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    OPTICAL SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS
    1.
    发明申请
    OPTICAL SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS 审中-公开

    公开(公告)号：US20170307529A1

    公开(公告)日：2017-10-26

    申请号：US15643626

    申请日：2017-07-07

    申请人： LIFE TECHNOLOGIES CORPORATION

    发明人： Kevin MAHER ,  Mingsong CHEN ,  Jacob K. FREUDENTHAL ,  Kuan Moon BOO ,  Soo Yong LAU ,  David FORTESCUE ,  Ming SHEN ,  Woon Liang Terence SOH

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6486 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/062

    摘要： An instrument for processing and/or measuring a biological process contains an excitation source, a sample holder, an optical sensor, an excitation optical system, and an emission optical system. The sample holder is configured to receive a plurality of biological samples. The optical sensor is configured to receive an emission from the biological samples. The excitation optical system is disposed along an excitation optical path and is configured to direct the electromagnetic radiation from the excitation source to the biological samples. The emission optical system is disposed along an emission optical path and is configured to direct electromagnetic emissions from the biological samples to the optical sensor. The instrument further contains a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths. The plurality of filter components includes a first filter assembly characterized by a first optical power and a first filter having a first filter function, the first filter function characterized by at least one of a first low-pass wavelength or a first high-pass wavelength. The second filter assembly is characterized by a second optical power and a second filter having a second filter function, the second filter function comprising at least one of a second low-pass wavelength that is different than the first low-pass wavelength or a second high-pass wavelength that is different than the first high-pass wavelength.

    OPTICAL SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS
    3.
    发明申请
    OPTICAL SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS 有权

    公开(公告)号：US20220412890A1

    公开(公告)日：2022-12-29

    申请号：US17825222

    申请日：2022-05-26

    申请人： LIFE TECHNOLOGIES CORPORATION

    发明人： Kevin MAHER ,  Mingsong CHEN ,  Jacob K. FREUDENTHAL ,  Kuan Moon BOO ,  Soo Yong LAU ,  David FORTESCUE ,  Ming SHEN ,  Woon Liang Terence SOH

    IPC分类号： G01N21/64

    摘要： An instrument for processing and/or measuring a biological process comprises a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths. The plurality of filter components includes a first filter assembly characterized by a first optical power and a first filter having a first filter function, the first filter function characterized by at least one of a first low-pass wavelength or a first high-pass wavelength. The second filter assembly is characterized by a second optical power and a second filter having a second filter function, the second filter function comprising at least one of a second low-pass wavelength that is different than the first low-pass wavelength or a second high-pass wavelength that is different than the first high-pass wavelength.

    Optical Systems and Methods for Biological Analysis
    4.
    发明申请
    Optical Systems and Methods for Biological Analysis 审中-公开
    光学系统和生物分析方法

    公开(公告)号：US20160011115A1

    公开(公告)日：2016-01-14

    申请号：US14766725

    申请日：2014-02-24

    申请人： LIFE TECHNOLOGIES CORPORATION

    发明人： Mingsong CHEN ,  Mauro AGUANNO ,  Kuan Moon BOO ,  Woon Liang Terence SOH ,  Jacob K. FREUDENTHAL ,  Jeffrey A. MARKS

    IPC分类号： G01N21/64 ,  G01N21/03

    摘要： An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.

    摘要翻译： 用于处理和/或测量生物过程的仪器包括样品处理系统，激发源，激发光学系统，光学传感器和发射光学系统。 样品处理系统被配置为保持第一样品保持器和第二样品保持器，其中样品池的数量对于每个样品保持器是不同的，或者第一样品池的特征尺寸与第二样品保持器的特征尺寸不同。 仪器还包括激发源温度控制器，其包括耦合到激发源的温度传感器。 温度控制器被配置为当第一样本保持器被仪器保持时产生第一目标温度，并且当第二样本保持器被仪器保持时产生第二目标温度。

    SYSTEMS AND METHODS FOR ASSESSING BIOLOGICAL SAMPLES
    5.
    发明申请
    SYSTEMS AND METHODS FOR ASSESSING BIOLOGICAL SAMPLES 有权

    公开(公告)号：US20210214771A1

    公开(公告)日：2021-07-15

    申请号：US17151657

    申请日：2021-01-18

    申请人： LIFE TECHNOLOGIES CORPORATION

    发明人： Mingsong CHEN ,  Kuan Moon BOO ,  Tiong Han TOH ,  Mauro AGUANNO ,  Soo Yong LAU ,  Huei YEO ,  Wei Fuh TEO

    IPC分类号： C12Q1/686 ,  G01N21/64 ,  G02B21/24 ,  B01L7/00

    摘要： An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The may instrument further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.

    SYSTEMS AND METHODS FOR ASSESSING BIOLOGICAL SAMPLES
    6.
    发明申请
    SYSTEMS AND METHODS FOR ASSESSING BIOLOGICAL SAMPLES 审中-公开
    用于评估生物样本的系统和方法

    公开(公告)号：US20160230210A1

    公开(公告)日：2016-08-11

    申请号：US15017488

    申请日：2016-02-05

    申请人： LIFE TECHNOLOGIES CORPORATION

    发明人： Mingsong CHEN ,  Kuan Moon BOO ,  Tiong Han TOH ,  Mauro AGUANNO ,  Soo Yong LAU ,  Huei Steven YEO ,  Wei Fuh TEO

    IPC分类号： C12Q1/68 ,  B01L7/00 ,  G01N21/64

    CPC分类号： C12Q1/686 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/168 ,  B01L2300/18 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/6458 ,  G01N2021/6463 ,  G02B21/244

    摘要： An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The may instrument further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.

    摘要翻译： 用于生物分析的仪器包括基座，激发源，光学传感器，激发光学系统和发射光学系统。 基座被配置为接收包括多个生物样品的样品架。 光学传感器被配置为响应于激发源接收来自生物样品的发射。 该仪器还可以包括由透镜壳体包围的传感器透镜和包括与透镜壳体接合的齿轮的聚焦机构，聚焦机构可在外壳外部接近以调节焦点。 仪器还可以包括沿着发射光路设置的传感器孔径和设置成与传感器孔径配合的阻挡结构，使得来自样品保持器附近的被照射表面的反射的辐射没有被也不是的光学传感器接收 反射出仪器的另一个表面。