公开(公告)号：US20120225866A1

公开(公告)日：2012-09-06

申请号：US13388442

申请日：2010-08-20

申请人： Kunio Oshima ,  Shuuji Matsumura ,  Hokuto Yamabe ,  Naohiro Isono ,  Noriaki Takemura ,  Shinichi Taira ,  Takashi Oshiyama ,  Yasuhiro Menjo ,  Tsuyoshi Nagase ,  Masataka Ueda ,  Yasuo Koga ,  Sunao Nakayama ,  Kenji Tsujimae ,  Toshiyuki Onogawa ,  Kuninori Tai ,  Motohiro Itotani

发明人： Kunio Oshima ,  Shuuji Matsumura ,  Hokuto Yamabe ,  Naohiro Isono ,  Noriaki Takemura ,  Shinichi Taira ,  Takashi Oshiyama ,  Yasuhiro Menjo ,  Tsuyoshi Nagase ,  Masataka Ueda ,  Yasuo Koga ,  Sunao Nakayama ,  Kenji Tsujimae ,  Toshiyuki Onogawa ,  Kuninori Tai ,  Motohiro Itotani

IPC分类号： A61K31/5513 ,  C07D493/10 ,  A61P9/06 ,  C07D243/14

CPC分类号： C07D491/048 ,  C07D213/38 ,  C07D215/227 ,  C07D243/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

摘要： The present invention provides a novel diazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R1, R2, R3, and R4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y1 and Y2 are each independently —N═ or —CH═; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; R6 and R7 may be linked to form a ring together with the neighboring group —XA—N—XB—; XA and XB are each independently a bond, lower alkylene, etc.

摘要翻译： 本发明提供了一种新颖的二氮杂类化合物，其比其他K +通道有效地和选择性地阻断IK电流或Kv1.5通道。 本发明涉及由通式（1）表示的二氮杂化合物或其盐，其中R 1，R 2，R 3和R 4各自独立地为氢，低级烷基，环低级烷基或低级烷氧基低级烷基; R2和R3可以连接形成低级亚烷基; A1是任选被一个或多个选自羟基和氧代的取代基取代的低级亚烷基; Y1和Y2各自独立地为-N =或-CH =; 并且R 5为其中R 6和R 7各自独立地为氢或有机基团的基团; R6和R7可以与相邻基团-XA-N-XB-一起形成环; XA和XB各自独立地为键，低级亚烷基等

公开(公告)号：US20130040941A1

公开(公告)日：2013-02-14

申请号：US13591361

申请日：2012-08-22

申请人： Kunio Oshima ,  Takashi Oshiyama ,  Shinichi Taira ,  Yasuhiro Menjo ,  Hokuto Yamabe ,  Shuuji Matsumura ,  Masataka Ueda ,  Yasuo Koga ,  Kuninori Tai ,  Sunao Nakayama ,  Toshiyuki Onogawa ,  Kenji Tsujimae

发明人： Kunio Oshima ,  Takashi Oshiyama ,  Shinichi Taira ,  Yasuhiro Menjo ,  Hokuto Yamabe ,  Shuuji Matsumura ,  Masataka Ueda ,  Yasuo Koga ,  Kuninori Tai ,  Sunao Nakayama ,  Toshiyuki Onogawa ,  Kenji Tsujimae

IPC分类号： A61K31/551 ,  C07D243/12 ,  C07D491/048 ,  C07D409/14 ,  C07D495/04 ,  A61P9/06 ,  C07D405/14 ,  C07D413/14 ,  C07D401/12 ,  C07D471/04 ,  C07D513/04 ,  C07D417/14 ,  C07D403/12 ,  C07D401/14

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

摘要： The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.

摘要翻译： 本发明提供了一种新颖的苯并二氮杂化合物，其比其他K +通道有效地和更有选择地阻断IK电流或Kv1.5通道。 本发明的苯并二氮杂化合物由通式（1）表示，其中R 1，R 2，R 3和R 4各自独立地为氢或低级烷基; R2和R3可以连接形成低级亚烷基; A1是任选被一个或多个羟基取代的低级亚烷基; 并且R 5为其中R 6和R 7各自独立地为氢或有机基团的基团; XA和XB各自独立地键合，低级亚烷基等。

