公开(公告)号：US20120225866A1

公开(公告)日：2012-09-06

申请号：US13388442

申请日：2010-08-20

申请人： Kunio Oshima ,  Shuuji Matsumura ,  Hokuto Yamabe ,  Naohiro Isono ,  Noriaki Takemura ,  Shinichi Taira ,  Takashi Oshiyama ,  Yasuhiro Menjo ,  Tsuyoshi Nagase ,  Masataka Ueda ,  Yasuo Koga ,  Sunao Nakayama ,  Kenji Tsujimae ,  Toshiyuki Onogawa ,  Kuninori Tai ,  Motohiro Itotani

发明人： Kunio Oshima ,  Shuuji Matsumura ,  Hokuto Yamabe ,  Naohiro Isono ,  Noriaki Takemura ,  Shinichi Taira ,  Takashi Oshiyama ,  Yasuhiro Menjo ,  Tsuyoshi Nagase ,  Masataka Ueda ,  Yasuo Koga ,  Sunao Nakayama ,  Kenji Tsujimae ,  Toshiyuki Onogawa ,  Kuninori Tai ,  Motohiro Itotani

IPC分类号： A61K31/5513 ,  C07D493/10 ,  A61P9/06 ,  C07D243/14

CPC分类号： C07D491/048 ,  C07D213/38 ,  C07D215/227 ,  C07D243/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

摘要： The present invention provides a novel diazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R1, R2, R3, and R4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y1 and Y2 are each independently —N═ or —CH═; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; R6 and R7 may be linked to form a ring together with the neighboring group —XA—N—XB—; XA and XB are each independently a bond, lower alkylene, etc.

摘要翻译： 本发明提供了一种新颖的二氮杂类化合物，其比其他K +通道有效地和选择性地阻断IK电流或Kv1.5通道。 本发明涉及由通式（1）表示的二氮杂化合物或其盐，其中R 1，R 2，R 3和R 4各自独立地为氢，低级烷基，环低级烷基或低级烷氧基低级烷基; R2和R3可以连接形成低级亚烷基; A1是任选被一个或多个选自羟基和氧代的取代基取代的低级亚烷基; Y1和Y2各自独立地为-N =或-CH =; 并且R 5为其中R 6和R 7各自独立地为氢或有机基团的基团; R6和R7可以与相邻基团-XA-N-XB-一起形成环; XA和XB各自独立地为键，低级亚烷基等

公开(公告)号：US08664217B2

公开(公告)日：2014-03-04

申请号：US13591361

申请日：2012-08-22

申请人： Kunio Oshima ,  Takashi Oshiyama ,  Shinichi Taira ,  Yasuhiro Menjo ,  Hokuto Yamabe ,  Shuuji Matsumura ,  Masataka Ueda ,  Yasuo Koga ,  Kuninori Tai ,  Sunao Nakayama ,  Toshiyuki Onogawa ,  Kenji Tsujimae

发明人： Kunio Oshima ,  Takashi Oshiyama ,  Shinichi Taira ,  Yasuhiro Menjo ,  Hokuto Yamabe ,  Shuuji Matsumura ,  Masataka Ueda ,  Yasuo Koga ,  Kuninori Tai ,  Sunao Nakayama ,  Toshiyuki Onogawa ,  Kenji Tsujimae

IPC分类号： C07D243/12 ,  C07D401/12 ,  C07D401/14 ,  C07D491/04 ,  C07D405/14 ,  C07D417/14

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

摘要： The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; Al is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.

摘要翻译： 本发明提供了一种新颖的苯并二氮杂化合物，其比其他K +通道有效地和更有选择地阻断IK电流或Kv1.5通道。 本发明的苯并二氮杂化合物由通式（1）表示，其中R 1，R 2，R 3和R 4各自独立地为氢或低级烷基; R2和R3可以连接形成低级亚烷基; Al是任选被一个或多个羟基取代的低级亚烷基; 并且R 5为其中R 6和R 7各自独立地为氢或有机基团的基团; XA和XB各自独立地键合，低级亚烷基等。

公开(公告)号：US20130040941A1

公开(公告)日：2013-02-14

申请号：US13591361

申请日：2012-08-22

申请人： Kunio Oshima ,  Takashi Oshiyama ,  Shinichi Taira ,  Yasuhiro Menjo ,  Hokuto Yamabe ,  Shuuji Matsumura ,  Masataka Ueda ,  Yasuo Koga ,  Kuninori Tai ,  Sunao Nakayama ,  Toshiyuki Onogawa ,  Kenji Tsujimae

