公开(公告)号：US20190192506A1

公开(公告)日：2019-06-27

申请号：US16288911

申请日：2019-02-28

Applicant: LTS LOHMANN THERAPIE-SYSTEME AG

Inventor： Thomas Hille ,  Michael Horstmann ,  Walter Mueller

IPC: A61K31/485 ,  A61K9/70 ,  A61M37/00 ,  A61K47/12

CPC classification number: A61K31/485 ,  A61K9/7053 ,  A61K9/7069 ,  A61K9/7084 ,  A61K9/7092 ,  A61K47/12 ,  A61M37/00

Abstract: The invention relates to a transdermal therapeutic system for administering the active substance buprenorphine. Said system comprises at least one carboxylic acid that determines the solubility of buprenorphine in the matrix layer and that can likewise be absorbed. The transdermal therapeutic system according to the invention is used in the treatment of pain and characterized by a considerably increased utilization of the active substance.

公开(公告)号：US20130062244A1

公开(公告)日：2013-03-14

申请号：US13652057

申请日：2012-10-15

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Karin Ludwig ,  Michael Horstmann

IPC: B65D83/04 ,  B65B1/04

CPC classification number: B65D75/5855 ,  B65D75/30 ,  B65D75/5805 ,  B65D2215/04

Abstract: A non-reclosable package for products which are prejudicial to health, such as pharmaceutical products. The package comprises a first packaging material element and a second packaging material element. The two packaging material elements are arranged on top of each other. The package has at least one first surface section, at the margin or margins of which the two packaging material elements are releasably connected with each other. At least one cavity, which is enclosed on all sides and receives the product to be packaged, is formed between the two packaging material elements. The package has at least one second surface section lying outside or adjoining the first surface section, and at the margin or margins of which the two packaging material elements are releasably connected with each other. At least one of the two packaging material elements has at least one structure extending within the second surface section and enables the packaging material element(s) to be torn.

Abstract translation: 对健康有害的产品，如药品，不可重新包装的产品。 该包装包括第一包装材料元件和第二包装材料元件。 两个包装材料元件彼此顶部布置。 该包装具有至少一个第一表面部分，在其边缘或边缘处，两个包装材料元件彼此可释放地连接。 在两个包装材料元件之间形成有至少一个封闭在所有侧面并接收待包装的产品的空腔。 所述包装具有位于所述第一表面部分的外部或邻接的至少一个第二表面部分，并且在所述包装材料元件的边缘或边缘处，所述两个包装材料元件彼此可释放地连接。 两个包装材料元件中的至少一个具有在第二表面部分内延伸的至少一个结构，并使包装材料元件被撕裂。

公开(公告)号：US09421174B2

公开(公告)日：2016-08-23

申请号：US14709126

申请日：2015-05-11

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Michael Horstmann ,  Walter Mueller

IPC: A61K9/70 ,  A61F13/02 ,  A61L15/44

CPC classification number: A61K9/7061 ,  A61F13/02 ,  A61F13/0233 ,  A61F13/0246 ,  A61K9/7053 ,  A61K9/7084 ,  A61K31/4468 ,  A61L15/44 ,  A61L2300/402

Abstract: A transdermal therapeutic system for administering at least one active pharmaceutical ingredient, including a polymer layer which is remote from the skin and is based on polyisobutylenes with a rate of application of at least 80 g/m2, and an adhesive skin-contact layer which is adjacent to the polymer layer remote from the skin and is based on acrylate copolymers with a rate of application of not more than 50 g/m2. The at least one active pharmaceutical ingredient is present in both the layer remote from the skin and the skin-contact layer.

Abstract translation: 一种透皮治疗系统，其用于施用至少一种活性药物成分，所述活性药物成分包括远离皮肤并基于聚异丁烯的施用率至少为80g / m 2的聚合物层和粘合剂皮肤接触层 邻近远离皮肤的聚合物层，并且基于丙烯酸酯共聚物，其施用速率不超过50g / m 2。 所述至少一种活性药物成分存在于远离皮肤的层和皮肤接触层中。

公开(公告)号：US08534461B2

公开(公告)日：2013-09-17

申请号：US13652057

申请日：2012-10-15

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Karin Ludwig ,  Michael Horstmann

IPC: B65D83/04

CPC classification number: B65D75/5855 ,  B65D75/30 ,  B65D75/5805 ,  B65D2215/04

Abstract: A non-reclosable package for products which are prejudicial to health, such as pharmaceutical products. The package comprises a first packaging material element and a second packaging material element. The two packaging material elements are arranged on top of each other. The package has at least one first surface section, at the margin or margins of which the two packaging material elements are releasably connected with each other. At least one cavity, which is enclosed on all sides and receives the product to be packaged, is formed between the two packaging material elements. The package has at least one second surface section lying outside or adjoining the first surface section, and at the margin or margins of which the two packaging material elements are releasably connected with each other. At least one of the two packaging material elements has at least one structure extending within the second surface section and enables the packaging material element(s) to be torn.

