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公开(公告)号：US20050273046A1
公开(公告)日：2005-12-08
申请号：US10860557
申请日：2004-06-03
CPC分类号： A61M37/0015 , A61K9/0009 , A61K9/0021 , A61K9/06 , A61K9/16 , A61M2037/0023 , A61N1/306 , A61N1/325
摘要： A device for the transdermal delivery of a therapeutic agent to a biological subject that includes a first electrode comprising a first array of electrically conductive microprojections for providing electrical communication through a skin portion of the subject to a second electrode comprising a second array of electrically conductive microprojections. Additionally, a reservoir for holding the therapeutic agent surrounding the first electrode and a pulse generator for providing an exponential decay pulse between the first and second electrodes may be provided. A method includes the steps of piercing a stratum corneum layer of skin with two arrays of conductive microprojections, encapsulating the therapeutic agent into biocompatible charged carriers, surrounding the conductive microprojections with the therapeutic agent, generating an exponential decay pulse between the two arrays of conductive microprojections to create a non-uniform electrical field and electrokinetically driving the therapeutic agent through the stratum corneum layer of skin.
摘要翻译： 用于将治疗剂透皮递送至生物受试者的装置，其包括第一电极，所述第一电极包括第一导电微突出阵列，用于提供通过所述受试者的皮肤部分的电连通至第二电极，所述第二电极包括第二阵列的导电微突出物 。 此外，可以提供用于保持围绕第一电极的治疗剂的储存器和用于在第一和第二电极之间提供指数衰减脉冲的脉冲发生器。 一种方法包括以两个阵列的导电微突出物刺穿角质层皮肤层的步骤，将治疗剂包封在生物相容的带电荷的载体中，用治疗剂包围导电微突出物，在导电微突出体的两个阵列之间产生指数衰减脉冲 以产生不均匀的电场并通过皮肤的角质层电动驱动治疗剂。
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公开(公告)号：US20060058602A1
公开(公告)日：2006-03-16
申请号：US10920036
申请日：2004-08-17
IPC分类号： A61B5/05
CPC分类号： A61B5/14532 , A61B5/14514 , A61B5/14546 , A61B5/1486 , A61N1/303
摘要： A device useful for measuring an analyte in the interstitial fluid of an animal comprising an array chamber having an array of one or more microprojections and a detection compartment comprising a sensor in selective fluid communication with the array chamber. Also included are two extraction electrodes for inducing electrotransport of the interstitial fluid from the animal into the array chamber. A method includes the steps of forming a plurality of microchannels through a stratum corneum layer of an epidermis of the animal, inducing electrotransport of interstitial fluid containing the analyte through the microchannels and mixing one or more materials with the interstitial fluid to form a mixture, contacting the mixture with detection electrodes and analyzing the mixture with the detection electrodes.
摘要翻译： 一种用于测量动物的间质液中的分析物的装置，包括具有一个或多个微突出物阵列的阵列室和包括与阵列室选择性流体连通的传感器的检测室。 还包括两个提取电极，用于诱导间质液体从动物的电转移到阵列室中。 一种方法包括以下步骤：通过动物表皮的角质层形成多个微通道，通过微通道诱导含有分析物的间质液的电转运并将一种或多种材料与间质液混合以形成混合物，接触 与检测电极的混合物，并用检测电极分析混合物。
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