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公开(公告)号：US09476893B2
公开(公告)日：2016-10-25
申请号：US13321072
申请日：2010-05-10
IPC分类号： G01N35/00
CPC分类号： G01N35/00663 , G01N35/00623 , G01N2035/00702 , G01N2035/0097
摘要： Provided are an automated analyzer and an automatic analysis method for highly accurately determining presence or absence of abnormality based on reaction process data obtained when concentration of a chemical component or an activity level of an enzyme is measured. The reaction process data is approximated by a function, and shape feature quantities indicating features of a shape of a curve section at an early stage of reaction are calculated. The obtained shape feature quantities are used to determine the presence or absence of abnormality.
摘要翻译： 本发明提供一种自动分析装置和自动分析方法，用于根据测定化学成分浓度或酶活性水平时获得的反应过程数据，高精度地确定异常存在或不存在。 反应过程数据由功能近似，并且计算表示在反应初期的曲线部分的形状的特征的形状特征量。 获得的形状特征量用于确定是否存在异常。
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公开(公告)号：US09310388B2
公开(公告)日：2016-04-12
申请号：US13318535
申请日：2010-04-12
CPC分类号： G01N35/00603 , G01N21/272
摘要： In known automatic analyzers for detecting an abnormality by approximating reaction process data using a function, accuracy of detecting a reaction abnormality is degraded because of poor approximation accuracy depending on test items. Data processing means stores the absorbance and time of day at which the absorbance is measured as time-series data. Letting x denote absorbance, t denote time, and * denote a symbol representing multiplication, we have a function x=a0+a1*exp(−k1*t)+a2*exp(−k2*t). Values of parameters a0, a1, a2, ai, k1, and k2 are calculated so that a difference between the absorbance at the measured time calculated using the above expression and the time-series data is minimal, and presence of an abnormality is determined based on the parameter values.
摘要翻译： 在用于通过使用功能近似反应过程数据来检测异常的已知的自动分析器中，由于根据测试项目的近似精度不足，检测反应异常的精度降低。 数据处理装置将吸光度和吸光度时间的时间存储为时间序列数据。 令x表示吸光度，t表示时间，*表示表示乘法的符号，我们有函数x = a0 + a1 * exp（-k1 * t）+ a2 * exp（-k2 * t）。 计算参数a0，a1，a2，ai，k1和k2的值，使得使用上述表达式计算的测量时间的吸光度与时间序列数据之间的差异最小，并且基于 对参数值。
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公开(公告)号：US09562917B2
公开(公告)日：2017-02-07
申请号：US14117717
申请日：2012-04-17
CPC分类号： G01N35/00584 , G01N35/00693 , G01N2035/00673 , G01N2035/00702 , G01N2035/0453
摘要： Accuracy control of an automatic analysis device that mixes a sample and a reagent to measure temporal change of a mixed solution is realized. A plurality of measurement point data is acquired from a reaction process of the sample and the reagent. Parameters and test values of approximate equations for approximating the plurality of measurement point data are accumulated in a storage unit. A distribution map of reference data corresponding to the parameters or the test values is created based on predetermined numbers of the parameters or the test values accumulated in the storage unit. Next, a plurality of screens for individually superimposing, on the distribution map, curved lines corresponding to a plurality of regression function candidates obtained by applying a plurality of regression functions are arranged and presented on a display screen, so as to approximate the data to the distribution map of the reference data.
摘要翻译： 实现了混合样品和试剂以测量混合溶液的时间变化的自动分析装置的精度控制。 从样品和试剂的反应过程获取多个测量点数据。 用于近似多个测量点数据的近似等式的参数和测试值被累积在存储单元中。 基于在存储单元中累积的参数或测试值的预定数量来创建与参数或测试值相对应的参考数据的分布图。 接下来，在分配图上单独叠加多个屏幕，将与通过应用多个回归函数获得的多个回归函数候选对应的曲线布置并呈现在显示屏上，以将数据近似为 参考数据的分布图。
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公开(公告)号：US09488667B2
公开(公告)日：2016-11-08
申请号：US13318819
申请日：2010-04-12
CPC分类号： G01N35/00613 , G01N2035/0097
摘要： To change a photometric time for each item or to change a measurement time for each specimen so that time required for biochemical measurement can be reduced, an index that indicates an end of a reaction is required. Unfortunately, however, no methods have been available for determining the end of the reaction. In measuring a substance to be measured contained in a sample, a parameter in an approximate expression is calculated using a measured value that changes with time, a degree of convergence of a reaction is determined according to a degree of convergence of the parameter, and a measured value at the end of the reaction is calculated using the parameter at a point in time at which it is determined that the reaction has converged.
