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1.发明授权Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them 有权中氮茚化合物，其制备方法和含有它们的药物组合物公开(公告)号：US09120791B2
公开(公告)日：2015-09-01
申请号：US14374071
申请日：2013-01-23
发明人： Thierry Le Diguarher , Patrick Casara , Jérôme-Benoît Starck , Jean-Michel Henlin , James Edward Paul Davidson , James Brooke Murray , Christopher John Graham , I-Jen Chen , Olivier Geneste , John Hickman , Stéphane Depil , Arnaud Le Tiran , Miklos Nyerges , Guillaume De Nanteuil
IPC分类号： C07D471/00 , A61K31/475 , C07D471/04 , C07D487/04 , C07D491/052 , C07D207/30 , C07D211/06 , C07D211/80 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , A61N5/10 , C07D498/04
CPC分类号： A61K31/5377 , A61K31/4725 , A61K31/475 , A61K31/496 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , A61N5/10 , A61N5/1001 , C07D207/30 , C07D211/06 , C07D211/80 , C07D471/00 , C07D471/04 , C07D487/04 , C07D491/052 , C07D498/04
摘要： Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R1, R2, R3, R4, R5, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
摘要翻译： 式（I）化合物：其中R a，R b，R c，R d，R 1，R 2，R 3，R 4，R 5，X，Y和Het如说明书中所定义。 含有该物质的药物可用于治疗涉及细胞凋亡缺陷的病症，如癌症，自身免疫疾病和免疫系统疾病。
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公开(公告)号：US09603854B2
公开(公告)日：2017-03-28
申请号：US14799840
申请日：2015-07-15
发明人： Thierry Le Diguarher , Patrick Casara , Jérôme-Benoît Starck , Jean-Michel Henlin , James Edward Paul Davidson , James Brooke Murray , Christopher John Graham , I-Jen Chen , Olivier Geneste , John Hickman , Stéphane Depil , Arnaud Le Tiran , Miklos Nyerges , Guillaume De Nanteuil
IPC分类号： C07D471/04 , A61K31/4725 , C07D487/04 , C07D491/052 , A61K31/553 , A61N5/10 , C07D471/00 , C07D207/30 , C07D211/06 , C07D211/80 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K45/06 , C07D498/04
CPC分类号： A61K31/5377 , A61K31/4725 , A61K31/475 , A61K31/496 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , A61N5/10 , A61N5/1001 , C07D207/30 , C07D211/06 , C07D211/80 , C07D471/00 , C07D471/04 , C07D487/04 , C07D491/052 , C07D498/04
摘要： Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R1, R2, R3, R4, R5, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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公开(公告)号：US20150051189A1
公开(公告)日：2015-02-19
申请号：US14374071
申请日：2013-01-23
发明人： Thierry Le Diguarher , Patrick Casara , Jérôme-Benoît Starck , Jean-Michel Henlin , James Edward Paul Davidson , James Brooke Murray , Christopher John Graham , I-Jen Chen , Olivier Geneste , John Hickman , Stéphane Depil , Arnaud Le Tiran , Miklos Nyerges , Guillaume De Nanteuil
IPC分类号： C07D471/04 , A61K45/06 , A61K31/496 , A61K31/553 , A61N5/10 , C07D498/04 , A61K31/5383 , A61K31/55 , A61K31/541 , A61K31/475 , A61K31/5377 , C07D487/04
CPC分类号： A61K31/5377 , A61K31/4725 , A61K31/475 , A61K31/496 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , A61N5/10 , A61N5/1001 , C07D207/30 , C07D211/06 , C07D211/80 , C07D471/00 , C07D471/04 , C07D487/04 , C07D491/052 , C07D498/04
摘要： Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R1, R2, R3, R4, R5, X, Y and Het are as defined in the description.Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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4.发明授权公开(公告)号：US09598427B2
公开(公告)日：2017-03-21
申请号：US14797532
申请日：2015-07-13
发明人： Arnaud Le Tiran , Thierry Le Diguarher , Jérôme-Benoît Starck , Jean-Michel Henlin , Anne-Françoise Guillouzic , Guillaume De Nanteuil , Olivier Geneste , Imre Fejes , Janos Tatai , Miklos Nyerges , James Edward Paul Davidson , James Brooke Murray , I-Jen Chen , Didier Durand
IPC分类号： C07D401/14 , A61K31/47 , C07D491/107 , C07D405/14 , C07D401/10 , C07D471/04 , C07D491/10 , C07D498/04 , A61K45/06 , A61K31/4725 , A61K31/5377 , A61K31/496 , A61K31/506 , A61K31/5383 , C07D498/14 , A61K9/20
CPC分类号： A61K31/5383 , A61K9/2059 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/10 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D498/14 , A61K2300/00
摘要： Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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5.发明授权Pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them 有权吡咯化合物，其制备方法和含有它们的药物组合物公开(公告)号：US09108983B2
公开(公告)日：2015-08-18
申请号：US14336311
申请日：2014-07-21
发明人： Arnaud Le Tiran , Thierry Le Diguarher , Jérôme-Benoît Starck , Jean-Michel Henlin , Anne-Françoise Guillouzic , Guillaume De Nanteuil , Olivier Geneste , Imre Fejes , Janos Tatai , Miklos Nyerges , James Edward Paul Davidson , James Brooke Murray , I-Jen Chen , Didier Durand
IPC分类号： C07D401/04 , C07D401/10 , A61K31/4725 , C07D491/107 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/10 , C07D498/04 , A61K45/06 , A61K31/5377 , A61K31/496 , A61K31/506 , A61K31/5383 , C07D498/14
CPC分类号： A61K31/5383 , A61K9/2059 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/10 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D498/14 , A61K2300/00
摘要： Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
摘要翻译： 式（I）化合物：其中A1，A2，Ra，Rb，Rc，Rd，R3，R4，R5和T如说明书中所定义。 含有该物质的药物可用于治疗涉及细胞凋亡缺陷的病症，如癌症，自身免疫疾病和免疫系统疾病。
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