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公开(公告)号：US5681830A
公开(公告)日：1997-10-28
申请号：US285313
申请日：1994-08-03
申请人： Kwen-Jen Chang , Dulce G. Bubacz , Ann O. Davis , Robert W. McNutt, Jr. , Mark A. Collins , Michael J. Bishop
发明人： Kwen-Jen Chang , Dulce G. Bubacz , Ann O. Davis , Robert W. McNutt, Jr. , Mark A. Collins , Michael J. Bishop
IPC分类号： C07D211/70 , C07D213/38 , C07D213/75 , C07D213/82 , C07D277/28 , C07D295/02 , C07D295/03 , C07D295/096 , C07D295/135 , C07D295/155 , C07D295/192 , C07D333/20 , C07D333/28 , C07D333/38 , C07K5/06 , C07K5/065 , A61K31/495 , A61K31/675 , C07D241/04 , C07D401/12
CPC分类号： C07D211/70 , C07D213/38 , C07D213/75 , C07D213/82 , C07D277/28 , C07D295/03 , C07D295/096 , C07D295/135 , C07D295/155 , C07D295/192 , C07D333/20 , C07D333/28 , C07D333/38 , C07K5/06026 , C07K5/06078 , C07C2101/02
摘要： Diarylmethyl piperazine compounds having utility as exogenous receptor combinant species for binding with receptors such as delta, mu, sigma, and/or kappa receptors are disclosed. Compounds of the invention may be employed as conjugates in agonist/antagonist pairs for transductional monitoring and assays of neurotransmitter function, and also variously exhibit therapeutic utility, including mediating analgesia, and possessing utility for the treatment of diarrhea, urinary incontinence, mental illness, drug and alcohol addiction/overdose, lung edema, depression, asthma, emphysema, cough, and apnea, respiratory depression, cognitive disorders, emesis and gastrointestinal disorders.
摘要翻译： 公开了作为用于与诸如δ，mu，σ和/或kappa受体的受体结合的外源受体组合物质的二芳基甲基哌嗪化合物。 本发明的化合物可用作激动剂/拮抗剂对中的缀合物用于传导监测和神经递质功能的测定，并且还各种表现出治疗效用，包括介导镇痛，并具有用于治疗腹泻，尿失禁，精神疾病，药物 酒精成瘾/过量，肺水肿，抑郁症，哮喘，肺气肿，咳嗽和呼吸暂停，呼吸抑制，认知障碍，呕吐和胃肠道疾病。
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公开(公告)号：US5574159A
公开(公告)日：1996-11-12
申请号：US430677
申请日：1995-04-28
IPC分类号： C07D211/70 , C07D213/38 , C07D213/75 , C07D213/82 , C07D277/28 , C07D295/02 , C07D295/03 , C07D295/096 , C07D295/135 , C07D295/155 , C07D295/192 , C07D333/20 , C07D333/28 , C07D333/38 , C07K5/06 , C07K5/065 , C07D403/10
CPC分类号： C07D213/75 , C07D211/70 , C07D213/38 , C07D213/82 , C07D277/28 , C07D295/03 , C07D295/096 , C07D295/135 , C07D295/155 , C07D295/192 , C07D333/20 , C07D333/28 , C07D333/38 , C07K5/06026 , C07K5/06078 , C07C2101/02
摘要： Diarylmethyl piperazine compounds having utility as exogenous receptor combinant species for binding with receptors such as delta, mu, sigma, and/or kappa receptors are disclosed. Compounds of the invention may be employed as conjugates in agonist/antagonist pairs for transductional monitoring and assays of neurotransmitter function, and also variously exhibit therapeutic utility, including mediating analgesia, and possessing utility for the treatment of diarrhea, urinary incontinence, mental illness, drug and alcohol addiction/overdose, lung edema, depression, asthma, emphysema, cough, and apnea, respiratory depression, cognitive disorders, emesis and gastrointestinal disorders.
摘要翻译： 公开了作为用于与诸如δ，mu，σ和/或kappa受体的受体结合的外源受体组合物质的二芳基甲基哌嗪化合物。 本发明的化合物可用作激动剂/拮抗剂对中的缀合物用于传导监测和神经递质功能的测定，并且还各种表现出治疗效用，包括介导镇痛，并具有用于治疗腹泻，尿失禁，精神疾病，药物 酒精成瘾/过量，肺水肿，抑郁症，哮喘，肺气肿，咳嗽和呼吸暂停，呼吸抑制，认知障碍，呕吐和胃肠道疾病。
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公开(公告)号：US5552404A
公开(公告)日：1996-09-03
申请号：US431377
申请日：1995-04-28
IPC分类号： C07D295/14 , A61K31/495 , A61P1/00 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/00 , A61P25/04 , A61P25/24 , A61P25/26 , A61P25/30 , A61P43/00 , C07D213/75 , C07D295/155 , A61K31/445
CPC分类号： C07D213/75 , C07D295/155 , C07C2101/02
摘要： Diarylmethyl piperazine compounds having utility as exogenous receptor combinant species for binding with receptors such as delta, mu, sigma, and/or kappa receptors are disclosed. Compounds of the invention may be employed as conjugates in agonist/antagonist pairs for transductional monitoring and assays of neurotransmitter function, and also variously exhibit therapeutic utility, including mediating analgesia, and possessing utility for the treatment of diarrhea, urinary incontinence, mental illness, drug and alcohol addiction/overdose, lung edema, depression, asthma, emphysema, cough, and apnea, respiratory depression, cognitive disorders, emesis and gastrointestinal disorders.
摘要翻译： 公开了作为用于与诸如δ，mu，σ和/或kappa受体的受体结合的外源受体组合物质的二芳基甲基哌嗪化合物。 本发明的化合物可用作激动剂/拮抗剂对中的缀合物用于传导监测和神经递质功能的测定，并且还各种表现出治疗效用，包括介导镇痛，并具有用于治疗腹泻，尿失禁，精神疾病，药物 酒精成瘾/过量，肺水肿，抑郁症，哮喘，肺气肿，咳嗽和呼吸暂停，呼吸抑制，认知障碍，呕吐和胃肠道疾病。
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