公开(公告)号：US20250134792A1

公开(公告)日：2025-05-01

申请号：US18498706

申请日：2023-10-31

Applicant: L'Oreal

Inventor： Rebecca BARRESI ,  Charbel Bouez ,  Carine Ballihaut ,  Elena Catalan Martin ,  Franck Juchaux ,  Julien Laboureau ,  Jinyuan Yan

IPC: A61K8/60 ,  A61K8/67 ,  A61Q19/00

Abstract: The disclosure relates to compositions and methods for improving the appearance of skin. The methods comprise treating skin tissue with at least one C-glycoside or derivative thereof, at least one vitamin B3 or derivative thereof and at least one skin modification stimulus, and the compositions comprise at least one C-glycoside or derivative thereof and/or at least one vitamin B3 or derivative thereof.

公开(公告)号：US20250012782A1

公开(公告)日：2025-01-09

申请号：US18896655

申请日：2024-09-25

Applicant: L'OREAL

Inventor： Rodrigo De Vecchi ,  Lionel Breton ,  Charbel Bouez ,  Vanja Dakic

IPC: G01N33/50 ,  C12N5/00 ,  C12N5/071 ,  C12N5/0793

Abstract: The present invention relates to a kit comprising a co-culture microdevice containing peripheral sensory neurons (PSN) and human epidermal keratinocytes (HEK) in a cell culture adapted for both cell types. It is also described a method for screening an active compound using the kit according to the present invention, as well as the use thereof for in vitro drug tests and for producing a cosmetic product for various dermatological applications, such as atopic dermatitis, sensitive skin, photoaging, wound healing and epidermal thickness in aged skin.

公开(公告)号：US12121606B2

公开(公告)日：2024-10-22

申请号：US17218945

申请日：2021-03-31

Applicant: L'OREAL

Inventor： I-Chien Liao ,  Patricia Brieva ,  Janet Wangari-Talbot ,  Charbel Bouez ,  Qian Zheng ,  Kun Qian

IPC: A61K8/42 ,  A61K8/06 ,  A61K8/34 ,  A61K8/368 ,  A61K8/37 ,  A61K8/49 ,  A61K8/73 ,  A61K8/891 ,  A61K8/92 ,  A61K8/9789 ,  A61Q19/00

CPC classification number: A61K8/42 ,  A61K8/06 ,  A61K8/345 ,  A61K8/368 ,  A61K8/37 ,  A61K8/4913 ,  A61K8/735 ,  A61K8/891 ,  A61K8/922 ,  A61K8/927 ,  A61K8/9789 ,  A61Q19/00 ,  A61K2800/48

Abstract: A method for improving skin comprising reducing the barrier function of skin, and applying a skin treatment composition to the skin. The skin treatment composition may include about 0.1 to about 25 wt. % of acetyl trifluoromethylphenyl valylglycine; about 0.5 to about 30 wt. % of a polyol; about 0.1 to about 30 wt. % of a silicone, fatty compound, or a mixtures thereof, wherein the skin treatment composition is an emulsion, and all weight percentages are based on the total weight of the skin treatment composition.

公开(公告)号：US12036300B2

公开(公告)日：2024-07-16

申请号：US17218773

申请日：2021-03-31

Applicant: L'OREAL

Inventor： I-Chien Liao ,  Patricia Brieva ,  Franck Juchaux ,  Charbel Bouez ,  Qian Zheng ,  Kun Qian

IPC: A61K8/42 ,  A61K8/06 ,  A61K8/31 ,  A61K8/37 ,  A61K8/892 ,  A61Q19/02 ,  A61Q19/08

CPC classification number: A61K8/42 ,  A61K8/06 ,  A61K8/31 ,  A61K8/37 ,  A61K8/892 ,  A61Q19/02 ,  A61Q19/08

Abstract: A method for managing skin tone comprising reducing the synthesis of melanin by applying a skin treatment composition to skin. The skin treatment composition may include about 0.1 to about 25 wt. % of acetyl trifluoromethylphenyl valylglycine; about 0.5 to about 30 wt. % of a polyol; about 0.1 to about 30 wt. % of a silicone, fatty compound, or a mixtures thereof, wherein the skin treatment composition is an emulsion, and all weight percentages are based on the total weight of the skin treatment composition.

公开(公告)号：US20240082279A1

公开(公告)日：2024-03-14

申请号：US17900094

申请日：2022-08-31

Applicant: L'Oreal

Inventor： I-Chien LIAO ,  Charbel Bouez ,  Chunmei Ding ,  Chunyan He ,  Qian Zheng

IPC: A61K31/7004 ,  A61B18/20

CPC classification number: A61K31/7004 ,  A61B18/203 ,  A61B2018/00577

Abstract: The disclosure relates to compositions and methods for preventing, reducing, and/or treating scars. The compositions comprise at least one C-glycoside or derivative thereof, and the methods comprise treating skin and/or scar tissue with at least one C-glycoside or derivative thereof and at least one skin modification stimulus.

公开(公告)号：US20230043556A1

公开(公告)日：2023-02-09

申请号：US17877814

申请日：2022-07-29

Applicant: L'Oreal

Inventor： Daniel Christopher Roy ,  Charbel Bouez ,  Sarah Hubert

IPC: A61K35/36 ,  A61L27/38 ,  C12N5/071

Abstract: The disclosure relates to novel compositions comprising 1) conditioned media, 2) combinations of secreted biomolecules/organic molecules, and/or 3) secreted extracellular vesicles/exosomes collected from differentiated epithelial cell culture, as well as methods of making and using such compositions.

公开(公告)号：US20170326059A1

公开(公告)日：2017-11-16

申请号：US15527995

申请日：2015-11-19

Applicant: Agency for Science, Technology and Research ,  L'Oreal

Inventor： Simon Cool ,  Victor Nurcombe ,  Charbel Bouez ,  Diah Saraswati Bramono

IPC: A61K8/73 ,  A61Q19/08 ,  A61Q19/00 ,  C08B37/00

CPC classification number: A61K8/73 ,  A61K2800/10 ,  A61Q19/007 ,  A61Q19/08 ,  C08B37/0075

Abstract: Affinity purification of fibroblast growth factor 2-binding heparan sulphate from porcine mucosa (HS8) is disclosed. Also disclosed is a process for the care of keratinous material(s), comprising the application or administration of HS8, or a composition comprising thereof, to keratinous material(s). The composition may be used to improve the condition of skin, such as smoothing the skin, restoring skin elasticity and firmness, or decreasing or preventing wrinkles, and may be formulated for topical or transdermal administration.