公开(公告)号：US11785937B2

公开(公告)日：2023-10-17

申请号：US16766900

申请日：2018-11-27

申请人： LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES

发明人： Joffrey De Larichaudy ,  Sandy Cazalon Nemorin

IPC分类号： A01N1/02 ,  A61K47/18 ,  A61K47/20

CPC分类号： A01N1/0221 ,  A61K47/183 ,  A61K47/20

摘要： The present invention relates to a composition comprising, in a physiologically acceptable medium:



a) at least one saccharide,
b) at least one amino acid,
c) DMSO or at least one C3-C5 alkanediol,
d) at least one antioxidant, and
e) cells for therapeutic purposes,




said composition having a pH between 7.0 and 8.5, preferably between 7.0 and 8.3. It also relates to a method for the cryopreservation of at least one sample of cells for therapeutic purposes, comprising the following steps:
i) mixing the sample of cells for therapeutic purposes with ingredients a) to d) above and a physiologically acceptable medium, so as to obtain a composition having a pH between 7.0 and 8.5, preferably between 7.0 and 8.3, then
ii) freezing the composition obtained in step i).

公开(公告)号：US11412730B2

公开(公告)日：2022-08-16

申请号：US15737469

申请日：2016-06-30

申请人： LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES

发明人： Joffrey De Larichaudy

IPC分类号： A01N1/02 ,  A61K47/20 ,  A61K47/26 ,  A61K47/42 ,  A61K35/33 ,  A61K35/34 ,  A61K38/38 ,  A61K35/15 ,  A61K35/17 ,  A61K9/00 ,  A61K47/18 ,  A61K35/14 ,  A61K35/28

摘要： Disclosed is a composition including, in a physiologically acceptable medium: a) human albumin; b) at least one saccharide; c) DMSO and L-cysteine or coenzyme Q10; and d) cells for therapeutic purposes, with the exception of specific tumour-infiltrating lymphocytes.