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公开(公告)号：US20130156522A1
公开(公告)日：2013-06-20
申请号：US13328141
申请日：2011-12-16
申请人： James Magnuson
发明人： James Magnuson
CPC分类号： B23Q15/22 , B21B15/0007 , B23C3/002 , B23K7/002 , B23K10/00 , Y10T409/300896 , Y10T409/30112
摘要： A cutting device for a mill plate including a cutting tool supported for movement in a Y-direction and cutting in a Z-direction, and a conveyor for conveying a mill plate in the X-direction. A measuring device is movable in the X-direction along one side of a mill plate supported on the conveyor to map the X-axis and Y-axis positions of the mill plate one side. Positioning guides adjacent one side of the conveyor are adjusted in the Y-direction to follow the mapped Y-axis position of the mill plate one side at the X-axis position of the mill plate one side aligned with the positioning guides as the mill plate is conveyed in the X-direction. A clamp on the side opposite the mill plate one side is adapted to push the mill plate opposite side in the Y-direction to maintain the mill plate one side in engagement with the positioning guides.
摘要翻译： 一种用于碾磨机的切割装置，包括支撑在Y方向上移动并沿Z方向切割的切割工具，以及用于在X方向上输送研磨板的输送机。 测量装置可以沿着支撑在输送机上的研磨板的一侧在X方向上移动，以将轧机板的X轴和Y轴位置映射到一侧。 在Y方向上相邻一侧的定位导向器在Y方向上调整为跟随在与定位导轨对准的铣板一侧的X轴位置上的研磨板一侧的Y轴位置作为研磨盘 在X方向传送。 在与轧机板一侧相对的一侧上的夹具适于在Y方向上推动铣板相对侧，以将轧机板一侧与定位导向件接合。
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公开(公告)号：US20060058602A1
公开(公告)日：2006-03-16
申请号：US10920036
申请日：2004-08-17
IPC分类号： A61B5/05
CPC分类号： A61B5/14532 , A61B5/14514 , A61B5/14546 , A61B5/1486 , A61N1/303
摘要： A device useful for measuring an analyte in the interstitial fluid of an animal comprising an array chamber having an array of one or more microprojections and a detection compartment comprising a sensor in selective fluid communication with the array chamber. Also included are two extraction electrodes for inducing electrotransport of the interstitial fluid from the animal into the array chamber. A method includes the steps of forming a plurality of microchannels through a stratum corneum layer of an epidermis of the animal, inducing electrotransport of interstitial fluid containing the analyte through the microchannels and mixing one or more materials with the interstitial fluid to form a mixture, contacting the mixture with detection electrodes and analyzing the mixture with the detection electrodes.
摘要翻译： 一种用于测量动物的间质液中的分析物的装置，包括具有一个或多个微突出物阵列的阵列室和包括与阵列室选择性流体连通的传感器的检测室。 还包括两个提取电极，用于诱导间质液体从动物的电转移到阵列室中。 一种方法包括以下步骤：通过动物表皮的角质层形成多个微通道，通过微通道诱导含有分析物的间质液的电转运并将一种或多种材料与间质液混合以形成混合物，接触 与检测电极的混合物，并用检测电极分析混合物。
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公开(公告)号：US20050273046A1
公开(公告)日：2005-12-08
申请号：US10860557
申请日：2004-06-03
CPC分类号： A61M37/0015 , A61K9/0009 , A61K9/0021 , A61K9/06 , A61K9/16 , A61M2037/0023 , A61N1/306 , A61N1/325
摘要： A device for the transdermal delivery of a therapeutic agent to a biological subject that includes a first electrode comprising a first array of electrically conductive microprojections for providing electrical communication through a skin portion of the subject to a second electrode comprising a second array of electrically conductive microprojections. Additionally, a reservoir for holding the therapeutic agent surrounding the first electrode and a pulse generator for providing an exponential decay pulse between the first and second electrodes may be provided. A method includes the steps of piercing a stratum corneum layer of skin with two arrays of conductive microprojections, encapsulating the therapeutic agent into biocompatible charged carriers, surrounding the conductive microprojections with the therapeutic agent, generating an exponential decay pulse between the two arrays of conductive microprojections to create a non-uniform electrical field and electrokinetically driving the therapeutic agent through the stratum corneum layer of skin.
摘要翻译： 用于将治疗剂透皮递送至生物受试者的装置，其包括第一电极，所述第一电极包括第一导电微突出阵列，用于提供通过所述受试者的皮肤部分的电连通至第二电极，所述第二电极包括第二阵列的导电微突出物 。 此外，可以提供用于保持围绕第一电极的治疗剂的储存器和用于在第一和第二电极之间提供指数衰减脉冲的脉冲发生器。 一种方法包括以两个阵列的导电微突出物刺穿角质层皮肤层的步骤，将治疗剂包封在生物相容的带电荷的载体中，用治疗剂包围导电微突出物，在导电微突出体的两个阵列之间产生指数衰减脉冲 以产生不均匀的电场并通过皮肤的角质层电动驱动治疗剂。
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公开(公告)号：US1823618A
公开(公告)日：1931-09-15
申请号：US30075928
申请日：1928-08-20
申请人： JAMES MAGNUSON JOHN
发明人： JAMES MAGNUSON JOHN
IPC分类号： F16N21/02
CPC分类号： F16N21/02
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公开(公告)号：US09073162B2
公开(公告)日：2015-07-07
申请号：US13328141
申请日：2011-12-16
申请人： James Magnuson
发明人： James Magnuson
CPC分类号： B23Q15/22 , B21B15/0007 , B23C3/002 , B23K7/002 , B23K10/00 , Y10T409/300896 , Y10T409/30112
摘要： A cutting device for a mill plate including a cutting tool supported for movement in a Y-direction and cutting in a Z-direction, and a conveyor for conveying a mill plate in the X-direction. A measuring device is movable in the X-direction along one side of a mill plate supported on the conveyor to map the X-axis and Y-axis positions of the mill plate one side. Positioning guides adjacent one side of the conveyor are adjusted in the Y-direction to follow the mapped Y-axis position of the mill plate one side at the X-axis position of the mill plate one side aligned with the positioning guides as the mill plate is conveyed in the X-direction. A clamp on the side opposite the mill plate one side is adapted to push the mill plate opposite side in the Y-direction to maintain the mill plate one side in engagement with the positioning guides.
摘要翻译： 一种用于碾磨机的切割装置，包括支撑在Y方向上移动并沿Z方向切割的切割工具，以及用于在X方向上输送轧机板的输送机。 测量装置可以沿着支撑在输送机上的研磨板的一侧在X方向上移动，以将轧机板的X轴和Y轴位置映射到一侧。 在Y方向上相邻一侧的定位导向器在Y方向上调整为跟随在与定位导轨对准的铣板一侧的X轴位置上的研磨板一侧的Y轴位置作为研磨盘 在X方向传送。 在与轧机板一侧相对的一侧上的夹具适于在Y方向上推动铣板相对侧，以将轧机板一侧与定位导向件接合。
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