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    Thermal control apparatus and method
    2.
    发明授权
    Thermal control apparatus and method 失效
    热控装置及方法

    公开(公告)号：US5628929A

    公开(公告)日：1997-05-13

    申请号：US322666

    申请日：1994-10-13

    申请人： Kurt Klosterman

    发明人： Kurt Klosterman

    IPC分类号： G05D23/24 ,  H05B1/02

    CPC分类号： G05D23/24 ,  G05D23/1917

    摘要： Embodiments described herein provide methods and apparatuses for thermally controlling an instrument. According to one embodiment, an apparatus includes a heater and a source of electrical energy electrically connected with the heater for energizing the heater to produce thermal energy. A driver is electrically connected with the heater and the source of electrical energy for controlling application of electrical energy to the heater. A sensor is electrically connected with the heater for detecting thermal energy produced by the heater responsive to the electrical energy from the source of electrical energy. A controller is electrically connected with the driver and the sensor for controlling production of thermal energy by the heater responsive to electrical energy from the source of electrical energy. Another embodiment provides a method in which a heater is electrically connected with a relatively reduced thermal energy reference resistor. An amplifier operatively associated with the heater slews to a relatively reduced thermal energy value which is recorded in memory. An algorithm controlling the heater is updated. The heater is electrically connected with a detector for sensing thermal energy produced by the heater. The amplifier slews to a value associated with the detector.

    摘要翻译： 本文所述的实施例提供了用于热控制器械的方法和装置。 根据一个实施例，一种装置包括加热器和与加热器电连接以产生热能的加热器电连接的电能源。 驱动器与加热器和电能源电连接，用于控制向加热器施加电能。 传感器与加热器电连接，用于响应于来自电能源的电能来检测由加热器产生的热能。 控制器与驱动器和传感器电连接，用于响应于来自电能源的电能来控制加热器的热能产生。 另一个实施例提供了一种方法，其中加热器与相对减少的热能参考电阻器电连接。 与加热器可操作地相关联的放大器转换成相对减小的热能值，其被记录在存储器中。 更新控制加热器的算法。 加热器与用于感测由加热器产生的热能的检测器电连接。 放大器转换到与检测器相关的值。

    Process for labeling acridinium to microparticles and application in an instrument
    3.
    发明授权
    Process for labeling acridinium to microparticles and application in an instrument 失效
    将吖啶标记为微粒并用于仪器中的方法

    公开(公告)号：US5468649A

    公开(公告)日：1995-11-21

    申请号：US196536

    申请日：1994-02-15

    申请人： Dinesh O. Shah ,  Tarun Chandra ,  Kurt Klosterman

    发明人： Dinesh O. Shah ,  Tarun Chandra ,  Kurt Klosterman

    IPC分类号： G01N21/75 ,  G01N33/58 ,  G01N33/543 ,  G01N33/546

    CPC分类号： G01N33/585

    摘要： Embodiments of the invention provide methods of preparing an activated acridinium microparticle. Generally, the methods involve direct covalent coupling or an affinity format. The direct covalent coupling method involves coating a microparticle with a proteinaceous compound. Then, a 10-methyl-N-tosyl-N-(2-carboxyethyl)-9-acridinium carboximide trifluoromethane sulfonate is coupled to the proteinaceous compound. In the affinity format, a microparticle is coated with a biotinylated proteinaceous compound. The microparticle is reacted with an anti-biotin labelled 10-methyl-N-tosyl-N-(2-carboxyethyl)-9-acridinium carboximide trifluoromethane sulfonate. Methods are also provided for using such a microparticle. Those methods of use can estimate transfer efficiency, calibrate optics, and measure membrane pore size of a chemiluminescence based instrument. Test elements for analytical instruments are also provided.

    摘要翻译： 本发明的实施方案提供了制备活化的吖啶微粒的方法。 通常，该方法涉及直接共价偶联或亲和格式。 直接共价偶联法包括用蛋白质化合物包被微粒。 然后，将10-甲基-N-甲苯磺酰基-N-（2-羧乙基）-9-吖啶鎓三氟甲磺酸酯与蛋白质化合物偶联。 在亲和性形式中，微粒被生物素化的蛋白质化合物包被。 将微粒与抗生物素标记的10-甲基-N-甲苯磺酰基-N-（2-羧乙基）-9-吖啶鎓三氟甲磺酸盐反应。 还提供了使用这种微粒的方法。 这些使用方法可以估计传递效率，校准光学和测量基于化学发光的仪器的膜孔径。 还提供了分析仪器的测试元件。