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    METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR NUCLEIC ACID SEQUENCING
    1.
    发明申请
    METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR NUCLEIC ACID SEQUENCING 审中-公开

    公开(公告)号：US20190277799A1

    公开(公告)日：2019-09-12

    申请号：US16271979

    申请日：2019-02-11

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Melville DAVEY ,  Simon CAWLEY ,  Alan WILLIAMS

    IPC: G01N27/414 ,  G16B30/00

    Abstract: A method for nucleic acid sequencing includes receiving a plurality of signals indicative of a parameter measured for a plurality of defined spaces, at least some of the defined spaces including one or more sample nucleic acids, the signals being responsive to a plurality of nucleotide flows introducing nucleotides to the defined spaces; determining, for at least some of the defined spaces, whether the defined space includes a sample nucleic acid; processing, for at least some of the defined spaces determined to include a sample nucleic acid, the received signals to improve a quality of the received signals; and predicting a plurality of nucleotide sequences corresponding to respective sample nucleic acids for the defined spaces based on the processed signals and the nucleotide flows.

    Methods and Apparatuses for Estimating Parameters in a Predictive Model for Use in Sequencing-by-Synthesis
    3.
    发明申请
    Methods and Apparatuses for Estimating Parameters in a Predictive Model for Use in Sequencing-by-Synthesis 审中-公开
    用于按序排序合成的预测模型中估计参数的方法和装置

    公开(公告)号：US20140051584A1

    公开(公告)日：2014-02-20

    申请号：US13967665

    申请日：2013-08-15

    Applicant: Life Technologies Corporation

    Inventor： Melville DAVEY ,  Michael MEYER ,  Marcin SIKORA ,  Simon CAWLEY ,  Kirk PASTORIAN

    IPC: C12Q1/68

    CPC classification number: C12Q1/6874 ,  G06F19/10 ,  C12Q2537/165

    Abstract: A method of estimating a parameter related to sequencing of a sample nucleic acid template includes: receiving signal data relating to nucleotide incorporation events resulting from a series of flows of nucleotides onto an array of wells including (i) a first well containing the sample nucleic acid template and (ii) a plurality of other sample-containing wells; determining sequence information for the sample nucleic acid template using signal data from the first well; and constructing a phase-state model for a set of nucleotide flows that contributed at least in part to the sequence information, wherein the model includes a signal correction parameter that is determined using signal data from the plurality of other sample-containing wells.

    Abstract translation: 估计与样品核酸模板的测序有关的参数的方法包括：接收与一系列核苷酸产生的核苷酸掺入事件相关的信号数据，其包含（i）包含样品核酸的第一阱 模板和（ii）多个其他含样品的孔; 使用来自第一孔的信号数据确定样品核酸模板的序列信息; 以及构建至少部分地对所述序列信息贡献的一组核苷酸流的相态模型，其中所述模型包括使用来自所述多个其它含样品孔的信号数据确定的信号校正参数。

    METHODS AND COMPUTER PROGRAM PRODUCTS FOR COMPRESSION OF SEQUENCING DATA
    4.
    发明申请
    METHODS AND COMPUTER PROGRAM PRODUCTS FOR COMPRESSION OF SEQUENCING DATA 有权
    用于压缩数据的方法和计算机程序产品

    公开(公告)号：US20130231870A1

    公开(公告)日：2013-09-05

    申请号：US13754566

    申请日：2013-01-30

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Charles SUGNET ,  Simon CAWLEY ,  Mohit GUPTA ,  Iztok MARJANOVIC ,  Todd REARICK ,  Mark BEAUCHEMIN ,  Earl HUBBELL

    IPC: H03M7/30

    CPC classification number: H03M7/30 ,  G06F19/24

    Abstract: A compression method includes measuring a waveform associated with a chemical event occurring on a sensor array, wherein the waveform comprises at least one region associated with expected measured values and at least one region associated with unpredictable measured values; applying a first compression process to the waveform, the first compression process including an averaging of one or more frames in one or more portions of the waveform; and applying a second compression process to the waveform, the second compression process including a truncating of data corresponding to a portion of the waveform that is not related to a nucleotide incorporation component of the waveform.

    Abstract translation: 压缩方法包括测量与传感器阵列上发生的化学事件相关联的波形，其中所述波形包括与预期测量值相关联的至少一个区域和与不可预测的测量值相关联的至少一个区域; 对所述波形应用第一压缩处理，所述第一压缩处理包括所述波形的一个或多个部分中的一个或多个帧的平均值; 以及对所述波形应用第二压缩处理，所述第二压缩处理包括对应于与所述波形的核苷酸掺入成分无关的所述波形的一部分的数据的截断。

    METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR MAKING BASE CALLS IN NUCLEIC ACID SEQUENCING
    6.
    发明申请
    METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR MAKING BASE CALLS IN NUCLEIC ACID SEQUENCING 审中-公开
    方法，系统和计算机可读介质，用于在核酸序列中进行基准测量

    公开(公告)号：US20130090860A1

    公开(公告)日：2013-04-11

    申请号：US13645058

    申请日：2012-10-04

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Marcin SIKORA ,  Earl HUBBELL ,  Simon CAWLEY ,  Christian KOLLER

    IPC: G06F19/20

    CPC classification number: G16B25/00 ,  G01N27/27 ,  G01N27/4145 ,  G16B30/00

    Abstract: A method for nucleic acid sequencing includes: receiving a signal comprising measurements of a parameter measured in response to a plurality of nucleotide flows flowed in a space comprising a sample nucleic acid; normalizing the signal to obtain a normalized signal; adaptively normalizing the normalized signal to obtain an adaptively normalized signal; and predicting a sequence of base calls corresponding to the sample nucleic acid using the adaptively normalized signal.

    Abstract translation: 用于核酸测序的方法包括：接收包含响应于在包含样品核酸的空间中流动的多个核苷酸流测量的参数的测量值的信号; 对信号进行归一化以获得归一化信号; 自适应地归一化归一化信号以获得自适应归一化信号; 以及使用自适应归一化信号来预测对应于样本核酸的碱基呼叫序列。

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