12 ,  C07D263/32 ,  C07D413/10

摘要： Oxazole compounds of formula (I), wherein R1 is aryl which may be substituted with halogen(s), R2 is aryl which may be substituted with halogen(s), X is single bond, (a) or SO2, R3 and R4 are independently hydrogen or suitable substituent, (wherein X is (a), neither R3 nor R4 is hydrogen), R3 and R4 may be linked together to form (b), (b) is N-containing heterocyclic group which may be substituted with one or more suitable substituent(s), R5 is hydrogen, etc., A1 is lower alkylene or single bond, (c) is cyclo(C3-C9)alkane or cyclo(C5-C9)alkene, or a pro-drug thereof, or a pharmaceutically acceptable salt thereof, which are useful as medicament.

摘要翻译： 式（I）的恶唑化合物，其中R 1为可被卤素取代的芳基，R 2为可被卤素取代的芳基，X为单键，（a）或SO 2，R 3和R 4为 （其中X是（a），R3和R4都不是氢），R3和R4可以连接在一起形成（b），（b）是可以被一个取代的含氮杂环基 或更合适的取代基，R5是氢等，A1是低级亚烷基或单键，（c）是环（C 3 -C 9）烷烃或环（C 5 -C 9）烯烃或其前药， 或其药学上可接受的盐，其可用作药物。

公开(公告)号：US08974666B2

公开(公告)日：2015-03-10

申请号：US12681281

申请日：2007-10-02

申请人： Yutaka Kono ,  Masayuki Nishimura ,  Bob Boughtflower ,  Przemyslaw Stasica

发明人： Yutaka Kono ,  Masayuki Nishimura ,  Bob Boughtflower ,  Przemyslaw Stasica

IPC分类号： B01D15/20 ,  B01D15/24

CPC分类号： B01D15/203 ,  B01D15/20 ,  B01D15/24

摘要： A solution containing a target compound is passed through a trap column (14) to capture the target compound in the column (14). Thereafter, wash water is introduced in the trap column (14). Then, the setting of a six-port valve (7) is changed and an on/off valve (6) is opened to introduce nitrogen gas through a supply-side passage (8) in the trap column (14). In this stage, the nitrogen gas is warmed by means of a heat-exchange block (10), and the trap column (14) is warmed via a column rack (15). Any water remaining in the trap column (14) is initially thrust upwards by the nitrogen gas, to be extruded from an exit edge (14b) and discharged through a discharge-side passage (20). Furthermore, any water adhering to adsorbent or the inner wall surface of the trap column (14) is quickly vaporized and carried away by the nitrogen gas. In this manner, any water remaining in the trap column (14) can be rapidly removed, so that no water will be included in an eluate in the subsequent stage where a solvent with a strong elution power is introduced into the trap column (14) to collect the eluate. Thus, the eluate is rapidly vaporized and dried, so that the target compound in solid forms can be efficiently collected.

摘要翻译： 含有目标化合物的溶液通过捕集塔（14）以捕获柱（14）中的目标化合物。 此后，将洗涤水引入捕集塔（14）中。 然后，改变六口阀（7）的设定，开通开闭阀（6），将氮气通过捕集塔（14）内的供给侧通路（8）引入。 在这个阶段，氮气通过热交换块（10）加热，并且捕集塔（14）通过柱架（15）加热。 残留在捕集塔（14）中的任何水最初被氮气向上推动，从出口边缘（14b）挤出并通过排放侧通道（20）排出。 此外，附着于吸附剂或捕集塔（14）的内壁表面的任何水都被氮气迅速气化并带走。 以这种方式，可以快速除去残留在捕集塔（14）中的任何水，使得在后续阶段，洗脱液中不会含有水，其中具有强洗脱力的溶剂被引入捕集塔（14） 收集洗脱液。 因此，洗脱液迅速蒸发并干燥，从而可以有效地收集固体形式的目标化合物。