发明人： Kunio Oshima ,  Takashi Oshiyama ,  Shinichi Taira ,  Yasuhiro Menjo ,  Hokuto Yamabe ,  Shuuji Matsumura ,  Masataka Ueda ,  Yasuo Koga ,  Kuninori Tai ,  Sunao Nakayama ,  Toshiyuki Onogawa ,  Kenji Tsujimae

IPC分类号： A61K31/551 ,  C07D243/12 ,  C07D491/048 ,  C07D409/14 ,  C07D495/04 ,  A61P9/06 ,  C07D405/14 ,  C07D413/14 ,  C07D401/12 ,  C07D471/04 ,  C07D513/04 ,  C07D417/14 ,  C07D403/12 ,  C07D401/14

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

摘要： The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.

摘要翻译： 本发明提供了一种新颖的苯并二氮杂化合物，其比其他K +通道有效地和更有选择地阻断IK电流或Kv1.5通道。 本发明的苯并二氮杂化合物由通式（1）表示，其中R 1，R 2，R 3和R 4各自独立地为氢或低级烷基; R2和R3可以连接形成低级亚烷基; A1是任选被一个或多个羟基取代的低级亚烷基; 并且R 5为其中R 6和R 7各自独立地为氢或有机基团的基团; XA和XB各自独立地键合，低级亚烷基等。

公开(公告)号：US08338406B2

公开(公告)日：2012-12-25

申请号：US12918226

申请日：2009-02-20

申请人： Kunio Oshima ,  Takashi Oshiyama ,  Shinichi Taira ,  Yasuhiro Menjo ,  Hokuto Yamabe ,  Shuuji Matsumura ,  Masataka Ueda ,  Yasuo Koga ,  Kuninori Tai ,  Sunao Nakayama ,  Toshiyuki Onogawa ,  Kenji Tsujimae

发明人： Kunio Oshima ,  Takashi Oshiyama ,  Shinichi Taira ,  Yasuhiro Menjo ,  Hokuto Yamabe ,  Shuuji Matsumura ,  Masataka Ueda ,  Yasuo Koga ,  Kuninori Tai ,  Sunao Nakayama ,  Toshiyuki Onogawa ,  Kenji Tsujimae

IPC分类号： C07D243/12 ,  C07D401/12 ,  C07D401/14 ,  C07D491/04 ,  C07D405/14 ,  C07D417/14 ,  A61K31/551 ,  A61P9/06

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

摘要： The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.

摘要翻译： 本发明提供了一种新颖的苯并二氮杂化合物，其比其他K +通道有效地和更有选择地阻断IK电流或Kv1.5通道。 本发明的苯并二氮杂化合物由通式（1）表示，其中R 1，R 2，R 3和R 4各自独立地为氢或低级烷基; R2和R3可以连接形成低级亚烷基; A1是任选被一个或多个羟基取代的低级亚烷基; 并且R 5为其中R 6和R 7各自独立地为氢或有机基团的基团; XA和XB各自独立地键合，低级亚烷基等。

公开(公告)号：US20100331317A1

公开(公告)日：2010-12-30

申请号：US12918226

申请日：2009-02-20

申请人： Kunio Oshima ,  Takashi Oshiyama ,  Shinichi Taira ,  Yasuhiro Menjo ,  Hokuto Yamabe ,  Shuuji Matsumura ,  Masataka Ueda ,  Yasuo Koga ,  Kuninori Tai ,  Sunao Nakayama ,  Toshiyuki Onogawa ,  Kenji Tsujimae

发明人： Kunio Oshima ,  Takashi Oshiyama ,  Shinichi Taira ,  Yasuhiro Menjo ,  Hokuto Yamabe ,  Shuuji Matsumura ,  Masataka Ueda ,  Yasuo Koga ,  Kuninori Tai ,  Sunao Nakayama ,  Toshiyuki Onogawa ,  Kenji Tsujimae

IPC分类号： A61K31/551 ,  C07D243/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  A61P9/06

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

摘要： The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.

