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公开(公告)号：US11883411B2
公开(公告)日：2024-01-30
申请号：US17895390
申请日：2022-08-25
发明人： Keshan Zhang , Haixue Zheng , Huimei Cui , Bo Yang , Hong Tian , Zixiang Zhu , Tao Feng , Fan Yang , Weijun Cao , Xusheng Ma , Yi Ru , Jianhong Guo , Xiangtao Liu
IPC分类号： A61K31/5377 , A61P31/20
CPC分类号： A61K31/5377 , A61P31/20
摘要： The present disclosure belongs to the technical field of African swine fever (ASF) treatment, in particular to use of a compound aprepitant in prevention or treatment of the ASF. In the present disclosure, it is found that the compound aprepitant can significantly inhibit replication of an African swine fever virus (ASFV); in addition, it is found that the aprepitant inhibits transcription and protein expression of D1133L, and reduces transcription and protein expression levels of p30 and p72, preventing virus invasion on host cells. Therefore, the compound aprepitant can be used to inhibit early and late infection of the ASFV. Accordingly, the compound aprepitant can be used to prevent or treat the ASF.
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公开(公告)号：US20220031832A1
公开(公告)日：2022-02-03
申请号：US17328135
申请日：2021-05-24
发明人： Haixue Zheng , Fan Yang , Zixiang Zhu , Weijun Cao , Hong Tian , Keshan Zhang , Ting Wei , Min Zheng , Wei Zhang , Wen Dang , Xusheng Ma , Dan Li , Yi Ru , Jijun He , Jianhong Guo , Xiangtao Liu
IPC分类号： A61K39/125 , C12N15/10 , C12N15/66
摘要： The disclosure provides a recombinant nucleic acid of Seneca valley virus, a recombinant vaccine strain and preparation method and use thereof, and relates to the technical field of genetic engineering. The disclosure provides the recombinant nucleic acid of Seneca valley virus, recombinant Seneca valley virus comprising the recombinant nucleic acid, recombinant Seneca valley virus encoded by the recombinant nucleic acid, recombinant Seneca valley virus vaccine strain comprising the recombinant Seneca valley virus and preparation method and use thereof. According to the disclosure, a vaccine strain characterized by high antigen production capacity, remarkably reduced pathogenicity (even having no pathogenicity to pigs), strong antibody induction activity, high immune protection rate is prepared. The vaccine strain remarkably improves the biological safety and can be used for preventing and controlling Seneca valley virus in China and the neighboring countries.
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公开(公告)号：US10894081B2
公开(公告)日：2021-01-19
申请号：US16346496
申请日：2018-03-23
发明人： Haixue Zheng , Fan Yang , Zixiang Zhu , Weijun Cao , Hong Tian , Keshan Zhang , Dan Li , Ye Jin , Jianhong Guo , Jijun He , Xuepeng Cai , Xiangtao Liu
IPC分类号： A61K39/135 , C12N7/00 , A61K39/00
摘要： The present disclosure relates to a foot-and-mouth disease virus vaccine composition, especially a recombinant bivalent vaccine composition against type O and type A foot-and-mouth disease viruses. The present disclosure further relates to a method for preparing the foot-and-mouth disease virus vaccine composition, and a use of the foot-and-mouth disease virus vaccine composition in preparing medicines for preventing and/or controlling foot-and-mouth disease in animals.
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公开(公告)号：US11952401B2
公开(公告)日：2024-04-09
申请号：US17375203
申请日：2021-07-14
发明人： Haixue Zheng , Fan Yang , Zixiang Zhu , Xiangle Zhang , Weijun Cao , Congcong Wang , Kangli Li , Huisheng Liu , Hong Tian , Keshan Zhang , Xiangtao Liu
IPC分类号： C07K14/005 , A61K39/00 , A61K39/135 , A61P31/14 , A61P37/06 , C12N7/00
CPC分类号： C07K14/005 , A61K39/135 , A61P31/14 , A61P37/06 , C12N7/00 , A61K2039/525 , A61K2039/552 , C12N2770/32121 , C12N2770/32122 , C12N2770/32134 , C12N2770/32152 , C12N2770/32171
摘要： The present disclosure belongs to the technical field of biological products for veterinary medicine, and specifically relates to a recombinant foot-and-mouth disease virus (FMDV) with a reduced immunosuppressive activity, a preparation method and use thereof, and a recombinant vaccine strain. According to the present disclosure, it is firstly discovered that FMDV 3B protein has an immunosuppressive function, and key sites for exerting the immunosuppressive function are found. A recombinant FMDV vaccine strain with a lost immunosuppressive function in FMDV 3B protein is constructed by introducing amino acid mutations into three repeated copies of FMDV 3B protein.
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公开(公告)号：US11883482B2
公开(公告)日：2024-01-30
申请号：US17328135
申请日：2021-05-24
发明人： Haixue Zheng , Fan Yang , Zixiang Zhu , Weijun Cao , Hong Tian , Keshan Zhang , Ting Wei , Min Zheng , Wei Zhang , Wen Dang , Xusheng Ma , Dan Li , Yi Ru , Jijun He , Jianhong Guo , Xiangtao Liu
IPC分类号： C12N7/00 , C12N15/66 , C12N15/10 , A61K39/125 , A61K39/00
CPC分类号： A61K39/125 , C12N15/102 , C12N15/66 , A61K2039/5252 , A61K2039/53 , C12N7/00 , C12N2770/32034
摘要： The disclosure provides a recombinant nucleic acid of Seneca valley virus, a recombinant vaccine strain and preparation method and use thereof, and relates to the technical field of genetic engineering. The disclosure provides the recombinant nucleic acid of Seneca valley virus, recombinant Seneca valley virus comprising the recombinant nucleic acid, recombinant Seneca valley virus encoded by the recombinant nucleic acid, recombinant Seneca valley virus vaccine strain comprising the recombinant Seneca valley virus and preparation method and use thereof. According to the disclosure, a vaccine strain characterized by high antigen production capacity, remarkably reduced pathogenicity (even having no pathogenicity to pigs), strong antibody induction activity, high immune protection rate is prepared. The vaccine strain remarkably improves the biological safety and can be used for preventing and controlling Seneca valley virus in China and the neighboring countries.
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