公开(公告)号：USD295862S

公开(公告)日：1988-05-24

申请号：US661628

申请日：1984-10-17

申请人： Hiroshi Yonekura ,  Yutaka Kono

设计人： Hiroshi Yonekura ,  Yutaka Kono

公开(公告)号：US20100258485A1

公开(公告)日：2010-10-14

申请号：US12681281

申请日：2007-10-02

申请人： Yutaka Kono ,  Masayuki Nishimura ,  Bob Boughtflower ,  Przemyslaw Stasica

发明人： Yutaka Kono ,  Masayuki Nishimura ,  Bob Boughtflower ,  Przemyslaw Stasica

IPC分类号： B01D15/10

CPC分类号： B01D15/203 ,  B01D15/20 ,  B01D15/24

摘要： A solution containing a target compound is passed through a trap column (14) to capture the target compound in the column (14). Thereafter, wash water is introduced in the trap column (14). Then, the setting of a six-port valve (7) is changed and an on/off valve (6) is opened to introduce nitrogen gas through a supply-side passage (8) in the trap column (14). In this stage, the nitrogen gas is warmed by means of a heat-exchange block (10), and the trap column (14) is warmed via a column rack (15). Any water remaining in the trap column (14) is initially thrust upwards by the nitrogen gas, to be extruded from an exit edge (14b) and discharged through a discharge-side passage (20). Furthermore, any water adhering to adsorbent or the inner wall surface of the trap column (14) is quickly vaporized and carried away by the nitrogen gas. In this manner, any water remaining in the trap column (14) can be rapidly removed, so that no water will be included in an eluate in the subsequent stage where a solvent with a strong elution power is introduced into the trap column (14) to collect the eluate. Thus, the eluate is rapidly vaporized and dried, so that the target compound in solid forms can be efficiently collected.

摘要翻译： 含有目标化合物的溶液通过捕集塔（14）以捕获柱（14）中的目标化合物。 此后，将洗涤水引入捕集塔（14）中。 然后，改变六口阀（7）的设定，开通开闭阀（6），将氮气通过捕集塔（14）内的供给侧通路（8）引入。 在这个阶段，氮气通过热交换块（10）加热，并且捕集塔（14）通过柱架（15）加热。 残留在捕集塔（14）中的任何水最初被氮气向上推动，从出口边缘（14b）挤出并通过排放侧通道（20）排出。 此外，附着于吸附剂或捕集塔（14）的内壁表面的任何水都被氮气迅速气化并带走。 以这种方式，可以快速除去残留在捕集塔（14）中的任何水，使得在后续阶段，洗脱液中不会含有水，其中具有强洗脱力的溶剂被引入捕集塔（14） 收集洗脱液。 因此，洗脱液迅速蒸发并干燥，从而能够有效地收集固体形式的目标化合物。

公开(公告)号：USD412317S

公开(公告)日：1999-07-27

申请号：US93050

申请日：1998-09-02

申请人： Toshio Horiki ,  Tetsuji Abe ,  Yutaka Kono

设计人： Toshio Horiki ,  Tetsuji Abe ,  Yutaka Kono

公开(公告)号：US4087980A

公开(公告)日：1978-05-09

申请号：US716874

申请日：1976-08-23

申请人： Yutaka Kono

发明人： Yutaka Kono

IPC分类号： B63C11/38 ,  B63C11/44 ,  B63C11/00

CPC分类号： B63C11/44 ,  B63C11/38

摘要： This invention relates to a safety submarine spherical air chamber made of a flexible material wherein persons are able to observe the undersea condition and the seabed from the scientific or recreational point of view by maintaining the atmospheric pressure of the above spherically expanded chamber approximately equivalent to the sea water pressure therearound, and then by floating therein a floating base on which they can stay.

摘要翻译： 本发明涉及一种由柔性材料制成的安全潜艇球形空气室，其中人们能够从科学或娱乐的角度观察海底状况和海床，通过将上述球形膨胀室的大气压维持在大约相当于 周围的海水压力，然后漂浮在其上可以停留的浮动基座。

公开(公告)号：US08968561B2

公开(公告)日：2015-03-03

申请号：US12681318

申请日：2007-10-02

申请人： Yutaka Kono ,  Masayuki Nishimura ,  Bob Boughtflower ,  Przemyslaw Stasica

发明人： Yutaka Kono ,  Masayuki Nishimura ,  Bob Boughtflower ,  Przemyslaw Stasica

IPC分类号： B01D15/20 ,  B01D15/16

CPC分类号： B01D15/20 ,  B01D15/166

摘要： A mixed liquid passage (31) is connected to a trapping passage (22) at a point upstream of a trap column (23). A mixture of a diluting liquid and an additive agent, which are respectively drawn and sent by pumps (35) and (36), is supplied into the mixed liquid passage (31). When an eluate containing a target compound is passed through the trap column (23), the eluate is diluted with the diluting liquid and hence its elution capability decreases, so that the target compound can be easily captured in the trap column (23). Meanwhile, the solubility of the mobile phase in the eluate decreases, causing not only the target component but also foreign compounds to more easily precipitate. However, their precipitation is prevented by the effect of the additive agent. Thus, clogging of the trap column (23) or pipes is prevented.

