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公开(公告)号：US11883482B2
公开(公告)日：2024-01-30
申请号：US17328135
申请日：2021-05-24
发明人： Haixue Zheng , Fan Yang , Zixiang Zhu , Weijun Cao , Hong Tian , Keshan Zhang , Ting Wei , Min Zheng , Wei Zhang , Wen Dang , Xusheng Ma , Dan Li , Yi Ru , Jijun He , Jianhong Guo , Xiangtao Liu
IPC分类号： C12N7/00 , C12N15/66 , C12N15/10 , A61K39/125 , A61K39/00
CPC分类号： A61K39/125 , C12N15/102 , C12N15/66 , A61K2039/5252 , A61K2039/53 , C12N7/00 , C12N2770/32034
摘要： The disclosure provides a recombinant nucleic acid of Seneca valley virus, a recombinant vaccine strain and preparation method and use thereof, and relates to the technical field of genetic engineering. The disclosure provides the recombinant nucleic acid of Seneca valley virus, recombinant Seneca valley virus comprising the recombinant nucleic acid, recombinant Seneca valley virus encoded by the recombinant nucleic acid, recombinant Seneca valley virus vaccine strain comprising the recombinant Seneca valley virus and preparation method and use thereof. According to the disclosure, a vaccine strain characterized by high antigen production capacity, remarkably reduced pathogenicity (even having no pathogenicity to pigs), strong antibody induction activity, high immune protection rate is prepared. The vaccine strain remarkably improves the biological safety and can be used for preventing and controlling Seneca valley virus in China and the neighboring countries.
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公开(公告)号：US10894081B2
公开(公告)日：2021-01-19
申请号：US16346496
申请日：2018-03-23
发明人： Haixue Zheng , Fan Yang , Zixiang Zhu , Weijun Cao , Hong Tian , Keshan Zhang , Dan Li , Ye Jin , Jianhong Guo , Jijun He , Xuepeng Cai , Xiangtao Liu
IPC分类号： A61K39/135 , C12N7/00 , A61K39/00
摘要： The present disclosure relates to a foot-and-mouth disease virus vaccine composition, especially a recombinant bivalent vaccine composition against type O and type A foot-and-mouth disease viruses. The present disclosure further relates to a method for preparing the foot-and-mouth disease virus vaccine composition, and a use of the foot-and-mouth disease virus vaccine composition in preparing medicines for preventing and/or controlling foot-and-mouth disease in animals.
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公开(公告)号：US11883411B2
公开(公告)日：2024-01-30
申请号：US17895390
申请日：2022-08-25
发明人： Keshan Zhang , Haixue Zheng , Huimei Cui , Bo Yang , Hong Tian , Zixiang Zhu , Tao Feng , Fan Yang , Weijun Cao , Xusheng Ma , Yi Ru , Jianhong Guo , Xiangtao Liu
IPC分类号： A61K31/5377 , A61P31/20
CPC分类号： A61K31/5377 , A61P31/20
摘要： The present disclosure belongs to the technical field of African swine fever (ASF) treatment, in particular to use of a compound aprepitant in prevention or treatment of the ASF. In the present disclosure, it is found that the compound aprepitant can significantly inhibit replication of an African swine fever virus (ASFV); in addition, it is found that the aprepitant inhibits transcription and protein expression of D1133L, and reduces transcription and protein expression levels of p30 and p72, preventing virus invasion on host cells. Therefore, the compound aprepitant can be used to inhibit early and late infection of the ASFV. Accordingly, the compound aprepitant can be used to prevent or treat the ASF.
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公开(公告)号：US11987797B2
公开(公告)日：2024-05-21
申请号：US18057588
申请日：2022-11-21
发明人： Haixue Zheng , Keshan Zhang , Ting Zhang , Tao Feng , Bo Yang , Xing Yang , Xijuan Shi , Hong Tian , Yi Ru , Fan Yang , Zixiang Zhu , Jianhong Guo , Jijun He , Xiangtao Liu
CPC分类号： C12N15/65 , C12N7/00 , C12N15/63 , C12N2710/12021 , C12N2710/12022
摘要： The present disclosure belongs to the technical field of biology, and in particular relates to an attenuated strain of African swine fever virus (ASFV) with IPTG-induced deletion of a D1133L gene and use thereof. In the present disclosure, it is firstly found that the D1133L protein of ASFV can inhibit production of IFN-β and downstream cytokines ISG-15 and ISG-56, and can be used as an immunosuppressant with a relatively strong immunosuppressive effect. In addition, the attenuated strain of ASFV with IPTG-induced deletion of the D1133L gene is constructed. Specifically, a screening expression cassette is inserted into a position before the non-structural protein gene D1133L of the ASFV using an Escherichia coli lac operator-repressor system, to obtain a recombinant virus. In the presence of the IPTG, the recombinant virus has similar characteristics to a wild-type virus; and in the absence of the IPTG, the expression of the D1133L protein is inhibited.
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公开(公告)号：US20220031832A1
公开(公告)日：2022-02-03
申请号：US17328135
申请日：2021-05-24
发明人： Haixue Zheng , Fan Yang , Zixiang Zhu , Weijun Cao , Hong Tian , Keshan Zhang , Ting Wei , Min Zheng , Wei Zhang , Wen Dang , Xusheng Ma , Dan Li , Yi Ru , Jijun He , Jianhong Guo , Xiangtao Liu
IPC分类号： A61K39/125 , C12N15/10 , C12N15/66
摘要： The disclosure provides a recombinant nucleic acid of Seneca valley virus, a recombinant vaccine strain and preparation method and use thereof, and relates to the technical field of genetic engineering. The disclosure provides the recombinant nucleic acid of Seneca valley virus, recombinant Seneca valley virus comprising the recombinant nucleic acid, recombinant Seneca valley virus encoded by the recombinant nucleic acid, recombinant Seneca valley virus vaccine strain comprising the recombinant Seneca valley virus and preparation method and use thereof. According to the disclosure, a vaccine strain characterized by high antigen production capacity, remarkably reduced pathogenicity (even having no pathogenicity to pigs), strong antibody induction activity, high immune protection rate is prepared. The vaccine strain remarkably improves the biological safety and can be used for preventing and controlling Seneca valley virus in China and the neighboring countries.
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