公开(公告)号：US10066200B2

公开(公告)日：2018-09-04

申请号：US15198237

申请日：2016-06-30

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Richard Fike ,  Shawn Barrett ,  Zhou Jiang ,  David Judd

IPC: C12N5/00 ,  B29C67/24 ,  B29L9/00 ,  B01J13/06 ,  B01J13/22

Abstract: Compositions and methods are described for preparing media, feeds, and supplements. Such methods and medias may display increased stability of labile components and may use, for example, microsuspension and/or encapsulation technologies, chelation, and optionally, coating and/or mixing the labile compounds with anti-oxidants. The compositions may withstand thermal and/or irradiation treatment and have reduced virus number. These techniques may result in product with extended shelf-life, extended release of their internal components into culture, or in product that can be added aseptically into a bioreactor using minimal volumes. The compositions and methods may optimize the bioproduction workflow and increase efficiency.

公开(公告)号：US09410118B2

公开(公告)日：2016-08-09

申请号：US14367413

申请日：2012-12-21

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Richard Fike ,  Shawn Barrett ,  Zhou Jiang ,  David Judd

IPC: B29C67/24 ,  B29L9/00 ,  C12N5/00

CPC classification number: C12N5/005 ,  B01J13/06 ,  B01J13/22 ,  B29C67/24 ,  B29L2009/00 ,  C12N5/0018 ,  C12N2500/30 ,  C12N2500/38 ,  C12N2511/00 ,  C12N2533/40 ,  C12N2533/74

Abstract: Compositions and methods are described for preparing media, feeds, and supplements. Such methods and medias may display increased stability of labile components and may use, for example, microsuspension and/or encapsulation technologies, chelation, and optionally, coating and/or mixing the labile compounds with anti-oxidants. The compositions may withstand thermal and/or irradiation treatment and have reduced virus number. These techniques may result in product with extended shelf-life, extended release of their internal components into culture, or in product that can be added aseptically into a bioreactor using minimal volumes. The compositions and methods may optimize the bioproduction workflow and increase efficiency.

Abstract translation: 描述了制备培养基，饲料和补品的组合物和方法。 这样的方法和介质可以显示不稳定组分的增加的稳定性，并且可以使用例如微悬浮和/或封装技术，螯合，以及任选地，将不稳定化合物与抗氧化剂包衣和/或混合。 组合物可以承受热和/或照射治疗并且具有减少的病毒数量。 这些技术可能导致产品具有延长的保质期，将其内部组分延长释放到培养物中，或可以无菌地添加到生物反应器中使用最小体积的产品中。 组合物和方法可以优化生物生产工作流程并提高效率。

公开(公告)号：US12203095B2

公开(公告)日：2025-01-21

申请号：US16918838

申请日：2020-07-01

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Richard Fike ,  Shawn Barrett ,  Zhou Jiang ,  David Judd

IPC: C12N5/00 ,  B01J13/06 ,  B01J13/22 ,  B29C67/24 ,  B29L9/00

Abstract: Compositions and methods are described for preparing media, feeds, and supplements. Such methods and medias may display increased stability of labile components and may use, for example, microsuspension and/or encapsulation technologies, chelation, and optionally, coating and/or mixing the labile compounds with anti-oxidants. The compositions may withstand thermal and/or irradiation treatment and have reduced virus number. These techniques may result in product with extended shelf-life, extended release of their internal components into culture, or in product that can be added aseptically into a bioreactor using minimal volumes. The compositions and methods may optimize the bioproduction workflow and increase efficiency.

公开(公告)号：US20150064785A1

公开(公告)日：2015-03-05

申请号：US14367413

申请日：2012-12-21

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Richard Fike ,  Shawn Barrett ,  Zhou Jiang ,  David Judd

IPC: C12N5/00 ,  B29C67/24

CPC classification number: C12N5/005 ,  B01J13/06 ,  B01J13/22 ,  B29C67/24 ,  B29L2009/00 ,  C12N5/0018 ,  C12N2500/30 ,  C12N2500/38 ,  C12N2511/00 ,  C12N2533/40 ,  C12N2533/74

Abstract: Compositions and methods are described for preparing media, feeds, and supplements. Such methods and medias may display increased stability of labile components and may use, for example, microsuspension and/or encapsulation technologies, chelation, and optionally, coating and/or mixing the labile compounds with anti-oxidants. The compositions may withstand thermal and/or irradiation treatment and have reduced virus number. These techniques may result in product with extended shelf-life, extended release of their internal components into culture, or in product that can be added aseptically into a bioreactor using minimal volumes. The compositions and methods may optimize the bioproduction workflow and increase efficiency.

Abstract translation: 描述了制备培养基，饲料和补品的组合物和方法。 这样的方法和介质可以显示不稳定组分的增加的稳定性，并且可以使用例如微悬浮和/或封装技术，螯合，以及任选地，将不稳定化合物与抗氧化剂包衣和/或混合。 组合物可以承受热和/或照射治疗并且具有减少的病毒数量。 这些技术可能导致产品具有延长的保质期，将其内部组分延长释放到培养物中，或可以无菌地添加到生物反应器中使用最小体积的产品中。 组合物和方法可以优化生物生产工作流程并提高效率。