摘要翻译： 混合液体通道（31）在捕集塔（23）上游的一个点连接到捕集通道（22）。 将分别由泵（35）和（36）抽出并送出的稀释液和添加剂的混合物供给到混合液通路（31）中。 当含有目标化合物的洗脱液通过捕集塔（23）时，用稀释液稀释洗脱液，因此其洗脱能力降低，使得目标化合物可以容易地捕获在捕集塔（23）中。 同时，流动相在洗脱液中的溶解度降低，不仅引起目标成分，而且使外来化合物更容易沉淀。 然而，通过添加剂的作用可防止其沉淀。 因此，阻止了捕集塔（23）或管道的堵塞。

公开(公告)号：US20100300627A1

公开(公告)日：2010-12-02

申请号：US12681323

申请日：2007-10-02

申请人： Yutaka Kono ,  Masayuki Nishimura ,  Bob Boughtflower ,  Przemyslaw Stasica

发明人： Yutaka Kono ,  Masayuki Nishimura ,  Bob Boughtflower ,  Przemyslaw Stasica

IPC分类号： B01D1/18

CPC分类号： B01D15/24

摘要： Collection containers (17) are heated by head conduction from a container rack (18) with a heater (19) as the heat source. When an eluting solvent is supplied into a trap column (7) by a pump (5), an eluate containing a target compound exiting from the column (7) flows through a preparative separation passage (13) and drips from a solution nozzle (13a), and this solution is separated into fine droplets by a gas stream blowing from a gas ejection nozzle (15a). When a droplet touches an inner wall of the container (17), the volatile solvent immediately vaporizes, leaving the target compound precipitated in solid forms on the inner wall. Thus, the process of vaporizing and drying the eluate to collect the target compound is completed within a short period of time. This process can be performed online and hence is suitable for laborsaving.

摘要翻译： 收集容器（17）通过头管传导从具有作为热源的加热器（19）的容器架（18）加热。 当通过泵（5）将洗脱溶剂供应到捕集塔（7）中时，含有从柱（7）排出的目标化合物的洗脱液流过制备分离通道（13），并从溶液喷嘴（13a） ），并且通过从气体喷射喷嘴（15a）吹送的气流将该溶液分离成细小液滴。 当液滴接触容器（17）的内壁时，挥发性溶剂立即蒸发，使目标化合物以固体形式沉淀在内壁上。 因此，蒸发并干燥洗脱液以收集目标化合物的过程在短时间内完成。 该过程可以在线执行，因此适合于劳动保护。

公开(公告)号：US20100276350A1

公开(公告)日：2010-11-04

申请号：US12681318

申请日：2007-10-02

申请人： Yutaka Kono ,  Masayuki Nishimura ,  Bob Boughtflower ,  Przemyslaw Stasica

发明人： Yutaka Kono ,  Masayuki Nishimura ,  Bob Boughtflower ,  Przemyslaw Stasica

IPC分类号： B01D15/08

CPC分类号： B01D15/20 ,  B01D15/166

摘要： A mixed liquid passage (31) is connected to a trapping passage (22) at a point upstream of a trap column (23). A mixture of a diluting liquid and an additive agent, which are respectively drawn and sent by pumps (35) and (36), is supplied into the mixed liquid passage (31). When an eluate containing a target compound is passed through the trap column (23), the eluate is diluted with the diluting liquid and hence its elution capability decreases, so that the target compound can be easily captured in the trap column (23). Meanwhile, the solubility of the mobile phase in the eluate decreases, causing not only the target component but also foreign compounds to more easily precipitate. However, their precipitation is prevented by the effect of the additive agent. Thus, clogging of the trap column (23) or pipes is prevented.

摘要翻译： 混合液体通道（31）在捕集塔（23）上游的一个点连接到捕集通道（22）。 将分别由泵（35）和（36）抽出并送出的稀释液和添加剂的混合物供给到混合液通路（31）中。 当含有目标化合物的洗脱液通过捕集塔（23）时，用稀释液稀释洗脱液，因此其洗脱能力降低，使得目标化合物可以容易地捕获在捕集塔（23）中。 同时，流动相在洗脱液中的溶解度降低，不仅引起目标成分，而且使外来化合物更容易沉淀。 然而，通过添加剂的作用可防止其沉淀。 因此，阻止了捕集塔（23）或管道的堵塞。

公开(公告)号：USD378084S

公开(公告)日：1997-02-18

申请号：US51546

申请日：1996-03-13

申请人： Takayuki Hayami ,  Tetsuya Imamura ,  Yutaka Kono ,  Makoto Fujita

设计人： Takayuki Hayami ,  Tetsuya Imamura ,  Yutaka Kono ,  Makoto Fujita