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    Methylsulfonyl-benzoic acid derivatives
    1.
    发明授权
    Methylsulfonyl-benzoic acid derivatives 失效
    甲磺酰基 - 苯甲酸衍生物

    公开(公告)号：US3898266A

    公开(公告)日：1975-08-05

    申请号：US47883374

    申请日：1974-06-12

    申请人： LEO PHARM PROD LTD

    发明人： FEIT PETER WERNER ,  NIELSEN OLE BENT TVAERMOSE ,  BRUUN HERTA

    IPC分类号： C07C319/14 ,  A61K20060101 ,  A61K31/10 ,  A61K31/19 ,  C07C20060101 ,  C07C67/00 ,  C07C313/00 ,  C07C313/04 ,  C07C315/00 ,  C07C317/14 ,  C07C317/44 ,  C07C317/46 ,  C07C323/65 ,  C07C147/06

    CPC分类号： C07C313/04 ,  C07C317/00 ,  C07C323/00 ,  Y10S514/869

    摘要： The present invention relates to a series of new compounds, their salts and esters and to methods for the preparation of the compounds having the general formula:

    IN WHICH R1 represents a straight or branched C1-C6 alkyl, alkenyl or alkynyl radical, or a C1-C3 alkyl radical substituted with phenyl, halophenyl, trifluoromethylphenyl, (lower alkoxy)phenyl, or with a 5-membered or 6-membered heterocyclic ring containing not more than two heteroatoms selected from the group consisting of oxygen, sulphur and nitrogen; R2 stands for a phenyl radical, optionally being substituted with halogen, lower alkyl, hydroxy, or lower alkoxy; X stands for oxygen, sulphur or C O; Y stands for oxygen, sulphur or a methylene radical. The compounds of the invention which are valuable in the human and veterinary practice, possess an outstanding diuretic and saluretic activity.

    摘要翻译： 本发明涉及一系列新化合物，其盐和酯，以及制备具有以下通式的化合物的方法：其中R1表示直链或支链C1-C6烷基，烯基或炔基或C1 被苯基，卤代苯基，三氟甲基苯基，（低级烷氧基）苯基或与含有不多于两个选自氧，硫和氮的杂原子的5员或6元杂环取代的-C 3烷基; R2代表苯基，任选被卤素，低级烷基，羟基或低级烷氧基取代; X代表氧，硫或C = O; Y代表氧，硫或亚甲基。

    Benzoic acid derivatives
    2.
    发明授权
    Benzoic acid derivatives 失效
    苯甲酸衍生物

    公开(公告)号：US3903146A

    公开(公告)日：1975-09-02

    申请号：US40939373

    申请日：1973-10-25

    申请人： LEO PHARM PROD LTD

    发明人： FEIT PETER WERNER ,  NIELSEN OLE BENT TVAERMOSE

    IPC分类号： C07C205/58 ,  C07C205/61 ,  C07C275/42 ,  C07C149/42

    CPC分类号： C07C275/42 ,  C07C205/58 ,  C07C205/61 ,  C07C323/00

    摘要： The invention relates to a series of new compounds, to salts of these compounds and to methods for the preparation of the compounds. The new compounds have the general formula:

    IN WHICH R1 is selected from the group consisting of alkyl radicals with from 3 to 8 carbon atoms in the carbon chain; mononuclear aromatically and mono-nuclear heterocyclically substituted methyl and ethyl; A is selected from the group consisting of unsubstituted and substituted phenoxy radicals, phenylthio radicals, benzoyl, benzyl and Alpha -hydroxybenzyl radicals; R2 is selected from the group consisting of hydrogen, lower alkyl groups, lower alkoxy groups, unsubstituted and monoand di-substituted amine groups. In particular the compounds of formula (I) have a pronounced diuretic and/or saluretic activity which is surprising in view of the chemical structure and the absence of a sulphamyl group.

    摘要翻译： 本发明涉及一系列新化合物，这些化合物的盐和制备该化合物的方法。 新化合物具有以下通式：

    Benzoic acid derivatives
    5.
    发明授权
    Benzoic acid derivatives 失效
    苯甲酸衍生物

    公开(公告)号：US3896165A

    公开(公告)日：1975-07-22

    申请号：US40939473

    申请日：1973-10-25

    申请人： LEO PHARM PROD LTD

    发明人： FEIT PETER WERNER ,  NIELSEN OLE BENT TVAERMOSE

    IPC分类号： C07C205/58 ,  C07C205/61 ,  C07C233/00 ,  C07C275/42 ,  C07C103/12

    CPC分类号： C07C275/42 ,  C07C205/58 ,  C07C205/61 ,  C07C323/00

    摘要： The invention relates to a series of new compounds, to salts of these compounds and to methods for the preparation of the compounds. The new compounds have the general formula:

    IN WHICH R1 is selected from the group consisting of alkyl radicals with from 3 to 8 carbon atoms in the carbon chain; mononuclear aromatically and mono-nuclear heterocyclically substituted methyl and ethyl; A is selected from the group consisting of unsubstituted and substituted phenoxy radicals, phenylthio radicals, benzoyl, benzyl and Alpha -hydroxybenzyl radicals; R2 is selected from the group consisting of hydrogen, lower alkyl groups, lower alkoxy groups, unsubstituted and monoand di-substituted amino groups. In particular the compounds of formula (I) have a pronounced diuretic and/or saluretic activity which is surprising in view of the chemical structure and the absence of a sulphamyl group.