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公开(公告)号:US07977064B2
公开(公告)日:2011-07-12
申请号:US12696875
申请日:2010-01-29
申请人: Yingnan Zhang , Mike Costa , Sachdev S. Sidhu
发明人: Yingnan Zhang , Mike Costa , Sachdev S. Sidhu
CPC分类号: G01N33/57496 , C07K7/06 , C07K2319/01 , G01N2500/02
摘要: The invention provides modulators of Dvl PDZ-ligand interaction, and methods of identifying and using these modulators.
摘要翻译: 本发明提供Dvl PDZ-配体相互作用的调节剂,以及鉴定和使用这些调节剂的方法。
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公开(公告)号:US20080167386A1
公开(公告)日:2008-07-10
申请号:US11733146
申请日:2007-04-09
申请人: Yingnan Zhang , Mike Costa , Sachdev S. Sidhu
发明人: Yingnan Zhang , Mike Costa , Sachdev S. Sidhu
CPC分类号: G01N33/57496 , C07K7/06 , C07K2319/01 , G01N2500/02
摘要: The invention provides modulators of Dvl PDZ-ligand interaction, and methods of identifying and using these modulators.
摘要翻译: 本发明提供Dvl PDZ-配体相互作用的调节剂,以及鉴定和使用这些调节剂的方法。
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公开(公告)号:US20100136580A1
公开(公告)日:2010-06-03
申请号:US12696875
申请日:2010-01-29
申请人: Yingnan Zhang , Mike Costa , Sachdev S. Sidhu
发明人: Yingnan Zhang , Mike Costa , Sachdev S. Sidhu
CPC分类号: G01N33/57496 , C07K7/06 , C07K2319/01 , G01N2500/02
摘要: The invention provides modulators of Dvl PDZ-ligand interaction, and methods of identifying and using these modulators.
摘要翻译: 本发明提供Dvl PDZ-配体相互作用的调节剂,以及鉴定和使用这些调节剂的方法。
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公开(公告)号:US07695928B2
公开(公告)日:2010-04-13
申请号:US11733146
申请日:2007-04-09
申请人: Yingnan Zhang , Mike Costa , Sachdev S. Sidhu
发明人: Yingnan Zhang , Mike Costa , Sachdev S. Sidhu
CPC分类号: G01N33/57496 , C07K7/06 , C07K2319/01 , G01N2500/02
摘要: The invention provides modulators of Dvl PDZ-ligand interaction, and methods of identifying and using these modulators.
摘要翻译: 本发明提供Dvl PDZ-配体相互作用的调节剂,以及鉴定和使用这些调节剂的方法。
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公开(公告)号:US20110256127A1
公开(公告)日:2011-10-20
申请号:US13069582
申请日:2011-03-23
申请人: Eric Bourhis , Tim Cao , Rick Carano , Andrea Cochran , Mike Costa , Venita DeAlmeida , James Ernst , Yan Gong , Rami Hannoush , Paul Polakis , Bonnee Rubinfeld , Mark Solloway , Yan Wu
发明人: Eric Bourhis , Tim Cao , Rick Carano , Andrea Cochran , Mike Costa , Venita DeAlmeida , James Ernst , Yan Gong , Rami Hannoush , Paul Polakis , Bonnee Rubinfeld , Mark Solloway , Yan Wu
CPC分类号: C07K16/28 , A61K39/3955 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/526 , C07K2317/55 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要: The invention provides anti-LRP6 antibodies and methods of using the same. A particular aspect of the invention provides for bispecific anti-LRP6 antibodies that inhibit signaling by multiple Wnt isoforms.
摘要翻译: 本发明提供抗LRP6抗体及其使用方法。 本发明的一个特定方面提供了抑制多种Wnt同种型的信号通路的双特异性抗LRP6抗体。
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公开(公告)号:US07712296B2
公开(公告)日:2010-05-11
申请号:US11195401
申请日:2005-08-01
申请人: Mike Costa , Peter DeGroot
发明人: Mike Costa , Peter DeGroot
IPC分类号: A01D45/00
CPC分类号: A01D45/263
摘要: An apparatus that moves through fields of leafy vegetables and trims harvested heads of leafy vegetables. The apparatus includes a body and a plurality of supports coupled to the body for movement relative thereto. The supports are configured for supporting pieces of leafy vegetables. The apparatus further includes a plurality of cutters coupled to the body that are arranged serially and a transport system for moving the supports past the cutters. A collector is included for collecting leaves cut from the vegetables.
摘要翻译: 一种通过绿叶蔬菜的田地移动的装置,修剪了叶菜类的收割头。 该装置包括主体和联接到主体的多个支撑件,用于相对于其移动。 支撑件被配置为支撑叶菜类蔬菜。 该装置还包括连接到主体的多个切割器,其连续布置,以及用于使支撑件移动通过切割器的传送系统。 收集收集器用于收集从蔬菜切下的叶子。
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公开(公告)号:US08846041B2
公开(公告)日:2014-09-30
申请号:US13069582
申请日:2011-03-23
申请人: Eric Bourhis , Tim Cao , Rick Carano , Andrea Cochran , Mike Costa , Venita DeAlmeida , James Ernst , Yan Gong , Rami Hannoush , Paul Polakis , Bonnee Rubinfeld , Mark Solloway , Yan Wu
发明人: Eric Bourhis , Tim Cao , Rick Carano , Andrea Cochran , Mike Costa , Venita DeAlmeida , James Ernst , Yan Gong , Rami Hannoush , Paul Polakis , Bonnee Rubinfeld , Mark Solloway , Yan Wu
IPC分类号: A61K39/395 , C07K16/28 , C12P21/08 , A61K39/00
CPC分类号: C07K16/28 , A61K39/3955 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/526 , C07K2317/55 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要: The invention provides anti-LRP6 antibodies and methods of using the same. A particular aspect of the invention provides for bispecific anti-LRP6 antibodies that inhibit signaling by multiple Wnt isoforms.
摘要翻译: 本发明提供抗LRP6抗体及其使用方法。 本发明的一个特定方面提供了抑制多种Wnt同种型的信号通路的双特异性抗LRP6抗体。
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公开(公告)号:US20060021317A1
公开(公告)日:2006-02-02
申请号:US11195401
申请日:2005-08-01
申请人: Mike Costa , Peter DeGroot
发明人: Mike Costa , Peter DeGroot
IPC分类号: A01D45/00
CPC分类号: A01D45/263
摘要: An apparatus that moves through fields of leafy vegetables and trims harvested heads of leafy vegetables. The apparatus includes a body and a plurality of supports coupled to the body for movement relative thereto. The supports are configured for supporting pieces of leafy vegetables. The apparatus further includes a plurality of cutters coupled to the body that are arranged serially and a transport system for moving the supports past the cutters. A collector is included for collecting leaves cut from the vegetables.
摘要翻译: 一种通过绿叶蔬菜的田地移动的装置,修剪了叶菜类的收割头。 该装置包括主体和联接到主体的多个支撑件,用于相对于其移动。 支撑件被配置为支撑叶菜类蔬菜。 该装置还包括连接到主体的多个切割器,其连续布置,以及用于使支撑件移动通过切割器的传送系统。 收集收集器用于收集从蔬菜切下的叶子。
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