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1.发明授权公开(公告)号：US07114368B2
公开(公告)日：2006-10-03
申请号：US10409282
申请日：2003-04-08
申请人： Kurt M. Klosterman , Ganesh Rajagopal , Larry R. Jibson , James L. Dempski , Paul A. Matuszewski , Jeffrey W. Stewart , Jeffrey R. Swanson , David M. Tipotsch , Randall E. Youngs , Noman A. Abunimeh
发明人： Kurt M. Klosterman , Ganesh Rajagopal , Larry R. Jibson , James L. Dempski , Paul A. Matuszewski , Jeffrey W. Stewart , Jeffrey R. Swanson , David M. Tipotsch , Randall E. Youngs , Noman A. Abunimeh
CPC分类号： B01L3/0293 , B01L2200/148 , G01F25/0092 , G01G17/04 , G01N35/1016 , G01N2035/00217
摘要： An apparatus for improving the procedure for quantifying the volume of liquid dispensed by a liquid-dispensing mechanism of an analytical instrument. The apparatus of this invention comprises (a) at least one weigh cup; (b) at least one standard mass; (c) at least one transducer assembly to convert a value of weight to an electrical response; and (d) at least one electronic circuit for converting the electrical response to a measurement of volume. This invention provides a method for calibrating readings of the volume of liquid dispensed by a liquid-dispensing mechanism of an analytical instruments so that absolute measurements of the volume of liquid dispensed can be obtained.
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2.发明授权Apparatus and method for verifying the volume of liquid dispensed by a liquid-dispensing mechanism 失效用于验证由液体分配机构分配的液体的体积的装置和方法公开(公告)号：US08434345B2
公开(公告)日：2013-05-07
申请号：US11503334
申请日：2006-08-11
申请人： Kurt M. Klosterman , Ganesh Rajagopal , Larry R. Jibson , James L. Dempski , Paul A. Matuszewski , Jeffrey W. Stewart , Jeffrey R. Swanson , David M. Tipotsch , Randall E. Youngs , Noman A. Abunimeh
发明人： Kurt M. Klosterman , Ganesh Rajagopal , Larry R. Jibson , James L. Dempski , Paul A. Matuszewski , Jeffrey W. Stewart , Jeffrey R. Swanson , David M. Tipotsch , Randall E. Youngs , Noman A. Abunimeh
CPC分类号： B01L3/0293 , B01L2200/148 , G01F25/0092 , G01G17/04 , G01N35/1016 , G01N2035/00217
摘要： An apparatus for improving the procedure for quantifying the volume of liquid dispensed by a liquid-dispensing mechanism of an analytical instrument. The apparatus of this invention comprises (a) at least one weigh cup; (b) at least one standard mass; (c) at least one transducer assembly to convert a value of weight to an electrical response; and (d) at least one electronic circuit for converting the electrical response to a measurement of volume. This invention provides a method for calibrating readings of the volume of liquid dispensed by a liquid-dispensing mechanism of an analytical instruments so that absolute measurements of the volume of liquid dispensed can be obtained.
摘要翻译： 一种用于改进用于量化由分析仪器的液体分配机构分配的液体的体积的程序的装置。 本发明的装置包括（a）至少一个称重杯; （b）至少一个标准质量; （c）至少一个换能器组件，用于将重量值转换成电响应; 和（d）至少一个用于将电响应转换成体积测量的电子电路。 本发明提供了一种用于校准由分析仪器的液体分配机构分配的液体的体积的读数的方法，以便可以获得分配的液体的体积的绝对测量。
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公开(公告)号：US20080142037A1
公开(公告)日：2008-06-19
申请号：US11641338
申请日：2006-12-19
IPC分类号： B08B3/12
CPC分类号： B08B3/12 , B01L3/021 , B01L13/02 , B01L2200/141 , B01L2400/0439 , B08B9/00
摘要： A method for cleaning deposits of particulate material from the tip of a nozzle of a dispensing apparatus, such as, for example, the tip of the nozzle of a liquid reagent dispensing apparatus. The method involves the use of a multiple excitation signal waveform to cavitate and agitate the cleaning medium in which the tip of the nozzle is suspended. Multiple excitation refers to a method of excitation that uses waves of alternating polarity; multiple excitation may involve excitation at a plurality of frequencies in sequence, at a plurality of amplitudes in sequence, at a plurality of waveforms in sequence, combinations of the aforementioned frequencies, amplitudes, and waveforms. The invention also provides an apparatus incorporating electrical and mechanical components, along with appropriate software, sufficient to perform the method described herein.