摘要翻译： 本发明提供了一种新颖的苯并二氮杂化合物，其比其他K +通道有效地和更有选择地阻断IKur电流或Kv1.5通道。 本发明的苯并二氮杂化合物由通式（1）表示，其中R 1，R 2，R 3和R 4各自独立地为氢或低级烷基; R2和R3可以连接形成低级亚烷基; A1是任选被一个或多个羟基取代的低级亚烷基; 并且R 5为其中R 6和R 7各自独立地为氢或有机基团的基团; XA和XB各自独立地键合，低级亚烷基等。

公开(公告)号：US08822453B2

公开(公告)日：2014-09-02

申请号：US13388442

申请日：2010-08-20

申请人： Shuuji Matsumura ,  Hokuto Yamabe ,  Naohiro Isono ,  Noriaki Takemura ,  Takashi Oshiyama ,  Tsuyoshi Nagase ,  Masataka Ueda ,  Kuninori Tai

发明人： Shuuji Matsumura ,  Hokuto Yamabe ,  Naohiro Isono ,  Noriaki Takemura ,  Takashi Oshiyama ,  Tsuyoshi Nagase ,  Masataka Ueda ,  Kuninori Tai

IPC分类号： C07D243/12 ,  C07D409/12 ,  C07D495/04 ,  A61K31/551 ,  A61K31/4985 ,  A61P9/06 ,  C07D401/14 ,  C07D471/04 ,  C07D403/12 ,  C07D403/14 ,  C07D401/12

CPC分类号： C07D491/048 ,  C07D213/38 ,  C07D215/227 ,  C07D243/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

摘要： The present invention provides a novel diazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R1, R2, R3, and R4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y1 and Y2 are each independently —N═ or —CH═; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; R6 and R7 may be linked to form a ring together with the neighboring group —XA—N—XB—; XA and XB are each independently a bond, lower alkylene, etc.

摘要翻译： 本发明提供了一种新颖的二氮杂类化合物，其比其他K +通道有效地和选择性地阻断IK电流或Kv1.5通道。 本发明涉及由通式（1）表示的二氮杂化合物或其盐，其中R 1，R 2，R 3和R 4各自独立地为氢，低级烷基，环低级烷基或低级烷氧基低级烷基; R2和R3可以连接形成低级亚烷基; A1是任选被一个或多个选自羟基和氧代的取代基取代的低级亚烷基; Y1和Y2各自独立地为-N =或-CH =; 并且R 5为其中R 6和R 7各自独立地为氢或有机基团的基团; R6和R7可以与相邻基团-XA-N-XB-一起形成环; XA和XB各自独立地为键，低级亚烷基等

公开(公告)号：US4888658A

公开(公告)日：1989-12-19

申请号：US175605

申请日：1988-04-01

申请人： Mitsuaki Ono ,  Masataka Ueda ,  Osamu Miyazaki

发明人： Mitsuaki Ono ,  Masataka Ueda ,  Osamu Miyazaki

IPC分类号： G11B5/187

CPC分类号： G11B5/1871 ,  Y10T29/49043 ,  Y10T29/49052 ,  Y10T29/49057 ,  Y10T29/49067

摘要： In a magnetic head comprising a head gap and a magnetic core composed of both a high permeability ferrite and a magnetic alloy, said magnetic alloy being disposed in the vicinity of said head gap,the improvement comprising a corrugation provided at a junction portion between said ferrite and said magnetic alloy, a height of said corrugation being not less than a value of the longest wavelength of luminance signals and color signals recorded on a magnetic recording medium, a distance defined between adjacent two crests or bottoms of said corrugation being smaller than a width of a head track.

公开(公告)号：US4769898A

公开(公告)日：1988-09-13

申请号：US041283

申请日：1987-04-22

申请人： Mitsuaki Ono ,  Masataka Ueda ,  Osamu Miyazaki

发明人： Mitsuaki Ono ,  Masataka Ueda ,  Osamu Miyazaki

IPC分类号： G11B5/187 ,  G11B5/42

CPC分类号： G11B5/1871 ,  Y10T29/49043 ,  Y10T29/49052 ,  Y10T29/49057 ,  Y10T29/49067

摘要： In a magnetic head comprising a head gap and a magnetic core composed of both a high permeability ferrite and a magnetic alloy, said magnetic alloy being disposed in the vicinity of said head gap,the improvement comprising a corrugation provided at a junction portion between said ferrite and said magnetic alloy, a height of said corrugation being not less than a value of the longest wavelength of luminance signals and color signals recorded on a magnetic recording medium, a distance defined between adjacent two crests or bottoms of said corrugation being smaller than a width of a head track.

摘要翻译： 在包括头部间隙的磁头和由高磁导率铁氧体和磁性合金构成的磁芯中，所述磁性合金设置在所述磁头间隙附近，该改进包括设置在所述铁氧体 和所述磁性合金，所述波纹的高度不小于记录在磁记录介质上的亮度信号和颜色信号的最长波长的值，所述波纹的相邻两个波峰或底部之间限定的距离小于宽度 的头轨。