公开(公告)号：US20190224684A1

公开(公告)日：2019-07-25

申请号：US16370586

申请日：2019-03-29

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Hwee Tian NG ,  Huei YEO ,  Wei Hsien CHOO

IPC: B01L7/00 ,  C12Q1/686

Abstract: The present invention relates to a thermal cycler for the carrying out of chemical or biological reactions, such as PCR or other nucleic acid amplification reactions, that is segmented with a plurality of reaction vessel receiving elements. The reaction vessel receiving elements are thermally isolated from each other and provide an airtight seal to prevent liquids or moisture from penetrating below the reaction vessel receiving elements. The reaction vessel receiving elements have several recesses arranged in a pattern to receive the reaction vessels of a single standard microtiter plate and the segmented thermal cycler has a system for independently heating and cooling each of the reaction vessel receiving elements.

公开(公告)号：US20210214771A1

公开(公告)日：2021-07-15

申请号：US17151657

申请日：2021-01-18

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Mingsong CHEN ,  Kuan Moon BOO ,  Tiong Han TOH ,  Mauro AGUANNO ,  Soo Yong LAU ,  Huei YEO ,  Wei Fuh TEO

IPC: C12Q1/686 ,  G01N21/64 ,  G02B21/24 ,  B01L7/00

Abstract: An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The may instrument further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.