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    TRANSDERMAL THERAPEUTIC SYSTEM WITH HIGH RATE OF UTILIZATION OF ACTIVE SUBSTANCE AND DOSING ACCURACY
    2.
    发明申请
    TRANSDERMAL THERAPEUTIC SYSTEM WITH HIGH RATE OF UTILIZATION OF ACTIVE SUBSTANCE AND DOSING ACCURACY 审中-公开
    具有高活性物质利用率和剂量精确度的超导治疗系统

    公开(公告)号：US20160324799A1

    公开(公告)日：2016-11-10

    申请号：US15216446

    申请日：2016-07-21

    Applicant: LTS Lohmann Therapie-Systeme AG

    Inventor： Michael HORSTMANN ,  Walter Mueller

    IPC: A61K9/70 ,  A61F13/02 ,  A61K31/4468

    CPC classification number: A61K9/7061 ,  A61F13/02 ,  A61F13/0233 ,  A61F13/0246 ,  A61K9/7053 ,  A61K9/7084 ,  A61K31/4468 ,  A61L15/44 ,  A61L2300/402

    Abstract: A transdermal therapeutic system for administering at least one active pharmaceutical ingredient, including a polymer-based layer which is remote from the skin with a rate of application of at least 80 g/m2, and an adhesive skin-contact layer which is adjacent to the polymer-based layer remote from the skin and is based on acrylate copolymers with a rate of application of not more than 50 g/m2. The at least one active pharmaceutical ingredient is present in both the polymer-based layer remote from the skin and the skin-contact layer.

    Abstract translation: 一种透皮治疗系统，其用于施用至少一种活性药物成分，包括以至少80g / m 2的施用速率远离皮肤的聚合物基层和与所述皮肤接触层相邻的粘合剂皮肤接触层 聚合物层远离皮肤，并且基于丙烯酸酯共聚物，其施用速率不超过50g / m 2。 至少一种活性药物成分存在于远离皮肤的聚合物基层和皮肤接触层中。

    Transdermal therapeutic system with high rate of utilization of active substance and dosing accuracy
    4.
    发明授权
    Transdermal therapeutic system with high rate of utilization of active substance and dosing accuracy 有权
    具有高活性物质利用率和给药精度的透皮治疗系统

    公开(公告)号：US09421174B2

    公开(公告)日：2016-08-23

    申请号：US14709126

    申请日：2015-05-11

    Applicant: LTS Lohmann Therapie-Systeme AG

    Inventor： Michael Horstmann ,  Walter Mueller

    IPC: A61K9/70 ,  A61F13/02 ,  A61L15/44

    CPC classification number: A61K9/7061 ,  A61F13/02 ,  A61F13/0233 ,  A61F13/0246 ,  A61K9/7053 ,  A61K9/7084 ,  A61K31/4468 ,  A61L15/44 ,  A61L2300/402

    Abstract: A transdermal therapeutic system for administering at least one active pharmaceutical ingredient, including a polymer layer which is remote from the skin and is based on polyisobutylenes with a rate of application of at least 80 g/m2, and an adhesive skin-contact layer which is adjacent to the polymer layer remote from the skin and is based on acrylate copolymers with a rate of application of not more than 50 g/m2. The at least one active pharmaceutical ingredient is present in both the layer remote from the skin and the skin-contact layer.

    Abstract translation: 一种透皮治疗系统，其用于施用至少一种活性药物成分，所述活性药物成分包括远离皮肤并基于聚异丁烯的施用率至少为80g / m 2的聚合物层和粘合剂皮肤接触层 邻近远离皮肤的聚合物层，并且基于丙烯酸酯共聚物，其施用速率不超过50g / m 2。 所述至少一种活性药物成分存在于远离皮肤的层和皮肤接触层中。

    Method for preventing the crystallization of pharmaceuticals in a polymer film
    5.
    发明授权
    Method for preventing the crystallization of pharmaceuticals in a polymer film 有权
    防止聚合物膜中药物结晶的方法

    公开(公告)号：US09408809B2

    公开(公告)日：2016-08-09

    申请号：US14056025

    申请日：2013-10-17

    Applicant: LTS Lohmann Therapie-Systeme AG

    Inventor： Johannes Josef Leonhard ,  Walter Mueller

    IPC: A61F13/00 ,  A61K9/70 ,  A61K31/381 ,  A61K9/00

    CPC classification number: A61K9/7007 ,  A61K9/006 ,  A61K9/7023 ,  A61K31/381

    Abstract: The invention relates to a method for preventing the crystallization of a pharmaceutical in a polymer film, wherein the solvent-containing coating compound, which comprises a matrix-forming polymer or polymer mixture and at least one pharmaceutical and is spread to produce the polymer film, is temporarily dried at temperatures that is at least 10° C. above the melting temperature of the pharmaceutical contained in the coating compound. The maximum temperature is thus higher than that which is required for mere drying and obviates the need for an additional, time-consuming and expensive work step.

    Abstract translation: 本发明涉及一种用于防止聚合物膜中的药物结晶的方法，其中包含基质形成聚合物或聚合物混合物和至少一种药物并且被扩散以产生聚合物膜的含溶剂的涂料化合物， 在比涂覆化合物中所含药物的熔融温度高至少10℃的温度下暂时干燥。 因此，最高温度高于仅仅干燥所需的温度，并且不需要额外的耗时且昂贵的工作步骤。

    TRANSDERMAL THERAPEUTIC SYSTEM WITH HIGH RATE OF UTILIZATION OF ACTIVE SUBSTANCE AND DOSING ACCURACY
    7.
    发明申请
    TRANSDERMAL THERAPEUTIC SYSTEM WITH HIGH RATE OF UTILIZATION OF ACTIVE SUBSTANCE AND DOSING ACCURACY 审中-公开
    具有高活性物质利用率和剂量精确度的超导治疗系统

    公开(公告)号：US20150238437A1

    公开(公告)日：2015-08-27

    申请号：US14709126

    申请日：2015-05-11

    Applicant: LTS Lohmann Therapie-Systeme AG

    Inventor： Michael HORSTMANN ,  Walter Mueller

    IPC: A61K9/70

    CPC classification number: A61K9/7061 ,  A61F13/02 ,  A61F13/0233 ,  A61F13/0246 ,  A61K9/7053 ,  A61K9/7084 ,  A61K31/4468 ,  A61L15/44 ,  A61L2300/402

    Abstract: A transdermal therapeutic system for administering at least one active pharmaceutical ingredient, including a polymer layer which is remote from the skin and is based on polyisobutylenes with a rate of application of at least 80 g/m2, and an adhesive skin-contact layer which is adjacent to the polymer layer remote from the skin and is based on acrylate copolymers with a rate of application of not more than 50 g/m2. The at least one active pharmaceutical ingredient is present in both the layer remote from the skin and the skin-contact layer.

    Abstract translation: 一种透皮治疗系统，其用于施用至少一种活性药物成分，所述活性药物成分包括远离皮肤并基于聚异丁烯的施用率至少为80g / m 2的聚合物层和粘合剂皮肤接触层 邻近远离皮肤的聚合物层，并且基于丙烯酸酯共聚物，其施用速率不超过50g / m 2。 所述至少一种活性药物成分存在于远离皮肤的层和皮肤接触层中。

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