公开(公告)号：US08338406B2

公开(公告)日：2012-12-25

申请号：US12918226

申请日：2009-02-20

申请人： Kunio Oshima ,  Takashi Oshiyama ,  Shinichi Taira ,  Yasuhiro Menjo ,  Hokuto Yamabe ,  Shuuji Matsumura ,  Masataka Ueda ,  Yasuo Koga ,  Kuninori Tai ,  Sunao Nakayama ,  Toshiyuki Onogawa ,  Kenji Tsujimae

发明人： Kunio Oshima ,  Takashi Oshiyama ,  Shinichi Taira ,  Yasuhiro Menjo ,  Hokuto Yamabe ,  Shuuji Matsumura ,  Masataka Ueda ,  Yasuo Koga ,  Kuninori Tai ,  Sunao Nakayama ,  Toshiyuki Onogawa ,  Kenji Tsujimae

IPC分类号： C07D243/12 ,  C07D401/12 ,  C07D401/14 ,  C07D491/04 ,  C07D405/14 ,  C07D417/14 ,  A61K31/551 ,  A61P9/06

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

摘要： The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.

摘要翻译： 本发明提供了一种新颖的苯并二氮杂化合物，其比其他K +通道有效地和更有选择地阻断IK电流或Kv1.5通道。 本发明的苯并二氮杂化合物由通式（1）表示，其中R 1，R 2，R 3和R 4各自独立地为氢或低级烷基; R2和R3可以连接形成低级亚烷基; A1是任选被一个或多个羟基取代的低级亚烷基; 并且R 5为其中R 6和R 7各自独立地为氢或有机基团的基团; XA和XB各自独立地键合，低级亚烷基等。

公开(公告)号：US20100331317A1

公开(公告)日：2010-12-30

申请号：US12918226

申请日：2009-02-20

申请人： Kunio Oshima ,  Takashi Oshiyama ,  Shinichi Taira ,  Yasuhiro Menjo ,  Hokuto Yamabe ,  Shuuji Matsumura ,  Masataka Ueda ,  Yasuo Koga ,  Kuninori Tai ,  Sunao Nakayama ,  Toshiyuki Onogawa ,  Kenji Tsujimae

发明人： Kunio Oshima ,  Takashi Oshiyama ,  Shinichi Taira ,  Yasuhiro Menjo ,  Hokuto Yamabe ,  Shuuji Matsumura ,  Masataka Ueda ,  Yasuo Koga ,  Kuninori Tai ,  Sunao Nakayama ,  Toshiyuki Onogawa ,  Kenji Tsujimae

IPC分类号： A61K31/551 ,  C07D243/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  A61P9/06

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

摘要： The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.

摘要翻译： 本发明提供了一种新颖的苯并二氮杂化合物，其比其他K +通道有效地和更有选择地阻断IKur电流或Kv1.5通道。 本发明的苯并二氮杂化合物由通式（1）表示，其中R 1，R 2，R 3和R 4各自独立地为氢或低级烷基; R2和R3可以连接形成低级亚烷基; A1是任选被一个或多个羟基取代的低级亚烷基; 并且R 5为其中R 6和R 7各自独立地为氢或有机基团的基团; XA和XB各自独立地键合，低级亚烷基等。

公开(公告)号：US08664217B2

公开(公告)日：2014-03-04

申请号：US13591361

申请日：2012-08-22

申请人： Kunio Oshima ,  Takashi Oshiyama ,  Shinichi Taira ,  Yasuhiro Menjo ,  Hokuto Yamabe ,  Shuuji Matsumura ,  Masataka Ueda ,  Yasuo Koga ,  Kuninori Tai ,  Sunao Nakayama ,  Toshiyuki Onogawa ,  Kenji Tsujimae

发明人： Kunio Oshima ,  Takashi Oshiyama ,  Shinichi Taira ,  Yasuhiro Menjo ,  Hokuto Yamabe ,  Shuuji Matsumura ,  Masataka Ueda ,  Yasuo Koga ,  Kuninori Tai ,  Sunao Nakayama ,  Toshiyuki Onogawa ,  Kenji Tsujimae

IPC分类号： C07D243/12 ,  C07D401/12 ,  C07D401/14 ,  C07D491/04 ,  C07D405/14 ,  C07D417/14

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

摘要： The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; Al is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.

