专利检索 ap:("LANZHOU VETERINARY RESEARCH INSTITUTE, CHINESE ACADEMY OF AGRICULTURAL SCIENCES") AND inv:"Huimei Cui" 第 1 页

1.

发明授权
Use of compound aprepitant in preparation of drug for preventing or treating African swine fever (ASF) 有权

公开(公告)号：US11883411B2

公开(公告)日：2024-01-30

申请号：US17895390

申请日：2022-08-25

申请人： LANZHOU VETERINARY RESEARCH INSTITUTE, CHINESE ACADEMY OF AGRICULTURAL SCIENCES

发明人： Keshan Zhang , Haixue Zheng , Huimei Cui , Bo Yang , Hong Tian , Zixiang Zhu , Tao Feng , Fan Yang , Weijun Cao , Xusheng Ma , Yi Ru , Jianhong Guo , Xiangtao Liu

IPC分类号： A61K31/5377 , A61P31/20

CPC分类号： A61K31/5377 , A61P31/20

摘要： The present disclosure belongs to the technical field of African swine fever (ASF) treatment, in particular to use of a compound aprepitant in prevention or treatment of the ASF. In the present disclosure, it is found that the compound aprepitant can significantly inhibit replication of an African swine fever virus (ASFV); in addition, it is found that the aprepitant inhibits transcription and protein expression of D1133L, and reduces transcription and protein expression levels of p30 and p72, preventing virus invasion on host cells. Therefore, the compound aprepitant can be used to inhibit early and late infection of the ASFV. Accordingly, the compound aprepitant can be used to prevent or treat the ASF.