摘要翻译： 从分配装置的喷嘴的尖端（例如液体试剂分配装置的喷嘴的尖端）清除颗粒材料的沉积物的方法。 该方法涉及使用多重激发信号波形来空化和搅动其中悬挂尖端的清洁介质。 多重激励是指使用交替极性波的激发方法; 多次激励可以包括在多个频率下依次以多个幅度依次以多个波形依次激励，上述频率，幅度和波形的组合。 本发明还提供了一种装有电气和机械组件以及适当的软件的装置，其足以执行本文所述的方法。
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公开(公告)号：US08368009B2
公开(公告)日：2013-02-05
申请号：US13465408
申请日：2012-05-07
IPC分类号： G12B13/00
CPC分类号： H01J65/08 , G01J1/20 , G01N23/223 , G01N2223/076
摘要： An example optic module verification device for use in periodic normalization of a testing machine used to test samples in wells is disclosed. The example testing machine includes a plurality of photon counters that each count photons emitted from different wells. The example verification device includes a plurality of verification wells located so as to each be associated with one of the photon counters when used in the testing machine. The example device also includes a photon emitter in each verification well, each photon emitter including a C14 source, a scintillator adjacent the C14 source, and a filter over the scintillator. The example photon emitters each have a determined initial base value for emitted photons, and each photon emitter is positioned in its verification well to emit photons through the filter to the associated photon counter when used in the testing machine.
摘要翻译： 公开了一种用于在井中测试样品的测试机的周期性归一化中使用的示例性光学模块验证装置。 示例性测试机器包括多个光子计数器，每个光子计数器计数从不同孔发射的光子。 示例性验证装置包括多个验证孔，其位于当在测试机器中使用时各自与光子计数器中的一个相关联。 示例性装置还包括每个验证井中的光子发射器，每个光子发射器包括C14源，与C14源相邻的闪烁体和闪烁体上的滤光器。 示例性光子发射器各自具有用于发射光子的确定的初始基值，并且当在测试机中使用时，每个光子发射器位于其验证井中，以将光子通过滤光器发射到相关联的光子计数器。
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公开(公告)号：US08686347B2
公开(公告)日：2014-04-01
申请号：US13750330
申请日：2013-01-25
IPC分类号： G12B13/00
CPC分类号： H01J65/08 , G01J1/20 , G01N23/223 , G01N2223/076
摘要： Example apparatus and methods for use in normalization of testing machines used to test samples in vessels are disclosed. An example apparatus includes verification source and a photon emitter positioned in the verification source. The example photon emitter includes a C14 source, a scintillator adjacent to the C14 source, and a filter adjacent to the scintillator. The example photon emitter is to emit photons through the filter for detection by a photon counter.
摘要翻译： 公开了用于在容器中测试样品的试验机的标准化中使用的示例性装置和方法。 示例性设备包括位于验证源中的验证源和光子发射器。 示例性光子发射器包括C14源，与C14源相邻的闪烁体和与闪烁体相邻的滤光器。 示例性光子发射器将通过滤光器发射光子，以由光子计数器检测。
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公开(公告)号：US20120217385A1
公开(公告)日：2012-08-30
申请号：US13465408
申请日：2012-05-07
CPC分类号： H01J65/08 , G01J1/20 , G01N23/223 , G01N2223/076
摘要： An example optic module verification device for use in periodic normalization of a testing machine used to test samples in wells is disclosed. The example testing machine includes a plurality of photon counters that each count photons emitted from different wells. The example verification device includes a plurality of verification wells located so as to each be associated with one of the photon counters when used in the testing machine. The example device also includes a photon emitter in each verification well, each photon emitter including a C14 source, a scintillator adjacent the C14 source, and a filter over the scintillator. The example photon emitters each have a determined initial base value for emitted photons, and each photon emitter is positioned in its verification well to emit photons through the filter to the associated photon counter when used in the testing machine.
摘要翻译： 公开了一种用于在井中测试样品的测试机的周期性归一化中使用的示例性光学模块验证装置。 示例性测试机器包括多个光子计数器，每个光子计数器计数从不同孔发射的光子。 示例性验证装置包括多个验证孔，其位于当在测试机器中使用时各自与光子计数器中的一个相关联。 示例性装置还包括每个验证井中的光子发射器，每个光子发射器包括C14源，与C14源相邻的闪烁体和闪烁体上的滤光器。 示例性光子发射器各自具有用于发射光子的确定的初始基值，并且当在测试机中使用时，每个光子发射器位于其验证井中，以将光子通过滤光器发射到相关联的光子计数器。
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公开(公告)号：US07858924B2
公开(公告)日：2010-12-28
申请号：US11637314
申请日：2006-12-12
CPC分类号： H01J65/08 , G01J1/20 , G01N23/223 , G01N2223/076
摘要： An optic module verification device for normalizing between X photon counters, including a verification tray with X verification wells and a modular photon emitter in each verification well. Each photon emitter includes a spring, a Beta source disk, a scintillator disk adjacent the Beta source disk, and a neutral density filter over the scintillator disk, all of which are encapsulated in a cylindrical chamber with the filter adjacent an opening on one end of the chamber and the spring biasing the Beta source disk and the scintillator disk toward the opening. The device is periodically used for normalization, and may be updated when emitted photons fall below a desired level by replacing the scintillator disk and then determining a new normalized reference values for each photon emitter.
