摘要:
Adaptive line synthesis is provided. Line synthesis of collinear receive beams responsive to spatially distinct transmit beams is a function of many parameters, such as spatial or temporal frequency response of one or more of the receive beams, synthesis function, number of receive beams synthesized, or acquisition sequence. One or more of these parameters is set or adapts as a function of processor estimated or user provided information. By adapting the line synthesis, the performance and image quality is optimized as appropriate for the received data or desired imaging, such as detail resolution, contrast resolution, temporal resolution, shift-invariance and penetration.
摘要:
A set of N×M signals are acquired from an object, where N is the number of array elements and M corresponds to variations in data acquisition and/or processing parameters. The parameters include transmit aperture functions, transmit waveforms, receive aperture functions, and receive filtering functions in space and/or time. A coherence factor is computed as a ratio of the energy of the coherent sum to the energy of the at-least-partially incoherent sum of channel or image signals acquired with at least one different parameter. Partial beamformed data may be used for channel coherence calculation. For image domain coherence, a component image is formed for each different transmit beam or receive aperture function, and a coherence factor image is computed using the set of component images. The coherence factor image is displayed or used to modify or blend other images formed of the same region.
摘要:
Transmit multibeams insonify an object with multiple noncollinear transmit beams fired substantially simultaneously. The noncollinear beams are along different scan lines of same scan geometry, or they belong to scan lines of different scan geometries. One or more receive beams are formed in parallel in response to each of the noncollinear beams. The scan geometry and/or center frequency is varied between the noncollinear transmit beams of a transmit event. By scanning the transmit multibeam, and varying the scan geometry and/or frequency between the noncollinear transmit beams of a transmit event, multiple component images are generated for compounding. The component images are scan-converted (if scan geometries are different), weighted and combined after envelope detection.
摘要:
Provided herein are methods, compositions and kits for the treatment of locally advanced or metastatic breast cancer or breast cancer brain metastases. The method comprises administration of 4-iodo-3-nitrobenzamide, a metabolite or salt thereof in combination with irinotecan. The method of treating locally advanced or metastatic breast cancer comprises at least one 21 day treatment cycle.
摘要:
A medical diagnostic ultrasonic imaging method and system subdivide the transmit aperture into two or more subapertures, each subaperture having at least four adjacent transducer elements. The subapertures are phased differently with respect to one another to selectively reduce either fundamental components or harmonic components of echoes from tissue. These techniques can be used to improve contrast agent harmonic imaging as well as tissue harmonic imaging, depending upon the phase shift selected.
摘要:
In one aspect, the present invention provides a method of treating breast cancer that is negative for at least one of ER, PR, or HER2, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating breast cancer comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.
摘要:
In one aspect, the present invention provides a method of treating uterine cancer, endometrial cancer, or ovarian cancer, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating uterine cancer, endometrial cancer, or ovarian cancer, comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.
摘要:
An embodiment provides a shift inhibitor apparatus. At least a portion of the range actuating assembly is moveable between a range first ratio and a range second ratio. The portion of the range actuating assembly is moveable, at least in part, in response to a fluid pressure. The range chamber is selectively in fluid communication with a vent. The shift inhibitor includes a main section neutral interlock having an interlock chamber. At least a portion of the main section neutral interlock is moveable between a first condition and a second condition. The interlock chamber is selectively in fluid communication with the vent. The range chamber can be exhausted such that the range section is selectively switched from the first ratio to the second ratio. The interlock chamber can be exhausted such that the main section neutral interlock is selectively switched from the first condition to the second condition.
摘要:
An embodiment provides a shift inhibitor apparatus. At least a portion of the range actuating assembly is moveable between a range first ratio and a range second ratio. The portion of the range actuating assembly is moveable, at least in part, in response to a fluid pressure. The range chamber is selectively in fluid communication with a vent. The shift inhibitor includes a main section neutral interlock having an interlock chamber. At least a portion of the main section neutral interlock is moveable between a first condition and a second condition. The interlock chamber is selectively in fluid communication with the vent. The range chamber can be exhausted such that the range section is selectively switched from the first ratio to the second ratio. The interlock chamber can be exhausted such that the main section neutral interlock is selectively switched from the first condition to the second condition.
摘要:
In one aspect, the present invention provides a method of treating lung cancer, comprising administering to a subject at least one PARP inhibitor in combination with at least one growth factor inhibitor. In another aspect, the present invention provides a method of treating non-small cell lung cancer comprising administering to a subject at least one PARP inhibitor in combination with at least one growth factor inhibitor.