公开(公告)号：US20250012782A1

公开(公告)日：2025-01-09

申请号：US18896655

申请日：2024-09-25

Applicant: L'OREAL

Inventor： Rodrigo De Vecchi ,  Lionel Breton ,  Charbel Bouez ,  Vanja Dakic

IPC: G01N33/50 ,  C12N5/00 ,  C12N5/071 ,  C12N5/0793

Abstract: The present invention relates to a kit comprising a co-culture microdevice containing peripheral sensory neurons (PSN) and human epidermal keratinocytes (HEK) in a cell culture adapted for both cell types. It is also described a method for screening an active compound using the kit according to the present invention, as well as the use thereof for in vitro drug tests and for producing a cosmetic product for various dermatological applications, such as atopic dermatitis, sensitive skin, photoaging, wound healing and epidermal thickness in aged skin.