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    SYSTEM FOR REDUCING NOISE IN A CHEMICAL SENSOR ARRAY
    4.
    发明申请
    SYSTEM FOR REDUCING NOISE IN A CHEMICAL SENSOR ARRAY 有权

    公开(公告)号：US20160173080A1

    公开(公告)日：2016-06-16

    申请号：US15049462

    申请日：2016-02-22

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Jeremy JORDAN ,  Todd REARICK

    IPC: H03K17/16 ,  G01N27/414 ,  H03K19/003

    CPC classification number: H03K17/162 ,  G01N27/4145 ,  G06F1/06 ,  G06F1/26 ,  H03K19/00346

    Abstract: A system including a power supply and a clock circuitry to generate a plurality of clock signals. Each clock signal is synchronous with a primary clock signal. First, second, and third clock signals of the plurality of clock signals are asynchronous to each other. The system further includes a plurality of switches. Each switch of the plurality of switches is communicatively coupled to the power supply and the clock circuitry. A first switch of the plurality of switches receives the first clock signal, a second switch of the plurality of switches receives the second clock signal, and a third switch of the plurality of switches receives the third clock signal.

    CAPACITIVE CHARGE PUMP
    5.
    发明申请
    CAPACITIVE CHARGE PUMP 审中-公开
    电容充电泵

    公开(公告)号：US20140361781A1

    公开(公告)日：2014-12-11

    申请号：US14465251

    申请日：2014-08-21

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Peter M. LEVINE ,  Mark James MILGREW ,  Todd REARICK

    IPC: G01N27/414

    Abstract: One or more charge pumps may be used to amplify the output voltage from a chemically-sensitive pixel that comprises one or more transistors. A charge pump may include a number of track stage switches, a number of boost phase switches and a number of capacitors. The capacitors are in parallel during the track phase and in series during the boost phase, and the total capacitance is divided during the boost phase while the total charge remains fixed. Consequently, the output voltage is pushed up.

    Abstract translation: 可以使用一个或多个电荷泵来放大来自包含一个或多个晶体管的化学敏感像素的输出电压。 电荷泵可以包括多个轨道平台开关，多个升压相位开关和多个电容器。 电容器在磁道相位期间并联并且在升压阶段期间串联，并且总电容在升压阶段被分压，而总电荷保持固定。 因此，输出电压被上推。

    SYSTEM FOR REDUCING NOISE IN A CHEMICAL SENSOR ARRAY
    6.
    发明申请
    SYSTEM FOR REDUCING NOISE IN A CHEMICAL SENSOR ARRAY 有权
    化学传感器阵列减少噪声的系统

    公开(公告)号：US20130321044A1

    公开(公告)日：2013-12-05

    申请号：US13801709

    申请日：2013-03-13

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Jeremy JORDAN ,  Todd REARICK

    IPC: H03K17/16

    CPC classification number: H03K17/162 ,  G01N27/4145 ,  G06F1/06 ,  G06F1/26 ,  H03K19/00346

    Abstract: A system including a power supply and a clock circuitry to generate a plurality of clock signals. Each clock signal is synchronous with a primary clock signal. First, second, and third clock signals of the plurality of clock signals are asynchronous to each other. The system further includes a plurality of switches. Each switch of the plurality of switches is communicatively coupled to the power supply and the clock circuitry. A first switch of the plurality of switches receives the first clock signal, a second switch of the plurality of switches receives the second clock signal, and a third switch of the plurality of switches receives the third clock signal.

    Abstract translation: 一种包括电源和时钟电路以产生多个时钟信号的系统。 每个时钟信号与主时钟信号同步。 多个时钟信号的第一，第二和第三时钟信号彼此异步。 该系统还包括多个开关。 多个开关中的每个开关通信地耦合到电源和时钟电路。 多个开关的第一开关接收第一时钟信号，多个开关中的第二开关接收第二时钟信号，并且多个开关中的第三开关接收第三时钟信号。

    APPARATUS AND METHODS FOR PERFORMING ELECTROCHEMICAL REACTIONS
    7.
    发明申请
    APPARATUS AND METHODS FOR PERFORMING ELECTROCHEMICAL REACTIONS 有权

