Synthetic antibody phage libraries
    7.
    发明授权
    Synthetic antibody phage libraries 有权
    合成抗体噬菌体文库

    公开(公告)号:US07985840B2

    公开(公告)日:2011-07-26

    申请号:US10939309

    申请日:2004-09-09

    IPC分类号: C07K16/00 G01N33/53

    摘要: The invention provides comprising variant amino acids in CDRs of antibody variable domains. These polypeptides provide a source of great sequence diversity that can be used as a source for identifying novel antigen binding polypeptides. The invention also provides these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags, and linkers. Libraries comprising a plurality of these polypeptides are also provided. In addition, methods of and compositions for generating and using these polypeptides and libraries are provided.

    摘要翻译: 本发明提供包含抗体可变结构域的CDR中的变体氨基酸。 这些多肽提供了可用作识别新型抗原结合多肽的来源的伟大序列多样性的来源。 本发明还提供这些多肽作为异源多肽的融合多肽,例如噬菌体或病毒外壳蛋白,标签和接头的至少一部分。 还提供了包含多个这些多肽的文库。 此外,提供了用于产生和使用这些多肽和文库的方法和组合物。