Process for labeling acridinium to microparticles and application in an
instrument
    1.
    发明授权
    Process for labeling acridinium to microparticles and application in an instrument 失效
    将吖啶标记为微粒并用于仪器中的方法

    公开(公告)号:US5468649A

    公开(公告)日:1995-11-21

    申请号:US196536

    申请日:1994-02-15

    CPC分类号: G01N33/585

    摘要: Embodiments of the invention provide methods of preparing an activated acridinium microparticle. Generally, the methods involve direct covalent coupling or an affinity format. The direct covalent coupling method involves coating a microparticle with a proteinaceous compound. Then, a 10-methyl-N-tosyl-N-(2-carboxyethyl)-9-acridinium carboximide trifluoromethane sulfonate is coupled to the proteinaceous compound. In the affinity format, a microparticle is coated with a biotinylated proteinaceous compound. The microparticle is reacted with an anti-biotin labelled 10-methyl-N-tosyl-N-(2-carboxyethyl)-9-acridinium carboximide trifluoromethane sulfonate. Methods are also provided for using such a microparticle. Those methods of use can estimate transfer efficiency, calibrate optics, and measure membrane pore size of a chemiluminescence based instrument. Test elements for analytical instruments are also provided.

    摘要翻译: 本发明的实施方案提供了制备活化的吖啶微粒的方法。 通常,该方法涉及直接共价偶联或亲和格式。 直接共价偶联法包括用蛋白质化合物包被微粒。 然后,将10-甲基-N-甲苯磺酰基-N-(2-羧乙基)-9-吖啶鎓三氟甲磺酸酯与蛋白质化合物偶联。 在亲和性形式中,微粒被生物素化的蛋白质化合物包被。 将微粒与抗生物素标记的10-甲基-N-甲苯磺酰基-N-(2-羧乙基)-9-吖啶鎓三氟甲磺酸盐反应。 还提供了使用这种微粒的方法。 这些使用方法可以估计传递效率,校准光学和测量基于化学发光的仪器的膜孔径。 还提供了分析仪器的测试元件。

    Stable blend of coal and diesel oil
    5.
    发明授权
    Stable blend of coal and diesel oil 失效
    稳定的煤和柴油混合

    公开(公告)号:US4469486A

    公开(公告)日:1984-09-04

    申请号:US359277

    申请日:1982-03-18

    IPC分类号: C10L1/32 F02B3/06

    CPC分类号: C10L1/322 F02B3/06

    摘要: A stable dispersion of powdered coal in petroleum oil comprising:5-50% by weight of pulverized coal;45-90% by weight of diesel oil or Fuel Oil No. 2; and5-20% by weight of ethanol.This dispersion is particularly useful as a liquid fuel.

    摘要翻译: 粉煤在石油中的稳定分散体,其中包括:5-50%重量的粉煤; 45-90重量%柴油或燃油2号; 和5-20重量%的乙醇。 该分散体作为液体燃料是特别有用的。

    Micelles and Nanoemulsions for Preventive and Reactive Treatment of Atherosclerosis
    6.
    发明申请
    Micelles and Nanoemulsions for Preventive and Reactive Treatment of Atherosclerosis 审中-公开
    胶束和纳米乳剂用于动脉粥样硬化的预防和反应性治疗

    公开(公告)号:US20080311207A1

    公开(公告)日:2008-12-18

    申请号:US11662157

    申请日:2005-09-08

    IPC分类号: A61K9/14

    CPC分类号: A61K9/1075

    摘要: The subject invention is directed to microemulsion-based (ME) nanoparticles and methods of using same. The ME nanoparticles of the subject invention encompass self-assemblies of oil in water emulsions in the presence of at least two emulsifiers. One of the emulsifiers is a salt of a fatty acid, and the combined concentration of the at least two emulsifiers is sufficiently large to produce micelles, wherein the oil droplets are the hydrophobic core of the micelles. The subject invention also contemplates methods of modifying lipids, high density lipoprotein (HDL), and low density lipoprotein (LDL) in blood by contacting the blood with the ME nanoparticles of the subject invention. Another aspect concerns methods for treating atherosclerosis by administering the ME nanoparticles of the subject invention to a patient in need thereof.

    摘要翻译: 本发明涉及基于微乳液的(ME)纳米颗粒及其使用方法。 本发明的ME纳米颗粒包括在至少两种乳化剂存在下的水包油乳液的自组装。 乳化剂之一是脂肪酸的盐,并且至少两种乳化剂的组合浓度足够大以产生胶束,其中油滴是胶束的疏水核心。 本发明还考虑通过使血液与本发明的ME纳米颗粒接触来改变血液中脂质,高密度脂蛋白(HDL)和低密度脂蛋白(LDL)的方法。 另一方面涉及通过将本发明的ME纳米颗粒给予有需要的患者来治疗动脉粥样硬化的方法。

    Low viscosity stable mixtures of coal and fuel oil containing alcohol
    9.
    发明授权
    Low viscosity stable mixtures of coal and fuel oil containing alcohol 失效
    低粘度稳定的煤和含有燃料油的混合物

    公开(公告)号:US4453947A

    公开(公告)日:1984-06-12

    申请号:US359372

    申请日:1982-03-18

    IPC分类号: C10L1/02 C10L1/32

    CPC分类号: C10L1/322 C10L1/02

    摘要: A stable homogeneous liquid fuel composition comprising a petroleum residual oil having a viscosity at room temperature of 1-2.5 poises, an alcohol of 1-2 carbon atoms, and a hydrocarbon coupling agent. This composition has utility as a fuel per se and as a liquid carrier in which powdered coal can be dispered to produce another liquid fuel.

    摘要翻译: 一种稳定均匀的液体燃料组合物,其包含在室温下为1-2.5泊的粘度,1-2个碳原子的醇和烃偶合剂的石油残油。 该组合物作为燃料本身具有效用,并且作为液体载体可以分散粉煤以产生另一液体燃料。