Abstract translation: 对健康有害的产品，如药品，不可重新包装的产品。 该包装包括第一包装材料元件和第二包装材料元件。 两个包装材料元件彼此顶部布置。 该包装具有至少一个第一表面部分，在其边缘或边缘处，两个包装材料元件彼此可释放地连接。 在两个包装材料元件之间形成有至少一个封闭在所有侧面并接收待包装的产品的空腔。 所述包装具有位于所述第一表面部分的外部或邻接的至少一个第二表面部分，并且在所述包装材料元件的边缘或边缘处，所述两个包装材料元件彼此可释放地连接。 两个包装材料元件中的至少一个具有在第二表面部分内延伸的至少一个结构，并使包装材料元件被撕裂。

公开(公告)号：US11291745B2

公开(公告)日：2022-04-05

申请号：US16239862

申请日：2019-01-04

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Michael Horstmann ,  Christian Hausen ,  Patrick Mohr ,  Karin Ludwig ,  Tobias Kleudgen

IPC: A61L15/44 ,  A61L15/24 ,  A61L15/58

Abstract: Adhesive bandages are provided with a water-vapor permeable back layer and an adhesive layer, in which the adhesive layer includes 10 weight percent of a disperse internal phase of hydrophilic particles that are water-swellable in an outer phase that includes at least 10 weight percent of a styrene block copolymer and at least 20 weight percent of an ester resin of colophony, and that can further contain at least one anti-virus substance.

公开(公告)号：US10881607B2

公开(公告)日：2021-01-05

申请号：US16715972

申请日：2019-12-16

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Christoph Schmitz ,  Mohammad Sameti ,  Andreas Koch ,  Michael Horstmann

IPC: A61K9/00 ,  A61K9/70 ,  A61K47/32 ,  A61K47/12 ,  A61K31/00

Abstract: The invention relates to a composition for transdermal delivery, particularly iontophoretic transdermal delivery, of at least one cationic active agent or a salt thereof. The composition includes at least one cationic active agent or a salt thereof, at least one polyamine or/and polyamine salt, water or an aqueous solvent mixture, and optionally one or more additives. The invention further relates to the use of such composition as a component of a transdermal patch or of an iontophoretic transdermal patch, as well as to the use of such composition in a method for transdermally and/or iontophoretically administering cationic active agents. The invention further includes methods for determining the in vitro skin permeation properties of an active-agent-containing iontophoretic composition.

公开(公告)号：US10471021B2

公开(公告)日：2019-11-12

申请号：US15867050

申请日：2018-01-10

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Michael Horstmann ,  Gerd Hoffmann ,  Sandra Wiedersberg

IPC: A61K9/70 ,  A61K38/24 ,  A61K38/27 ,  A61P5/06

Abstract: The invention relates to a transdermal therapeutic system (TTS), which is suited for the administration of a peptide to a patient through skin treated with ablation. The transdermal therapeutic system includes a back layer and an active substance-containing layer that contains at least one peptide and a carrier substance, preferably as a textile web material.

公开(公告)号：US09717698B2

公开(公告)日：2017-08-01

申请号：US15216446

申请日：2016-07-21

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Michael Horstmann ,  Walter Mueller

IPC: A61K9/70 ,  A61F13/02 ,  A61L15/44 ,  A61K31/4468

CPC classification number: A61K9/7061 ,  A61F13/02 ,  A61F13/0233 ,  A61F13/0246 ,  A61K9/7053 ,  A61K9/7084 ,  A61K31/4468 ,  A61L15/44 ,  A61L2300/402

Abstract: A transdermal therapeutic system for administering at least one active pharmaceutical ingredient, including a polymer-based layer which is remote from the skin with a rate of application of at least 80 g/m2, and an adhesive skin-contact layer which is adjacent to the polymer-based layer remote from the skin and is based on acrylate copolymers with a rate of application of not more than 50 g/m2. The at least one active pharmaceutical ingredient is present in both the polymer-based layer remote from the skin and the skin-contact layer.

公开(公告)号：US10596126B2

公开(公告)日：2020-03-24

申请号：US16380069

申请日：2019-04-10

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Michael Horstmann ,  Mohammad Sameti ,  Tobias Jung

IPC: A61K9/70

Abstract: The present invention relates to a transdermal therapeutic system, preferably a transdermal patch, having an active ingredient-containing matrix formed substantially of a water-insoluble base material, such as rubber and synthetic polymers, into which is incorporated water-soluble and/or water-swellable inclusion bodies, e.g. inclusion bodies formed from polyvinyl alcohol or polyethylene glycol, that further include micronized or nanoscale active ingredient particles.

公开(公告)号：US10315020B2

公开(公告)日：2019-06-11

申请号：US14998302

申请日：2015-12-24

Applicant: LTS LOHMANN THERAPIE-SYSTEME AG

Inventor： Uwe Wortmann ,  Roman Hadaschik ,  Michael Horstmann

IPC: A61M37/00 ,  A61K9/00 ,  A61F13/02

Abstract: A device with a positioning frame which can be adhered onto the skin and with a transdermal therapeutic system which can be inserted into a cut-out that passes through the positioning frame. The active substance dispensing outlet side of the inserted transdermal therapeutic system facing the skin. The device includes a tool unit which can be inserted into the cut-out of the positioning frame and centered in said cut-out in order to produce openings at least in the uppermost layer of the skin.