摘要翻译： 要更改每个项目的光度时间或更改每个样品的测量时间，以便可以减少生物化学测量所需的时间，则需要指示反应结束的指标。 然而，不幸的是，没有方法可用于确定反应的结束。 在测定样品中含有的待测物质时，使用随时间变化的测定值来计算近似表达式中的参数，根据参数的收敛程度确定反应的收敛程度， 使用在确定反应已经收敛的时间点的参数来计算反应结束时的测量值。
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公开(公告)号：US20140136123A1
公开(公告)日：2014-05-15
申请号：US14117717
申请日：2012-04-17
IPC分类号： G01N35/00
CPC分类号： G01N35/00584 , G01N35/00693 , G01N2035/00673 , G01N2035/00702 , G01N2035/0453
摘要： Accuracy control of an automatic analysis device that mixes a sample and a reagent to measure temporal change of a mixed solution is realized. A plurality of measurement point data is acquired from a reaction process of the sample and the reagent. Parameters and test values of approximate equations for approximating the plurality of measurement point data are accumulated in a storage unit. A distribution map of reference data corresponding to the parameters or the test values is created based on predetermined numbers of the parameters or the test values accumulated in the storage unit. Next, a plurality of screens for individually superimposing, on the distribution map, curved lines corresponding to a plurality of regression function candidates obtained by applying a plurality of regression functions are arranged and presented on a display screen, so as to approximate the data to the distribution map of the reference data.
摘要翻译： 实现了混合样品和试剂以测量混合溶液的时间变化的自动分析装置的精度控制。 从样品和试剂的反应过程获取多个测量点数据。 用于近似多个测量点数据的近似等式的参数和测试值被累积在存储单元中。 基于在存储单元中累积的参数或测试值的预定数量来创建与参数或测试值相对应的参考数据的分布图。 接下来，在分配图上单独叠加多个屏幕，将与通过应用多个回归函数获得的多个回归函数候选对应的曲线布置并呈现在显示屏上，以将数据近似为 参考数据的分布图。
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公开(公告)号：US10352864B2
公开(公告)日：2019-07-16
申请号：US13808743
申请日：2011-07-04
摘要： An automatic analyzer includes sample vessels containing samples to be measured and; reaction vessels in which to mix a sample and a reagent. A sample dispenser 5 dispenses a sample from any of the sample vessels to any of the reaction vessels. A reagent dispenser dispenses a reagent from a reagent vessel to a reaction vessel, and a stirrer stirs the sample-reagent mix contained in the reaction vessel. A photometric measurement unit is provided for obtaining multiple measurement data points during the progress of reaction of a mixed solution. At least one approximation formula is performed and an approximation curve from the measurement data points is generated. A shape descriptor is calculated from the approximation curve and abnormalities based on the shape descriptor are determined. This not only allows abnormalities to be detected accurately from each measurement result, but also allows the causes of the abnormalities to be identified.
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公开(公告)号：US20130046480A1
公开(公告)日：2013-02-21
申请号：US13641881
申请日：2011-04-05
CPC分类号： G01N21/272 , G01N21/78 , G01N35/00584 , G01N35/00693 , G01N2035/00465
摘要： There is provided a technique for automatically determining or predicting a line range specific to a sample that appears in a reaction curve in an automated analyzer for mixing a specimen and a reagent and measuring a change in a mixture of the specimen and the reagent with time. This invention approximates reaction curve data by a function and automatically determines a curve part at an early stage or a second stage of a reaction. The invention determines a line range not including a curve part for each sample and calculates a laboratory test value using absorbance data within the determined line range. This invention also automatically determines a start time of line at the early stage of the reaction on the basis of absorbance data obtained up to a point halfway through the reaction curve, predicts a line range on the basis of the end time of line and a planned end time of line, and calculates a predictive value on the basis of a result of the prediction.
