公开(公告)号：US20190126281A1

公开(公告)日：2019-05-02

申请号：US16116801

申请日：2018-08-29

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Yong CHU ,  Jeffrey MARKS ,  Jacob FREUDENTHAL ,  Mingsong CHEN ,  Tiong Han TOH ,  Mauro AGUANNO ,  Lik Seng LAU ,  Lian Seng LOH ,  Kok Siong TEO ,  Zeng Wei CHU ,  Xin MATHERS ,  Michael UY ,  Huei Steven YEO ,  Kuan Moon BOO ,  Way Xuang LEE ,  Chin Yong KOO ,  Wei Fuh TEO ,  Soo Yong LAU ,  Hon Siu SHIN ,  Zeqi TAN ,  Thomas WESSEL ,  David WOO

IPC: B01L7/00 ,  G01N21/27 ,  G01N21/64 ,  C12Q1/6806 ,  G01N35/02

Abstract: A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.

公开(公告)号：US20210214771A1

公开(公告)日：2021-07-15

申请号：US17151657

申请日：2021-01-18

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Mingsong CHEN ,  Kuan Moon BOO ,  Tiong Han TOH ,  Mauro AGUANNO ,  Soo Yong LAU ,  Huei YEO ,  Wei Fuh TEO

IPC: C12Q1/686 ,  G01N21/64 ,  G02B21/24 ,  B01L7/00

Abstract: An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The may instrument further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.

公开(公告)号：US20160230210A1

公开(公告)日：2016-08-11

申请号：US15017488

申请日：2016-02-05

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Mingsong CHEN ,  Kuan Moon BOO ,  Tiong Han TOH ,  Mauro AGUANNO ,  Soo Yong LAU ,  Huei Steven YEO ,  Wei Fuh TEO

IPC: C12Q1/68 ,  B01L7/00 ,  G01N21/64

CPC classification number: C12Q1/686 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/168 ,  B01L2300/18 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/6458 ,  G01N2021/6463 ,  G02B21/244

Abstract: An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The may instrument further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.

Abstract translation: 用于生物分析的仪器包括基座，激发源，光学传感器，激发光学系统和发射光学系统。 基座被配置为接收包括多个生物样品的样品架。 光学传感器被配置为响应于激发源接收来自生物样品的发射。 该仪器还可以包括由透镜壳体包围的传感器透镜和包括与透镜壳体接合的齿轮的聚焦机构，聚焦机构可在外壳外部接近以调节焦点。 仪器还可以包括沿着发射光路设置的传感器孔径和设置成与传感器孔径配合的阻挡结构，使得来自样品保持器附近的被照射表面的反射的辐射没有被也不是的光学传感器接收 反射出仪器的另一个表面。

公开(公告)号：US20150231636A1

公开(公告)日：2015-08-20

申请号：US14613496

申请日：2015-02-04

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Chee Kiong Lim ,  Way Xuang LEE ,  Wuh Ken LOH ,  Chee Wee CHING ,  Chin Yong KOO ,  Siew Ying KOH ,  Tiong Han TOH ,  Kuan Moon BOO ,  Soo Yong LAU

IPC: B01L7/00 ,  B01L3/00 ,  C12Q1/68

CPC classification number: B01L7/52 ,  B01L2200/147 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2300/1822 ,  B01L2300/1883 ,  C12Q1/6806

Abstract: In one aspect, a thermal cycler system including a sample block and a thermoelectric device is disclosed. In various embodiments, the sample block has a first surface configured to receive a plurality of reaction vessels and an opposing second surface. In various embodiments the thermoelectric device is operably coupled to the second surface of the sample block. In various embodiments a thermal control unit is provided. In various embodiments the thermal control unit includes a computer processing unit. In various embodiments the thermal control unit includes an electrical current source. In various embodiments the thermal control unit also includes an electrical interface portion configured to connect the thermoelectric device with the electrical current source by way of an electrical cable. In various embodiments the thermal control unit is oriented in a different plane than the sample block and thermoelectric cooler.

Abstract translation: 一方面，公开了一种包括样品块和热电装置的热循环仪系统。 在各种实施例中，样品块具有构造成容纳多个反应容器和相对的第二表面的第一表面。 在各种实施例中，热电装置可操作地耦合到样品块的第二表面。 在各种实施例中，提供了热控制单元。 在各种实施例中，热控制单元包括计算机处理单元。 在各种实施例中，热控制单元包括电流源。 在各种实施例中，热控制单元还包括被配置为通过电缆将热电装置与电流源连接的电接口部分。 在各种实施例中，热控制单元定向在与样品块和热电冷却器不同的平面中。