摘要翻译： 本发明提供了一种新颖的苯并二氮杂化合物，其比其他K +通道有效地和更有选择地阻断IK电流或Kv1.5通道。 本发明的苯并二氮杂化合物由通式（1）表示，其中R 1，R 2，R 3和R 4各自独立地为氢或低级烷基; R2和R3可以连接形成低级亚烷基; Al是任选被一个或多个羟基取代的低级亚烷基; 并且R 5为其中R 6和R 7各自独立地为氢或有机基团的基团; XA和XB各自独立地键合，低级亚烷基等。

公开(公告)号：US08822453B2

公开(公告)日：2014-09-02

申请号：US13388442

申请日：2010-08-20

申请人： Shuuji Matsumura ,  Hokuto Yamabe ,  Naohiro Isono ,  Noriaki Takemura ,  Takashi Oshiyama ,  Tsuyoshi Nagase ,  Masataka Ueda ,  Kuninori Tai

发明人： Shuuji Matsumura ,  Hokuto Yamabe ,  Naohiro Isono ,  Noriaki Takemura ,  Takashi Oshiyama ,  Tsuyoshi Nagase ,  Masataka Ueda ,  Kuninori Tai

IPC分类号： C07D243/12 ,  C07D409/12 ,  C07D495/04 ,  A61K31/551 ,  A61K31/4985 ,  A61P9/06 ,  C07D401/14 ,  C07D471/04 ,  C07D403/12 ,  C07D403/14 ,  C07D401/12

CPC分类号： C07D491/048 ,  C07D213/38 ,  C07D215/227 ,  C07D243/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

摘要： The present invention provides a novel diazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R1, R2, R3, and R4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y1 and Y2 are each independently —N═ or —CH═; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; R6 and R7 may be linked to form a ring together with the neighboring group —XA—N—XB—; XA and XB are each independently a bond, lower alkylene, etc.

摘要翻译： 本发明提供了一种新颖的二氮杂类化合物，其比其他K +通道有效地和选择性地阻断IK电流或Kv1.5通道。 本发明涉及由通式（1）表示的二氮杂化合物或其盐，其中R 1，R 2，R 3和R 4各自独立地为氢，低级烷基，环低级烷基或低级烷氧基低级烷基; R2和R3可以连接形成低级亚烷基; A1是任选被一个或多个选自羟基和氧代的取代基取代的低级亚烷基; Y1和Y2各自独立地为-N =或-CH =; 并且R 5为其中R 6和R 7各自独立地为氢或有机基团的基团; R6和R7可以与相邻基团-XA-N-XB-一起形成环; XA和XB各自独立地为键，低级亚烷基等

公开(公告)号：US06890381B2

公开(公告)日：2005-05-10

申请号：US10258928

申请日：2001-04-27

申请人： Satoshi Ozawa ,  Eishi Fukuda ,  Shuuji Matsumura

发明人： Satoshi Ozawa ,  Eishi Fukuda ,  Shuuji Matsumura

IPC分类号： H01F1/055 ,  H01F1/08 ,  H01F41/02 ,  H01F1/04

CPC分类号： H01F41/0253 ,  H01F1/0558 ,  H01F1/083

摘要： An object of the present invention is to provide a hydraulic-composition bonded magnet having moldability, heat resistance, corrosion resistance and high strength.A hydraulic-composition bonded magnet according to the present invention is characterized by that a magnetic powder is held in a hydraulic composition produced by cure of a hydraulic powder. Preferably, in the hydraulic-composition bonded magnet, the hydraulic composition is cured together with a non-hydraulic powder. More preferably, a processing modifier is added to the hydraulic-composition bonded magnet.

摘要翻译： 本发明的目的是提供一种具有成型性，耐热性，耐腐蚀性和高强度的水硬性组合物粘结磁体。 根据本发明的水硬性粘结磁体的特征在于，磁性粉末保持在通过水硬性粉末固化而制成的水硬性组合物中。 优选地，在水硬性组合物粘结磁体中，水硬性组合物与非水硬性粉末一起固化。 更优选地，将加工改性剂加入到水硬性组合物粘结磁体中。

公开(公告)号：US07329196B2

公开(公告)日：2008-02-12

申请号：US10950997

申请日：2004-09-27

申请人： Masahiko Konno ,  Shuuji Matsumura

发明人： Masahiko Konno ,  Shuuji Matsumura

IPC分类号： F16H7/08 ,  F16H7/18

CPC分类号： F16H7/18 ,  F16H2007/0872

摘要： In a guide for a transmission chain, a slide rail elongated in the direction of travel of the chain, and having a front surface for sliding engagement with the chain, is supported by a rail support which extends perpendicularly from the back side of the slide rail. The guide is formed by sandwich molding and comprises a glass fiber-reinforced polymer resin forming a core of the rail support, and a wear-resistant polymer resin forming both the slide rail, and a skin layer on the rail support, the skin layer of the rail support being unitary with the slide rail. A plurality of hollow, heat-dissipating, cavities extend inwardly from both sides of the slide rail in directions transverse to the direction of elongation of the slide rail.