摘要翻译： 用于在X光子计数器之间进行归一化的光学模块验证装置，包括具有X个验证孔的验证盘和每个验证井中的模块化光子发射器。 每个光子发射器包括弹簧，β源盘，与β源盘相邻的闪烁体盘，以及在闪烁体盘上的中性密度滤光片，所有这些都被封装在圆柱形腔室中，过滤器邻近一端的开口 腔室和弹簧将Beta源盘和闪烁体盘偏置到开口。 周期性地使用该装置进行归一化，并且当发射的光子通过替换闪烁体盘然后确定每个光子发射器的新的归一化参考值而降低到期望的水平以下时，可以更新该装置。
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公开(公告)号：US20130140444A1
公开(公告)日：2013-06-06
申请号：US13750330
申请日：2013-01-25
CPC分类号： H01J65/08 , G01J1/20 , G01N23/223 , G01N2223/076
摘要： Example apparatus and methods for use in normalization of testing machines used to test samples in vessels are disclosed. An example apparatus includes verification source and a photon emitter positioned in the verification source. The example photon emitter includes a C14 source, a scintillator adjacent to the C14 source, and a filter adjacent to the scintillator. The example photon emitter is to emit photons through the filter for detection by a photon counter.
摘要翻译： 公开了用于在容器中测试样品的试验机的标准化中使用的示例性装置和方法。 示例性设备包括位于验证源中的验证源和光子发射器。 示例性光子发射器包括C14源，与C14源相邻的闪烁体和与闪烁体相邻的滤光器。 示例性光子发射器将通过滤光器发射光子，以由光子计数器检测。
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公开(公告)号：US08173972B2
公开(公告)日：2012-05-08
申请号：US12951783
申请日：2010-11-22
IPC分类号： G21G4/00
CPC分类号： H01J65/08 , G01J1/20 , G01N23/223 , G01N2223/076
摘要： An optic module verification device for normalizing between X photon counters, including a verification tray with X verification wells and a modular photon emitter in each verification well. Each photon emitter includes a spring, a Beta source disk, a scintillator disk adjacent the Beta source disk, and a neutral density filter over the scintillator disk, all of which are encapsulated in a cylindrical chamber with the filter adjacent an opening on one end of the chamber and the spring biasing the Beta source disk and the scintillator disk toward the opening. The device is periodically used for normalization, and may be updated when emitted photons fall below a desired level by replacing the scintillator disk and then determining a new normalized reference values for each photon emitter.
摘要翻译： 用于在X光子计数器之间进行归一化的光学模块验证装置，包括具有X个验证孔的验证盘和每个验证井中的模块化光子发射器。 每个光子发射器包括弹簧，β源盘，与β源盘相邻的闪烁体盘，以及在闪烁体盘上的中性密度滤光片，所有这些都被封装在圆柱形腔室中，过滤器邻近一端的开口 腔室和弹簧将Beta源盘和闪烁体盘偏置到开口。 周期性地使用该装置进行标准化，并且当发射的光子通过替换闪烁体盘然后确定每个光子发射器的新的归一化参考值而降低到期望水平以下时，可以更新该装置。
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公开(公告)号：US20110062352A1
公开(公告)日：2011-03-17
申请号：US12951783
申请日：2010-11-22
IPC分类号： G21G4/00
CPC分类号： H01J65/08 , G01J1/20 , G01N23/223 , G01N2223/076
摘要： An optic module verification device for normalizing between X photon counters, including a verification tray with X verification wells and a modular photon emitter in each verification well. Each photon emitter includes a spring, a Beta source disk, a scintillator disk adjacent the Beta source disk, and a neutral density filter over the scintillator disk, all of which are encapsulated in a cylindrical chamber with the filter adjacent an opening on one end of the chamber and the spring biasing the Beta source disk and the scintillator disk toward the opening. The device is periodically used for normalization, and may be updated when emitted photons fall below a desired level by replacing the scintillator disk and then determining a new normalized reference values for each photon emitter.
摘要翻译： 用于在X光子计数器之间进行归一化的光学模块验证装置，包括具有X个验证孔的验证盘和每个验证井中的模块化光子发射器。 每个光子发射器包括弹簧，β源盘，与β源盘相邻的闪烁体盘，以及在闪烁体盘上的中性密度滤光片，所有这些都被封装在圆柱形腔室中，过滤器邻近一端的开口 腔室和弹簧将Beta源盘和闪烁体盘偏置到开口。 周期性地使用该装置进行归一化，并且当发射的光子通过替换闪烁体盘然后确定每个光子发射器的新的归一化参考值而降低到期望的水平以下时，可以更新该装置。
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