公开(公告)号：US10927097B2

公开(公告)日：2021-02-23

申请号：US14913132

申请日：2014-08-21

申请人： LG CHEM, LTD.

发明人： Heui Sul Park ,  Sun Young Koo ,  Hyoung Jin Kim ,  Sung Bae Lee ,  Hyo Shin Kwak ,  Vasily Artemov ,  Soon Ha Kim

IPC分类号： C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D401/14 ,  C07D417/06 ,  C07D417/14 ,  C07D487/04 ,  C07D209/12 ,  C07D209/14 ,  C07D401/04 ,  C07D403/04 ,  C07D209/08

摘要： The present application relates to an indole compound represented by formula (1): a pharmaceutically acceptable salt or isomer thereof, a composition for prevention or treatment of necrosis and necrosis-associated diseases, and a method for preparing the composition, the composition comprising the indole compound or the pharmaceutically acceptable salt or isomer thereof as an active ingredient.

公开(公告)号：US10322135B2

公开(公告)日：2019-06-18

申请号：US15441998

申请日：2017-02-24

申请人： LG CHEM, LTD.

发明人： Soon Ha Kim ,  Hyoung Jin Kim ,  Heui Sul Park ,  Seon Yeong Gu ,  Hyo Shin Kwak ,  Du Hee Park ,  Hyo Soo Kim ,  Hyun Jai Cho ,  Ji Hyun Kim ,  Ju Young Kim ,  Kwang Min Park

IPC分类号： A61K31/541 ,  A61K8/49 ,  A61K31/404 ,  C07D417/14 ,  A61K31/4184 ,  A61Q19/00 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  A61K31/427 ,  A61K31/496 ,  A61K31/497

摘要： The present invention relates to a pharmaceutical composition comprising a compound of formula (1), (2) or (3) as defined in the specification for the prevention or treatment of diseases associated with oxidative stress, mitochondria dysfunction, hypoxic injury, necrosis and/or ischemic reperfusion injury, and a cosmetic composition comprising an indole compound having an antioxidant effect.

公开(公告)号：US09868731B2

公开(公告)日：2018-01-16

申请号：US14913140

申请日：2014-08-21

申请人： LG CHEM, LTD.

发明人： Heui Sul Park ,  Sun Young Koo ,  Hyoung Jin Kim ,  Sung Bae Lee ,  Hyo Shin Kwak ,  Seung Yup Paek ,  Soon Ha Kim

IPC分类号： C07D417/12 ,  C07D403/12 ,  C07D405/14 ,  C07D403/06 ,  C07D209/42 ,  A61K31/4045 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14

CPC分类号： C07D417/12 ,  A61K31/4045 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D209/42 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14

摘要： The present invention relates to an indole amide compound represented by formula (1), a pharmaceutically acceptable salt or isomer thereof, a composition for prevention or treatment of necrosis and necrosis-associated diseases, and a method for preparing the composition, the composition comprising the indole compound or the pharmaceutically acceptable salt or isomer thereof as an active ingredient.