    公开(公告)号：US20230101252A1

    公开(公告)日：2023-03-30

    申请号：US18077404

    申请日：2022-12-08

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： John NOBILE ,  George Thomas ROTH ,  Todd REARICK ,  Jonathan SCHULTZ ,  Jonathan M. ROTHBERG ,  David MARRAN

    IPC: G01N27/30 ,  B01L3/00 ,  G01N27/414

    Abstract: An apparatus includes a reaction vessels coupled to an electronic sensor for monitoring a reaction product in the reaction vessel; a fluidics system for sequentially delivering a plurality of reagents to the reaction vessel, the fluidics system including a plurality of reagent reservoirs in fluidic communication via a plurality of flow paths with a fluidics circuit and to a common passage in fluidic communication between the fluidics circuit and the reaction vessel, a solution reservoir in fluidic communication with the common passage via a branch passage connected with the common passage at a junction between the fluidics circuit and the reaction vessel; and an electrode in contact with a solution within the branch passage, the electrode being in electrical communication with the reaction vessel through fluid extending from the branch passage and through the common passage, the electronic sensor generating an output signal depending on a voltage of the electrode.

    METHODS AND APPARATUS FOR MEASURING ANALYTES
    8.
    发明申请
    METHODS AND APPARATUS FOR MEASURING ANALYTES 有权

    公开(公告)号：US20210116414A1

    公开(公告)日：2021-04-22

    申请号：US17063621

    申请日：2020-10-05

    Applicant: Life Technologies Corporation

    Inventor： Todd REARICK ,  Melville DAVEY ,  Mark BEAUCHEMIN

    IPC: G01N27/416 ,  G16B30/00 ,  G01N27/414

    Abstract: A method, computer program product, and system are provided to calibrate a sensor array with a plurality of sensors. The method can include sweeping a voltage of a reference electrode from a first voltage to a second voltage, where the reference electrode is in fluid communication with the sensor array. The output voltage of each of the plurality of sensors can be monitored at one or more voltages within the first and second voltages. An overall average gain of the plurality of sensors can be calculated at each of the one or more voltages. Further, an acquisition window for the sensor array can be determined. The acquisition window can include a maximum distribution of sensors that provides a maximal overall average gain at a particular reference electrode voltage.

    INTEGRATED SENSOR ARRAYS FOR BIOLOGICAL AND CHEMICAL ANALYSIS
    10.
    发明申请
    INTEGRATED SENSOR ARRAYS FOR BIOLOGICAL AND CHEMICAL ANALYSIS 审中-公开

    公开(公告)号：US20160168635A1

    公开(公告)日：2016-06-16

    申请号：US15051084

    申请日：2016-02-23

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Jonathan M. ROTHBERG ,  James BUSTILLO ,  Mark James MILGREW ,  Jonathan SCHULTZ ,  David MARRAN ,  Todd REARICK ,  Kim L. JOHNSON

    IPC: C12Q1/68 ,  G01N27/414

    CPC classification number: G01N27/4145 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/4148 ,  H01L21/82 ,  C12Q2565/607

    Abstract: The invention is directed to apparatus and chips comprising a large scale chemical field effect transistor arrays that include an array of sample-retaining regions capable of retaining a chemical or biological sample from a sample fluid for analysis. In one aspect such transistor arrays have a pitch of 10 μm or less and each sample-retaining region is positioned on at least one chemical field effect transistor which is configured to generate at least one output signal related to a characteristic of a chemical or biological sample in such sample-retaining region. In one embodiment, the characteristic of said chemical or biological sample is a concentration of a charged species and wherein each of said chemical field effect transistors is an ion-sensitive field effect transistor having a floating gate with a dielectric layer on a surface thereof, the dielectric layer contacting said sample fluid and being capable of accumulating charge in proportion to a concentration of the charged species in said sample fluid. In one embodiment such charged species is a hydrogen ion such that the sensors measure changes in pH of the sample fluid in or adjacent to the sample-retaining region thereof. Apparatus and chips of the invention may be adapted for large scale pH-based DNA sequencing and other bioscience and biomedical applications.

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