摘要翻译： 提供了一种用于自动确定或预测在自动分析器中出现在反应曲线中的样品特异性的线范围的技术，用于混合样品和试剂，并测量样品和试剂的混合物随时间的变化。 本发明通过功能近似反应曲线数据，并在反应的早期阶段或第二阶段自动确定曲线部分。 本发明确定不包括每个样品的曲线部分的线范围，并使用确定的线范围内的吸光度数据计算实验室测试值。 本发明还根据通过反应曲线中途的一点获得的吸光度数据自动确定反应初期的起始时间，基于线的结束时间和计划的预测线范围 并且基于预测结果来计算预测值。
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公开(公告)号：US20120065898A1
公开(公告)日：2012-03-15
申请号：US13318819
申请日：2010-04-12
CPC分类号： G01N35/00613 , G01N2035/0097
摘要： To change a photometric time for each item or to change a measurement time for each specimen so that time required for biochemical measurement can be reduced, an index that indicates an end of a reaction is required. Unfortunately, however, no methods have been available for determining the end of the reaction. In measuring a substance to be measured contained in a sample, a parameter in an approximate expression is calculated using a measured value that changes with time, a degree of convergence of a reaction is determined according to a degree of convergence of the parameter, and a measured value at the end of the reaction is calculated using the parameter at a point in time at which it is determined that the reaction has converged.
摘要翻译： 要更改每个项目的光度时间或更改每个样品的测量时间，以便可以减少生物化学测量所需的时间，则需要指示反应结束的指标。 然而，不幸的是，没有方法可用于确定反应的结束。 在测定样品中含有的待测物质时，使用随时间变化的测定值来计算近似表达式中的参数，根据参数的收敛程度确定反应的收敛程度， 使用在确定反应已经收敛的时间点的参数来计算反应结束时的测量值。
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公开(公告)号：US20130122596A1
公开(公告)日：2013-05-16
申请号：US13808743
申请日：2011-07-04
CPC分类号： G01N21/75 , B01F11/0266 , B01F15/00214 , G01N21/272 , G01N35/00594 , G01N35/00603 , G01N35/00623 , G01N35/00663 , G01N2035/00465 , G01N2035/00702 , G01N2035/0097 , G16C20/10 , Y10T436/11
摘要： An automatic analyzer includes sample vessels containing samples to be measured and reaction vessels in which to mix a sample and a reagent. A sample dispenser 5 dispenses a sample from any of the sample vessels to any of the reaction vessels. A reagent dispenser dispenses a reagent from a reagent vessel to a reaction vessel, and a stirrer stirs the sample-reagent mix contained in the reaction vessel. A photometric measurement unit is provided for obtaining multiple measurement data points during the progress of reaction of a mixed solution. At least one approximation formula is performed and an approximation curve from the measurement data points is generated. A shape descriptor is calculated from the approximation curve and abnormalities based on the shape descriptor are determined. This not only allows abnormalities to be detected accurately from each measurement result, but also allows the causes of the abnormalities to be identified.
摘要翻译： 自动分析仪包括含有要测量样品的样品容器和混合样品和试剂的反应容器。 样品分配器5将样品从任何样品容器分配到任何反应容器中。 试剂分配器将试剂从试剂容器分配到反应容器中，并且搅拌器搅拌反应容器中包含的样品 - 试剂混合物。 提供了一种光度测量单元，用于在混合溶液的反应进程期间获得多个测量数据点。 执行至少一个近似公式，并且生成来自测量数据点的近似曲线。 根据近似曲线计算形状描述符，并确定基于形状描述符的异常。 这不仅允许从每个测量结果准确地检测异常，而且允许识别异常的原因。
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公开(公告)号：US20120109534A1
公开(公告)日：2012-05-03
申请号：US13318535
申请日：2010-04-12
IPC分类号： G06F19/00
CPC分类号： G01N35/00603 , G01N21/272
摘要： In known automatic analyzers for detecting an abnormality by approximating reaction process data using a function, accuracy of detecting a reaction abnormality is degraded because of poor approximation accuracy depending on test items. Data processing means stores the absorbance and time of day at which the absorbance is measured as time-series data. Letting x denote absorbance, t denote time, and * denote a symbol representing multiplication, we have a function x=a0+a1*exp(−k1*t)+a2*exp(−k2*t). Values of parameters a0, a1, a2, ai, k1, and k2 are calculated so that a difference between the absorbance at the measured time calculated using the above expression and the time-series data is minimal, and presence of an abnormality is determined based on the parameter values.
摘要翻译： 在用于通过使用功能近似反应过程数据来检测异常的已知的自动分析器中，由于根据测试项目的近似精度不足，检测反应异常的精度降低。 数据处理装置将吸光度和吸光度时间的时间存储为时间序列数据。 令x表示吸光度，t表示时间，*表示表示乘法的符号，我们有函数x = a0 + a1 * exp（-k1 * t）+ a2 * exp（-k2 * t）。 计算参数a0，a1，a2，ai，k1和k2的值，使得使用上述表达式计算的测量时间的吸光度与时间序列数据之间的差异最小，并且基于 对参数值。
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