摘要翻译： 在用于传动链的引导件中，沿着链的行进方向延伸并且具有用于与链条滑动接合的前表面的滑轨由从轨道的后侧垂直延伸的轨道支撑件支撑， 。 引导件通过夹层成型形成，并且包括形成轨道支撑件的芯部的玻璃纤维增​​强聚合物树脂和形成滑轨的耐磨聚合物树脂和轨道支撑件上的表层， 轨道支架与滑轨一体。 多个中空的散热腔从与滑轨延伸方向相垂直的方向从滑轨的两侧向内延伸。

公开(公告)号：US20050107196A1

公开(公告)日：2005-05-19

申请号：US10950997

申请日：2004-09-27

申请人： Masahiko Konno ,  Shuuji Matsumura

发明人： Masahiko Konno ,  Shuuji Matsumura

IPC分类号： F16H7/08 ,  F16H7/18 ,  F16H57/035

CPC分类号： F16H7/18 ,  F16H2007/0872

摘要： In a guide for a transmission chain, a slide rail elongated in the direction of travel of the chain, and having a front surface for sliding engagement with the chain, is supported by a rail support which extends perpendicularly from the back side of the slide rail. The guide is formed by sandwich molding and comprises a glass fiber-reinforced polymer resin forming a core of the rail support, and a wear-resistant polymer resin forming both the slide rail, and a skin layer on the rail support, the skin layer of the rail support being unitary with the slide rail. A plurality of hollow, heat-dissipating, cavities extend inwardly from both sides of the slide rail in directions transverse to the direction of elongation of the slide rail.

摘要翻译： 在用于传动链的引导件中，沿着链的行进方向延伸并且具有用于与链条滑动接合的前表面的滑轨由从轨道的后侧垂直延伸的轨道支撑件支撑， 。 引导件通过夹层成型形成，并且包括形成轨道支撑件的芯部的玻璃纤维增​​强聚合物树脂和形成滑轨的耐磨聚合物树脂和轨道支撑件上的表层， 轨道支架与滑轨一体。 多个中空的散热腔从与滑轨延伸方向相垂直的方向从滑轨的两侧向内延伸。

公开(公告)号：US06890277B2

公开(公告)日：2005-05-10

申请号：US10167345

申请日：2002-06-10

申请人： Kozo Inoue ,  Osamu Ono ,  Shuuji Matsumura ,  Koji Yamawaki

发明人： Kozo Inoue ,  Osamu Ono ,  Shuuji Matsumura ,  Koji Yamawaki

IPC分类号： F16H7/08 ,  B29C45/00 ,  F16H7/18

CPC分类号： F16H7/18 ,  B29C45/00 ,  F16H2007/0872

摘要： A guide for as transmission device such as a chain or belt, is injection molded using a sandwich-molding process. The sandwhich-molded guide comprises a slide rail on which a chain or belt slides, and a rail supporting member intergrally provided along with the slide rail. The slide rail is composed of a material the principle component of which is first polymeric material having wear resistance and heat resistance, and the rail supporting member is composed of a material the principle component of which is a second polymeric material having higher strength than the material having the first polymeric material as its principle component. The slide rail and the rail supporting member are intimately joined to each other by injection molding using the sandwhich molding process.

摘要翻译： 作为传动装置如链条或皮带的引导件使用三明治模制工艺进行注射成型。 砂形模制导轨包括滑轨，链条或皮带滑动在该滑轨上，轨道支撑构件与滑轨一体地设置。 滑轨由材料构成，其主要成分是具有耐磨性和耐热性的第一种聚合材料，并且轨道支撑构件由其主要成分是具有比材料更高强度的第二聚合材料的材料组成 具有第一种聚合物材料作为其主要组分。 滑轨和轨道支撑构件通过使用砂成型工艺的注射成型彼此紧密地接合。