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公开(公告)号:US5380934A
公开(公告)日:1995-01-10
申请号:US141622
申请日:1993-10-27
申请人: Kunimi Inoue , Yoshiyuki Yamada , Kazumi Amatsu , Yukiteru Mimura , Yasunori Nakaguchi , Hiroyuki Shinmura , Yasuyuki Ono , Yutaka Osawa , Shoichi Mizutaki , Masaji Kasai , Shinji Tomioka
发明人: Kunimi Inoue , Yoshiyuki Yamada , Kazumi Amatsu , Yukiteru Mimura , Yasunori Nakaguchi , Hiroyuki Shinmura , Yasuyuki Ono , Yutaka Osawa , Shoichi Mizutaki , Masaji Kasai , Shinji Tomioka
IPC分类号: C07C237/22 , C07C309/66 , C07C309/73 , C07K5/06 , C07C229/00
CPC分类号: C07C309/66 , C07C237/22 , C07C309/73 , C07K5/06026
摘要: Disclosed is a process for producing alanylglutamine, which comprises reacting an N-(2-substituted)-propionylglutamine compound represented by the formula (I): ##STR1## where X represents halogen, alkylsulfonyloxy, or substituted or unsubstituted arylsulfonyloxy, with ammonia at a temperature of 60.degree. C. or below.In accordance with the present invention, highly purified alanylglutamine can be produced in a high yield, without racemization.
摘要翻译: 公开了一种生产丙氨酰谷氨酰胺的方法,其包括使式(I)表示的N-(2-取代的) - 丙酰基谷氨酰胺化合物:其中X表示卤素,烷基磺酰氧基或取代或未取代的芳基磺酰氧基与式 温度在60℃以下的氨。 根据本发明,可以以高产率生产高度纯化的丙氨基谷氨酰胺,而不需外消旋化。
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公开(公告)号:US5550283A
公开(公告)日:1996-08-27
申请号:US307417
申请日:1994-09-19
申请人: Kunimi Inoue , Yoshiyuki Yamada , Kazumi Amatsu , Yukiteru Mimura , Yasunori Nakaguchi , Hiroyuki Shinmura , Yasuyuki Ono , Yutaka Osawa , Shoichi Mizutaki , Masaji Kasai , Shinji Tomioka
发明人: Kunimi Inoue , Yoshiyuki Yamada , Kazumi Amatsu , Yukiteru Mimura , Yasunori Nakaguchi , Hiroyuki Shinmura , Yasuyuki Ono , Yutaka Osawa , Shoichi Mizutaki , Masaji Kasai , Shinji Tomioka
IPC分类号: C07C237/22 , C07C309/66 , C07C309/73 , C07K5/06 , C07C229/00
CPC分类号: C07C309/66 , C07C237/22 , C07C309/73 , C07K5/06026
摘要: Disclosed is a process for producing alanylglutamine, which comprises reacting an N-(2-substituted)-propionylglutamine compound represented by the formula (I): ##STR1## where X represents halogen, alkylsulfonyloxy, or substituted or unsubstituted arylsulfonyloxy, with ammonia at a temperature of 60.degree. C. or below.in accordance with the present invention, highly purified alanylglutamine can be produced in a high yield, without racemization.
摘要翻译: 公开了一种生产丙氨酰谷氨酰胺的方法,其包括使式(I)表示的N-(2-取代的) - 丙酰基谷氨酰胺化合物:其中X表示卤素,烷基磺酰氧基或取代或未取代的芳基磺酰氧基与式 温度在60℃以下的氨。 根据本发明,可以以高产率制备高度纯化的丙氨基谷氨酰胺,而不进行外消旋化。
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